Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Cellular functions of polyamines
Discussion Leader: Robert Casero (Johns Hopkins University , United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
Brian Tooker (National Jewish Health, United States)
"Investigating the Relationship Between Free and Bound Polyamines"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Mollie Shinkle (IUPUI, United States)
"Investigating the Role of Deoxyhypusine Synthase in Neurodevelopment"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Polyamines in human health and disease
Discussion Leader: Susan Gilmour (Lankenau Institute for Medical Research, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
Oluwaseun Akinyele (University of Pittsburgh, United States)
"Characterizing the Phenotypic Abnormalities of a Novel Mouse Model of Snyder-Robinson Syndrome for Therapeutic Development"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Joseph Goode (University of Central Florida, United States)
"Polyamine Blockade Therapy: A Strategy to Block Immunosuppression in Pancreatic Cancer"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Sarah van Veen (KU Leuven, Belgium)
"ATP13A4, a Novel Polyamine Transporter Implicated in Breast Cancer"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
Anthony Pegg (Penn State University College of Medicine, United States)
"The Critical Roles of Polyamines in Growth and Development"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Polyamines as Therapeutic Targets and Agents
Discussion Leader: Keith Wilson (Vanderbilt University Medical Center, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Cristian Fiorucci (Roma Tre University, Italy)
"Spermidine Treatment Affects Gene Expression in Mouse Model of Amyotrophic Lateral Sclerosis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
Holly Moots (University of Central Florida, United States)
"LAT-eral Thinking: Targeting Pancreatic Cancer’s Polyamine Dependence Through Methionine Depletion"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Amelia Furbish (Medical University of South Carolina, United States)
"Structure-Based Characterization and Strategic Optimization of a Novel SMOX Inhibitor Drug Scaffold"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Ricardo Cordova (Indiana University School of Medicine, United States)
"The Role of GCN2 in Amino Acid Homeostasis and Polyamines in Prostate Cancer"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Ayush Rana (University of Miami, United States)
"Polyamine Acetylation Drives Immune Remodeling in Glioblastoma Tumors"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Role of Polyamines in Plants, Parasites, and Model Organisms
Discussion Leader: Autar Mattoo (U.S. Department of Agriculture, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 1:50 pm
Brinda Goda Lakshmi Didugu (GITAM (Deemed to be University), India)
"Spermidine Induces Autophagy of the Silk Gland by Triggering the ATG8 Pathway"
1:50 pm - 1:55 pm
Discussion
1:55 pm - 2:10 pm
Arya Vindu (National Institutes of Health, United States)
"Critical Role for Polyamines in Candida albicans Virulence"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
