Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Coupling of Transcription and Splicing
Discussion Leader: Maria Alexis (Massachusetts Institute of Technology, USA)
3:45 pm - 3:55 pm
Heather Drexler (Harvard University, USA)
"Exploring the Nascent Transcriptome with Direct RNA Nanopore Sequencing"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Ana Fiszbein (Massachusetts Institute of Technology, USA)
"Splicing-Dependent Regulation of Transcription Start Sites"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Alyssa Casill (Albert Einstein College of Medicine, USA)
"Genome-Wide Determination of Splicing Kinetics and Transcript Elongation Rates in Mammalian Cells"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA Processing and Modifications
Discussion Leader: Steve Knutson (Emory University, USA)
7:30 pm - 7:40 pm
Jose Mario Pineda (Fred Hutchinson Cancer Research Center, USA)
"Most Human Introns Are Recognized via Multiple and Tissue-Specific Branchpoints"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Nicole Martinez (Yale University, USA)
"Pseudouridine Synthases Modify Human Pre-mRNA Co-Transcriptionally and Affect Splicing"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Nandan Gokhale (Duke University Medical Center, USA)
"The Role of N6-Methyladenosine in RNA Virus Infection"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Stephanie Moon (Howard Hughes Medical Institute / University of Colorado Boulder, USA)
"Single Molecule Imaging of mRNA Behavior Reveals Heterogeneous Dynamic Interactions with Stress Granules and P-Bodies in Human Cells"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Daphna Nachmani (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"NPM1 Germline and Somatic Mutations Demonstrate a Central Role for Ribosomal RNA Methylation in Hematopoiesis and Cancer"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Clare Miller (University at Albany, SUNY, USA)
"Moonlighting Function of Glycogen Synthase 1 in RNA Metabolism"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
RNA Translation / Mentorship Component: Discussion with Academic and Industry Leaders
Discussion Leader: Sonia Chothani (Duke-NUS Medical School, Singapore)
9:00 am - 9:10 am
Massimiliano Clamer (Immagina Biotechnology s.r.l., Italy)
"Active Ribosome Profiling with RiboLace"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Junhong Choi (Stanford University, USA)
"The Energy Landscape of Ribosomal Frameshifting"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Jacob Freimer (University of California, San Francisco, USA)
"Decoupling the Impact of microRNAs on Translational Repression Versus RNA Degradation in Embryonic Stem Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Gregg Rice (Novartis Institutes for BioMedical Research, USA)
"RNA Structure Centric Machine Learning of Primary microRNA Biogenesis"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
An Informal Discussion with Academic and Industry Leaders
Angela Brooks (University of California, Santa Cruz, USA)
Stacy Horner (Duke University Medical Center, USA)
Razvan Nutiu (Novartis, USA)
Eric Van Nostrand (University of California San Diego, USA)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
RNA Processing in Human Disease
Discussion Leaders: Deanna Tiek (Georgetown University, USA) and Daniel Dominguez (Massachusetts Institute of Technology, USA)
1:30 pm - 1:45 pm
Emanuel Wyler (Max Delbrück Center for Molecular Medicine, Germany)
"Herpes Simplex Virus Infection Reveals Modulation of the NXF1 Retained Intron by SF3B4"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Nancy Martinez Montiel (Université de Sherbrooke, Canada)
"Reprogramming Splicing Events in Cancer Using New Small Molecules and an Innovative Bifunctional Oligonucleotide Technology"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Brittney Otero (University of Florida, USA)
"Dissecting the Transcriptome of the DM1 CNS"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes