Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Emerging Concepts in RNA Biology
Discussion Leader: Joan Steitz (Yale University , United States)
7:40 pm - 8:00 pm
Christine Mayr (Memorial Sloan Kettering Cancer Center, United States)
"Organization of Cellular Processes by Cytoplasmic Condensates"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Mitch Guttman (California Institute of Technology, United States)
"How LncRNAs Shape Chromatin Structure to Control Gene Expression"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Benjamin Blencowe (University of Toronto, Canada)
"Role of Post-Transcriptional Regulation From Genotype to Phenotype"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Roy Parker (University of Colorado Boulder, United States)
"RNP Granules in Health and Disease"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Role of Post-Transcriptional Regulation From Genotype to Phenotype
Discussion Leader: Brenton Graveley (UConn Health, United States)
9:00 am - 9:20 am
Auinash Kalsotra (University of Illinois at Urbana-Champaign, United States)
"The Good and Bad of RNA Splicing: Choose Your Alternative"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
William Fairbrother (Brown University, United States)
"Splicing Mutations and the Evolution of Exonic Splicing Enhancers"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Xinshu Xiao (University of California, Los Angeles, United States)
"Deciphering the Function of Single-Nucleotide Variants in the RNA"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Angela Brooks (University of California, Santa Cruz, United States)
"Investigating the Functional Role of Recurrent U2AF1 S34F Mutation in Lung Adenocarcinoma"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Sarah Harris (UNC Chapel Hill, United States)
"Evolution of RNA Binding and Regulation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ana Fiszbein (Boston University, United States)
"Evolution and Regulation of Hybrid Exons"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Alain Laederach (University of North Carolina at Chapel Hill, United States)
"In vivo RNA Structure at the Exon-Intron Junction Modulated by Rare Disease Variants, a Key Modulator of Splice Site Selection"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Kristen Lynch (University of Pennsylvania, United States) and Karla Neugebauer (Yale University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
3’ Processing
Discussion Leader: Chris Burge (MIT, United States)
7:30 pm - 7:50 pm
Bin Tian (The Wistar Institute, United States)
"Alternative Polyadenylation, Mechanisms and Consequences"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Eric Wagner (University of Rochester, United States)
"Cellular Regulation of 3’-End Formation Through the Integrator Complex"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sara Cherry (University of Pennsylvania, United States)
"Defining the Interface Between RNA Viruses and Cellular RNA Binding Proteins"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Yongsheng Shi (University of California, Irvine, United States)
"Regulation of mRNA 3’ Processing in Development and Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
RNA Decay
Discussion Leader: Karla Neugebauer (Yale University, United States)
9:00 am - 9:20 am
Sujatha Jagannathan (University of Colorado Anschutz Medical Campus, United States)
"RNA decay; High-Throughput Examination of Rules Governing Nonsense-mediated RNA Decay"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Bobby Hogg (National Institutes of Health, United States)
"Gene Expression Regulation by NMD: Mechanisms of mRNA Protection and Deprotection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:40 am
Madeline McGinnis (University of Texas Southwestern Medical Center, United States)
"Exonuclease Xrn1 has a Prominent Role in Nutrient Sensing and the Regulation of Autophagy"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Jackson Gordon (Yale University, United States)
"Phosphorylation-Dependent Inhibition of PABPN1 Maintains poly(A) Tail Lengths During Mitosis"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Lynne Maquat (University of Rochester Medical Center, United States)
"Nonsense-Mediated mRNA Decay in Health and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Monica Pillon (Baylor College of Medicine, United States)
"Uncovering New Mechanisms of Regulation for Disease-associated Ribonucleases"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Yizhu Lin (University of California, San Francisco, United States)
"Encoding RNA Binding Protein Footprints in RNA Sequence Using an Improved RNA Adenosine Deaminase"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Heidi Cook-Andersen (University of California, San Diego, United States)
"Post-Transcriptional Mechanisms Driving the Transition from Oocyte to Embryo in Mammals"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Structure and Modifications
Discussion Leader: Wendy Gilbert (Yale University, United States)
7:30 pm - 7:50 pm
Richard Gregory (Boston Children's Hospital / Harvard Medical School, United States)
"Role of RNA Methyltransferases in Gene Expression and Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Nicole Martinez (Stanford University, United States)
"Uncovering New Functions of RNA Modifications in mRNA Processing"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Bongmin Bae (Harvard University, United States)
"Direct Mapping of snoRNA Interaction Sites Identified Novel snoRNA Targets in Neurons"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Steve Bonilla (University of Colorado, School of Medicine, United States)
"A Viral RNA Hijacks Cellular Machinery Using Conformational Changes of a Dynamic tRNA-Like Structure"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Blanton Tolbert (CWRU, United States)
"Mutual Allostery: An Underdeveloped Mechanism to Regulate Protein-RNA Biology"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Translation
Discussion Leader: Lynne Maquat (University of Rochester Medical Center, United States)
9:00 am - 9:20 am
Katrin Karbstein (UF Scripps Biomedical Research, United States)
"Ribosome Remodeling and Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Samantha Fernandez (University of California, Berkeley, United States)
"Post-Termination Ribosome Complexes Modulate Alternative Protein Isoform Expression"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Ruoyu Chen (Whitehead Institute, United States)
"Translational Regulation by Drosophila Embryonic Germ Granules"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kathy Fange Liu (The University of Pennsylvania, United States)
"RNA Species Dance to the Beat of Modifications"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Junjie Guo (Yale University, United States)
"Targeting Programmed -1 Ribosomal Frameshifting in SARS-CoV-2"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Michael Lawson (Stanford University School of Medicine, United States)
"Basis of Speed and Fidelity in Eukaryotic Translation Termination"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Gloria Brar (University of California, Berkeley, United States)
"Long Undecoded Transcript Isoforms Underlie Dramatic Changes in Cellular State"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Joel Neilson (Baylor College of Medicine, United States)
"CELF-ish Control of Translation Initiation in Breast Cancer Progression"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
RNA Localization and Assembly
Discussion Leader: Douglas Black (University of California, Los Angeles, United States)
5:30 pm - 5:50 pm
Beatriz Fontoura (University of Texas Southwestern Medical Center, United States)
"RNA Splicing and Trafficking Through Nuclear Speckles"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Robin Stanley (National Institute of Environmental Health Sciences, NIH, United States)
"Regulation of Pre-rRNA Processing"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Rena Ren (Massachusetts Institute of Technology, United States)
"Subcellular RNA Kinetic Landscape Revealed By Spatiotemporally Resolved Transcriptomics"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Megan Norris (UT Southwestern Medical Center, United States)
"mRNA Localization to Protrusions Regulates Migration in Melanoma Cells"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Kimberly Mowry (Brown University, United States)
"RNA-Protein Interactions in RNA Transport Granules"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
RNP Function and Disease Implications
Discussion Leader: Manuel Ares (University of California, Santa Cruz, United States)
9:00 am - 9:20 am
Peter Sarnow (Stanford University, United States)
"Roles for RNA Virus-Derived Circular RNAs in Viral Pathogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Esther Obeng (St. Jude Children's Research Hospital, United States)
"SF3B1 Mutations in Myeloid Malignancies"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Brittany Angarola (The Jackson Laboratory, United States)
"Defining Aging-Associated RNA Splicing as an Oncogenic Factor in Breast"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Timofey Karginov (UConn Health, United States)
"T Cell Activation Induces Splicing of Ultraconserved Poison Exon Elements in RNA Binding Proteins to Allow Expansion and Effector Function During Immune Response"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kathryn Hamilton (University of Pennsylvania / Children's Hospital of Philadelphia, United States)
"Dynamic Regulation of Intestinal Tissue Repair via RNA Binding Protein IMP1/IGF2BP1"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Adrian Krainer (Cold Spring Harbor Laboratory, United States)
"Antisense-Mediated PKM Splice-Switching to Target Hepatocellular Carcinoma"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Eric Wang (University of Florida, United States)
"Repeat Expansions Instigate Supply Chain Issues in the Nucleus and Cytoplasm"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Integration of RNA Biogenesis Steps
Discussion Leader: Nicholas Conrad (University of Texas Southwestern Medical Center, United States)
7:30 pm - 7:50 pm
Matthew Simon (Yale University, United States)
"Revealing the Dynamic Regulation of Cellular RNAs Using Nucleotide Recoding Experiments"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Rui Zhao (University of Colorado Anschutz Medical Campus, United States)
"What Do We Learn About Alternative Splicing From Yeast U1 snRNP?"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Tracy Johnson (University of California, Los Angeles, United States)
"RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene Expression"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
David Bentley (University of Colorado School of Medicine, United States)
"Transcription Speed: Why it Matters and How to Control it"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure