Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Post-Transcriptional
Processes in Transcription and RNA Stability |
| Discussion Leader: Gideon Dreyfuss (Howard Hughes Medical Institute / Perelman School of Medicine, University of Pennsylvania, USA) |
7:40 pm - 8:15 pm | Phillip Sharp (Massachusetts Institute of Technology, USA) "The Importance of Post-Transcriptional Processes in Transcription and RNA Stability" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Torben Jensen (Aarhus University, Denmark) "Sorting Mammalian RNA for Function or Decay" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Tracy Johnson (University of California, Los Angeles, USA) "Chromatin, Transcription and Splicing" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Single Molecules,
Structures and Mechanisms |
| Discussion Leader: Joan Steitz (Yale University, USA) |
9:00 am - 9:20 am | Alexey Petrov (Stanford University, USA) "Dynamics of Translation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Rebecca Voorhees (MRC Laboratory of Molecular Biology, United Kingdom) "Mechanism of Protein Transport to the Endoplasmic Reticulum" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Jon Lorsch (National Institute of General Medical Sciences, NIH, USA) "mRNA Recruitment to the Eukaryotic Ribosome" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Martin Bushell (University of Leicester, United Kingdom) "The Central Role of RNA Helicases in the Control of Gene Expression by MicroRNAs and the Ccr4-Not Complex" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Kevin Weeks (University of North Carolina at Chapel Hill, USA) "The Pervasive Role of RNA Structure in lncRNA Function" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Joerg Braun (University of Massachusetts Medical School, USA) "Single-Molecule Analysis of Mammalian Spliceosome Assembly" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Marvin Tanenbaum (Hubrecht Institute, The Netherlands) "Dynamics of Translation of Single mRNA Molecules In Vivo" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RNA Localization and
Transport |
| Discussion Leader: Marvin Tanenbaum (Hubrecht Institute, The Netherlands) |
7:30 pm - 7:50 pm | Robert Singer (Albert Einstein College of Medicine, USA) "Following Single mRNA Localization and Translation in Living Neurons" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Eric Lecuyer (Institut de Recherches Cliniques de Montréal (IRCM), Canada) "Studying the Impact of Gene Positioning in the Genome on mRNA Localization in the Cytoplasm" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Stavroula Mili (Center for Cancer Research, National Cancer Institute, NIH, USA) "Cell Contractility Differentially Affects RNA Localization at Cell Protrusions to Promote Cell Migration" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Guiping Wang (Harvard University, USA) "Image-Based Single-Cell Transcriptomics Reveals Intracellular Transcriptome Organization" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Joseph Luna (The Rockefeller University, USA) "Colocalization-CLIP: A High-Throughput Survey of RNA Localization in Mammalian Cells" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Edward Wallace (University of Edinburgh, United Kingdom) "Heat-Triggered RNA-Protein Granules Contain a Large, Specific, Subset of mRNA" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of Translation |
| Discussion Leader: Martin Bushell (University of Leicester, United Kingdom) |
9:00 am - 9:20 am | Susan Ackerman (University of California, San Diego, USA) "Translation Defects and Neurological Dysfunction" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Nicholas Ingolia (University of California, Berkeley, USA) "Global Profiling of Protein Synthesis and Translational Regulation" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Maria Barna (Stanford University, USA) "Specialized Ribosomes: A New Frontier in Gene Regulation, Organismal Development, and Evolution" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Joel Richter (University of Massachusetts Medical School, USA) "Rescuing Fragile X" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Mark Kay (Stanford University School of Medicine, USA) "The Role of a Small Non-Coding tRNA Fragment in Translational Regulation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Nicholas Guydosh (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) "Short Ribosome Footprints Reveal Extensive mRNA Cleavage Upstream of Poly(A) Translation Events" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Sergej Djuranovic (Washington University, USA) "Regulation of Gene Expression by Interplay of Ribosomes and mRNA Surveillance Pathways" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | RNA Modification, Decay and
Silencing |
| Discussion Leader: Lynne Maquat (University of Rochester School of Medicine and Dentistry, USA) |
7:30 pm - 7:50 pm | Brenda Bass (University of Utah, USA) "A Role for RNA Editing in Modulating Gene Silencing During C. elegans Development" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Chuan He (University of Chicago, USA) "RNA Methylation in Gene Expression Regulation" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Jin Billy Li (Stanford School of Medicine, USA) "A-to-I Editing of RNA" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Thomas Carlile (Massachusetts Institute of Technology, USA) "Recognition of mRNA Substrates by a tRNA Modifying Enzyme" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Sandra Wolin (Yale University, USA) "Using Retroviruses to Unveil RNA Surveillance Pathways" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Virus-Host Interactions |
| Discussion Leader: Mark Kay (Stanford University School of Medicine, USA) |
9:00 am - 9:20 am | Sara Cherry (University of Pennsylvania, USA) "Genetic and Mechanistic Studies of Viral-Host Interactions" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Eva Gottwein (Northwestern University, USA) "Targets and Functions of Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Ella Hartenian (University of California, Berkeley, USA) "Investigating an mRNA Degradation-Transcription Feedback Loop During Viral Infection" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Stacy Horner (Duke University Medical Center, USA) "Roles for m6A in Virus Infection" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Sean Whelan (Harvard Medical School, USA) "Synthesis and Translation of Vesicular Stomatitis Virus mRNA" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Demian Cazalla (University of Utah, USA) "A Viral
Sm-Class RNA Base-Pairs with mRNAs and Recruits miRNAs to Inhibit Apoptosis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Michel Tassetto (University of California, San Francisco, USA) "Circulating Immune Cells in Drosophila Mediate the Amplification and Memory of a Systemic Nucleic Acid-Based Antiviral Response" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Processing and Function of Coding and Noncoding
RNAs |
| Discussion Leader: Tracy Johnson (University of California, Los Angeles, USA) |
7:30 pm - 7:50 pm | John Rinn (Harvard University, USA) "Evolution and Function of Local Repeats in the FIRRE Locus" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Jeremy Wilusz (University of Pennsylvania, USA) "Regulation of Circular RNA Expression" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Hiten Madhani (University of California, San Francisco, USA) "The Spliceosome In Vivo" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Peter Sudmant (Massachusetts Institute of Technology, USA) "3' UTR Fragments Accumulate in Aging Neuronal Subtypes of Mice and Humans" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Eric Wang (University of Florida, USA) "Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | RNA in Disease |
| Discussion Leader: Sandra Wolin (Yale University, USA) |
9:00 am - 9:20 am | Maurice Swanson (University of Florida, USA) "Impact of Microsatellite Mutations on Pre-mRNA Processing Regulation and Disease" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | John Carulli (Biogen, USA) "Measuring the Transcriptional Impact of RNA-Targeted Therapies: From Mechanisms to Biomarkers" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Frank Bennett (Ionis Pharmaceuticals, USA) "Antisense Drugs for the Treatment of Inherited Neurological Diseases" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Eliezer Calo (Stanford University School of Medicine, USA) "Mechanistic Insights into Ribosomopathies: Disorders of Ribosome Dysfunction" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Adam Pavlicek (Regulus Therapeutics, USA) "Therapeutic Modulation of MicroRNA Function: Opportunities and Practical Considerations" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Richard Padgett (Cleveland Clinic, USA) "Spliceosomal snRNA Mutations in Human Diseases" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Olga Anczukow (The Jackson Laboratory for Genomic Medicine, USA) "Role of SR Proteins and Splicing Targets in Breast Cancer and Metastasis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Global Analysis of Post-Transcriptional
Gene Regulation |
| Discussion Leader: Brenton Graveley (UConn Health, USA) |
7:30 pm - 7:50 pm | Benjamin Blencowe (University of Toronto, Canada) "Global Analysis of RNA Processing" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Brenton Graveley (UConn Health, USA) "Comprehensive Characterization of the Functional RNA Elements Encoded in the Human Genome" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Marta Mele (Harvard University, USA) "Chromatin Environment, Transcriptional and Post-Transcriptional Regulation Distinguishes LncRNAs and mRNAs" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Jason Underwood (Pacific Biosciences / University of Washington, USA) "Long Read Transcript Sequencing of Complex Genomic Regions" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Nikolaus Rajewsky (Max Delbruck Center for Molecular Medicine, Germany) "Systems Biology of Gene Regulatory Elements" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |