| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Polyamines as Antiparasitics |
| Discussion Leader: Pinar Obakan (Istanbul Kultur University, Turkey) |
| 3:45 pm - 4:15 pm | Nigel Yarlett (Pace University, USA)
"Polyamine Metabolism in Cryptosporidium parvum" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Polyamines, Parasites and Human Health |
| Discussion Leader: Nigel Yarlett (Pace University, USA) |
| 7:30 pm - 7:50 pm | Bianca Verlinden (University of Pretoria, South Africa)
"Polyamine Analogues as Next-Generation Antimitotic Scaffolds that Selectively Targets Intraerythrocytic Plasmodium falciparum" |
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:10 pm | Oleg Volkov (The University of Texas Southwestern Medical Center, USA)
"Discovery and Validation of Drug-Like Inhibitors of Trypanosoma brucei S-Adenosyl-L-Methionine Decarboxylase" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:35 pm | Akihiko Sakamoto (Chiba Institute of Science, Japan)
"Effects of a CR Sequence in mRNA and Polyamines on Protein Synthesis" |
| 8:35 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | Helen Lightfoot (ETH Zürich, Switzerland)
"Interplay Between Polyamines and Quadruplexes in the Polyamine Synthesis Pathway" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Craig Kutz (Medical University of South Carolina, USA)
"Preclinical Testing of LSD1/KDM1A and SMOx Inhibitor as Novel Drug Candidates to Prevent Cardiac Ischemia-Reperfusion Injury" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Polyamines in Cancer and Human Diseases |
| Discussion Leaders: Steven Holshouser (Medical University of South Carolina, USA) and Enzo Agostinelli (Sapienza University of Rome, Italy) |
| 9:00 am - 9:15 am | Enzo Agostinelli (Sapienza University of Rome, Italy)
"Can Polyamines Be Used to Combat Cancer?" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Ajda Coker (Istanbul Kultur University, Turkey)
"Curcumin Induced Apoptotic Cell Death by Modulating ODC and SSAT Expression via NF-κB and PAPR-γ in GH Overexpressed MCF-7 and MDA-MB231 Breast Cancer Cells" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Alexander Ivanov (Engelhardt Institute of Molecular Biology, Russia)
"N1,N11-Diethylnorspermine Induces Epithelial-to-Mesenchymal Transition of Differentiated Human Hepatic HepaRG Cells" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Vaibhav Jain (CSIR-Institute of Genomics and Integrative Biology, India)
"The Role of Spermine Oxidase in Asthma" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Jenaro Garcia-Huidobro Prieto (University of Arizona Cancer Center, USA)
"Identification of a New Genetic Variability and Molecular Mechanism in the ODC1 Gene Which Convey a Polyamine Addiction Phenotype in Colorectal Adenomas and Neuroblastoma" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Shima Nakanishi (Moffitt Cancer Center, USA)
"Role of the Polyamine-Hypusine Circuit in Myc-Driven Tumorigenesis" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Polyamines in Cell Metabolism |
| Discussion Leader: Anthony Michael (The University of Texas Southwestern Medical Center, USA) |
| 1:30 pm - 1:45 pm | Hayley Affronti (Roswell Park Cancer Institute, USA)
"Leveraging the Metabolic Stress of Polyamine Biosynthesis in Prostate Cancer Towards a Novel Therapeutic Approach" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Emily Anderson-Baucum (Indiana University School of Medicine, USA)
"Deoxyhypusine Synthase Promotes Macrophage Inflammation and M1 Polarization" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Amy Jancewicz (University of Wisconsin-Madison, USA)
"Characterizing Molecular Mechanisms of Cadaverine Action in Arabidopsis thaliana Environmental Response" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
