Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Polyamine Metabolism - Mechanistic Insights
Discussion Leader: Anthony Pegg (Pennsylvania State University College of Medicine, USA)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
Marie Mooney (Michigan State University, USA)
"Novel Interaction Between Ornithine Decarboxylase and Sepiapterin Reductase"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Manuela Cervelli (Roma Tre University, Italy)
"Molecular Mechanisms Involved in Glutamate Excitotoxicity Linked to Spermine Oxidase"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functions of Cellular Polyamines
Discussion Leader: Myung-Hee Park (National Institute of Dental and Craniofacial Research, NIH, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
Yuri Ishii (Kwansei-Gakuin University, Japan)
"Polyamines in Vinegar Are Key Compounds for Effective Trapping of the Spotted Wing Drosophila "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Vaibhav Jain (CSIR-Institute of Genomics and Integrative Biology, India)
"Polyamine Homeostasis in Asthma"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Tahira Fatima (Purdue University, USA)
"Higher 'Spermidine+Spermine/Putrescine' Ratio in Transgenic Tomato Correlates with Higher Content of Flavonoids Beneficial for Human Health and Defense"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Vladimir Valuev-Elliston (Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russia)
"Role of Polyamine in Endothelial-Mesenchymal Transition (EMT) in Liver Cells"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Iti Mehta (University of Texas at Dallas, USA)
"The Putrescine Requirement for Escherichia coli Swarming Motility"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Polyamines in Therapeutics - As Targets and Agents
Discussion Leader: Otto Phanstiel (University of Central Florida, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Michelle Olsen (National Emerging Infectious Diseases Laboratories, Boston University, USA)
"Polyamines and Hypusinated eIF5A Are Required for Ebolavirus Gene Expression and Replication"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Andrea Flynn (Children's Hospital of Philadelphia, USA)
"Difluoromethylornithine (DFMO) Inhibits Global Protein Translation and Has Anti-Tumor Activity in Neuroblastoma"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
Spencer Rosario (Roswell Park Cancer Institute, USA)
"In Silico Identification of Polyamine Metabolic Dysregulation Across Cancers"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
Nathan Sunada (University of Hawaii at Hilo, USA)
"Polyamines Regulate Neuroblastoma Progression Through a Mechanism that Involves TRPM7"
10:30 am - 10:35 am
Discussion
10:35 am - 10:55 am
Steven Holshouser (Medical University of South Carolina, USA)
"Design and Synthesis of Novel, Potent Polyamine Oxidase Family Inhibitors as Efficacious Agents in Pancreatic Cancer"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Keynote Session: Polyamines in Therapeutics
Discussion Leader: Robert Casero (Johns Hopkins University School of Medicine, USA)
1:30 pm - 2:20 pm
Otto Phanstiel (University of Central Florida, USA)
"Polyamines in Therapeutics"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
