Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Polyamines in Cellular Metabolism, Human Health and Disease
Discussion Leader: Stephan Sigrist (Free University of Berlin, Germany)
3:45 pm - 3:50 pm
Opening Remarks
3:50 pm - 4:05 pm
Bruno Ramos-Molina (Institute of Biomedical Research in Malaga (IBIMA), Spain)
"Effect of a Lifestyle Intervention Program with Energy-Restricted Mediterranean Diet and Exercise on the Serum Polyamine Metabolome in Individuals at High Cardiovascular Risk"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Jonathan Reinoso Sanchez (Università Roma Tre, Italy)
"SMOX, p21 and Non-Coding RNAs in the Physiopathology of Skeletal Muscle"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamines in Cellular Metabolism, Human Health and Disease (continued ) / Keynote Session: Implications in Polyamine Research
Discussion Leader: Susan Gilmour (Lankenau Institute for Medical Research, USA)
7:30 pm - 7:45 pm
Vandana Sekhar (University of Central Florida, USA)
"Regulation of the P-Type ATPase ATP13A3 for Polyamine Transport in Pancreatic Cancers"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Aryn Rowsam (Roswell Park Comprehensive Cancer Center, USA)
"Leveraging Polyamine Metabolic Stress to Enhance Sensitivity to Epigenetic Therapy for Prostate Cancer"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Spencer Rosario (Roswell Park Cancer Institute, USA)
"Polyamine Biosynthetic Metabolic Dysregulation: Targeting and the Adaptive Response"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Meghan Travers (Johns Hopkins University School of Medicine, USA)
"DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of an Ovarian Cancer Mouse Model"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:25 pm
Robert Casero (Johns Hopkins University School of Medicine, USA)
"Implications in Polyamine Research: Past, Present and Future"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Plants, Parasites and Other Microorganisms
Discussion Leader: Sigrid Roberts (Pacific University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Jasmine Perdeh (Pacific University, USA)
"Polyamines: Paramount for Parasite Proliferation and Persistence"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
Hiromi Shimokawa (Ishikawa Prefectural University, Japan)
"Genetic and Biochemical Analysis of Carboxyspermidine Decarboxylase of the Prominent Intestinal Microbiota Species Bacteroides thetaiotaomicron "
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Rajtilak Majumdar (Agricultural Research Service, USDA, USA)
"Targeting Polyamine Metabolism for Control of Fungal Pathogenesis and Increasing Host Resistance During the Maize-Aspergillus flavus Interaction"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Yvonne Latour (Vanderbilt University, USA)
"The Macrophage Reverse Transsulfuration Pathway Mediates Helicobacter pylori Immunopathogenesis by Regulating Polyamine Synthesis"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Sergii Krysenko (University of Tübingen, Germany)
"Characterization of the Gamma-Glutamylpolyamine Synthetase GlnA3 in Mycobacterium tuberculosis as a Potential Drug Target"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Polyamines in Therapeutics: Targets and Applications
Discussion Leader: Otto Phanstiel (University of Central Florida, USA)
1:30 pm - 1:45 pm
Aiste Dobrovolskaite (University of Central Florida, USA)
"Development of Compounds Which Inhibit Polyamine Trafficking in Pancreatic Cancer Cells"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Sai Preethi Nakkina (Univeristy of Central Florida, USA)
"Effectiveness of Novel Therapeutics Targeting Polyamine Biosynthesis and Transport in Pancreatic Tumor Progression"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
