SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Protein Trafficking and Secretion: Classical and Unconventional Pathways |
| Discussion Leader: Annik Prat (Clinical Research Institute of Montreal) |
7:40 pm - 8:02 pm | Thomas Braulke (University Medical Center Hamburg-Eppendorf)
"S1P functions in the biogenesis of lysosomes"
|
8:02 pm - 8:10 pm | Discussion |
8:10 pm - 8:32 pm | Janice Mayne (Univ. of Ottawa)
"PCSK9 and Protein Trafficking" |
8:32 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Emer Ferro (Univ. of Sao Paulo)
"Unconventional secretion of cytosolic peptidases"
|
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Edwin Levitan (Univ. Pittsburgh)
"Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture" |
9:25 pm - 9:30 pm | Discussion |
10:00 pm | General Informal Discussion with Refreshments |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Secretory Pathway From ER To Exit - Focus On Proinsulin And Diabetes |
| Discussion Leader: Gary Thomas (University of Pittsburgh School of Medicine) |
9:00 am - 9:22 am | Keynote Address: Donald Steiner (Univ. Chicago)
"Reflections on the past, present, and future directions"
|
9:22 am - 9:30 am | Discussion |
9:30 am - 9:52 am | William Balch (Scripps)
"Folding, processing and packaging of insulin"
|
9:52 am - 10:00 am | Discussion |
10:00 am - 10:22 am | Peter Arvan (Univ. Michigan)
"Dominant versus recessive blockade of protein export in the early secretory pathway"
|
10:22 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:22 am | Joshua Zimmerberg (NIH)
"Insulin regulation of Glut 4 trafficking"
|
11:22 am - 11:30 am | Discussion |
11:30 am - 11:52 am | Michele Solimena (Univ. Dresden)
"Dynamics of age distinct insulin secretory granules"
|
11:52 am - 12:00 pm | Discussion |
12:00 pm - 12:22 pm | Chris Rhodes (Univ. Chicago)
"Can inhibition of insulin secretion treat type 2 diabetes?"
|
12:22 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Developments In Proprotein Processing: PCs And Beyond |
| Discussion Leader: Richard Mains (U. Conn. Health Center) |
7:30 pm - 7:52 pm | Iris Lindberg (Univ. Maryland School of Medicine)
"Proprotein convertase inhibitors, activators, and chaperones"
|
7:52 pm - 8:00 pm | Discussion |
8:00 pm - 8:22 pm | Lakshmi Devi (Mount Sinai School of Medicine)
"Secretory pathway metallo-endopeptidases"
|
8:22 pm - 8:30 pm | Discussion |
8:30 pm - 8:52 pm | Betty Eipper (Univ. Conn. Health Center)
"Secretory granule biogenesis: Contributions from the cytosolic and lumenal sides"
|
8:52 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Mary Bittner (Univ. Michigan)
"A Nibbling Mechanism for the Clathrin-mediated Recycling of Secretory Granule Membrane after Exocytosis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Kelly Brant (Univ. Pittsburgh)
"Dysregulation of proprotein convertases by prostaglandin-endoperoxide synthase 2 (cyclooxygenase) contributes to malignant phenotype in non-small cell lung cancer cells" |
9:25 pm - 9:30 pm | Discussion |
10:00 pm | General Informal Discussion with Refreshments |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Imaging Techniques To Study Protein Processing, Trafficking, And Secretion |
| Discussion Leaders: Ronald W. Holz (Univ. Michigan) and Daniel Constam (Ecole Polytechnique Fédérale de Lausanne |
9:00 am - 9:22 am | Erik L. Snapp (Albert Einstein College of Medicine)
"Imaging techniques to study protein processing and quality control in living cells" |
9:22 am - 9:30 am | Discussion |
9:30 am - 9:52 am | Thomas F.J. Martin (Univ. Wisconsin)
"Imaging lipids and lipid-linked protein regulators at sites of vesicle exocytosis"
|
9:52 am - 10:00 am | Discussion |
10:00 am - 10:22 am | Arun Anantharam (Wayne State)
"Real-time investigation of plasma membrane deformations and fusion pore expansion using pTIRFM"
|
10:22 am - 10:30 am | Discussion |
10:30 am | Group Photo / Coffee Break |
11:00 am - 11:22 am | Edward L. Stuenkel (Univ. Michigan)
"FRET-based studies to determine the sequence of protein interactions in the secretory pathway"
|
11:22 am - 11:30 am | Discussion |
11:30 am - 11:52 am | Robert H. Chow (Univ. Southern California)
"Using light to control cell secretion"
|
11:52 am - 12:00 pm | Discussion |
12:00 pm - 12:22 pm | Daniel Mesnard (Ecole Polytechnique Fédérale de Lausanne)
"Imaging paracrine proprotein convertase activities"
|
12:22 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Carboxypeptidases In Peptide Processing And Disease |
| Discussion Leader: Y. Peng Loh (NIH) |
7:30 pm - 7:50 pm | Peter Lyons (Manhattan College)
"Metallocarboxypeptidases from A to Z" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Rina Rosin-Arbesfeld (Tel Aviv Univ.)
"CPE: A negative regulator of the canonical Wnt signaling pathway"
|
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | William Wetsel (Duke)
"Regulation of mood and emotional responses in CPE-deficient mice"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Yong Cheng (NIH)
"CPE neuroprotects hippocampal neurons via Akt-Bcl2 signaling pathway"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Carolyn Worby (UCSD)
"Identification of a Family of Secreted Protein Kinases"
|
9:25 pm - 9:30 pm | Discussion |
10:00 pm | General Informal Discussion with Refreshments |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Protein Trafficking And Signaling |
| Discussion Leaders: Jan Christian (Univ. Utah) and Yanzhuang Wang (Univ. Michigan) |
9:00 am - 9:22 am | Scott Emr (Cornell)
"TOR kinase signaling cascade regulates endocytosis and plasma membrane protein turnover"
|
9:22 am - 9:30 am | Discussion |
9:30 am - 9:52 am | Christof Niehrs (Institute for Molecular Biology, Mainz)
"Regulation of Wnt signaling by endocytic trafficking"
|
9:52 am - 10:00 am | Discussion |
10:00 am - 10:22 am | Loydie Jerome-Majewska (McGill Univ.)
"Expression of the p24/Tmed vesicular protein trafficking genes and requirement during embryogenesis"
|
10:22 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:22 am | Mihaela Serpe (NIH)
"Drosophila NMJ synapse assembly"
|
11:22 am - 11:30 am | Discussion |
11:30 am - 11:52 am | Julie Brill (The Hospital for Sick Children - SickKids)
"A sorted tale: PI4KII promotes fidelity of regulated secretory granule trafficking in Drosophila"
|
11:52 am - 12:00 pm | Discussion |
12:00 pm - 12:22 pm | Kristi A. Wharton (Brown Univ.)
"Alternative proconvertase processing impacts BMP signaling output" |
12:22 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Hot Topics in Proprotein Processing, Trafficking, and Secretion |
| Discussion Leader: John Creemers (KU Leuven) |
7:30 pm - 7:45 pm | Rajat Singh (Albert Einstein College of Medicine)
"Autophagy in hypothalamic POMC neurons in the regulation of energy balance"
|
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Jonathan Bogan (Yale)
"Endoproteolytic cleavage of TUG regulates GLUT4 glucose transporter translocation" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Mark Rizzo (Univ. Maryland)
"Defects in the kinetics of insulin secretory vesicle fusion and first phase insulin release in sweet taste receptor knockout mice" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 9:30 pm | TBA (Short talks selected from posters) |
10:00 pm | General Informal Discussion with Refreshments |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genetics And The Secretory Pathway |
| Discussion Leaders: Robert Fuller (Univ. Michigan) and Paul Taghert (Washington Univ.) |
9:00 am - 9:22 am | John Creemers (KU Leuven)
"PREPL and post-Golgi membrane trafficking; lessons learned from patients and mice"
|
9:22 am - 9:30 am | Discussion |
9:30 am - 9:40 am | Jingshi Shen (Univ. Colarado, Boulder)
"A novel haploid genetics approach to dissect the trafficking of GPI-anchored proteins"
|
9:40 am - 9:45 am | Discussion |
9:45 am - 10:07 am | Christian Wegener (Univ. of Würzburg)
"A combined peptidomic-genetic approach to peptide processing in Drosophila"
|
10:07 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Derek Sieburth (Univ. Southern California)
"Neuropeptide Secretion Couples a Pacemaker to Rhythmic Behaviors in C. elegans"
|
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:22 am | Deborah Andrew (Johns Hopkins Univ.)
"Transcriptional regulation of secretory capacity and secretory cargo in the Drosophila salivary gland, and beyond"
|
11:22 am - 11:30 am | Discussion |
11:30 am - 11:52 am | Michael L. Nonet (Washington Univ.)
"A specialized pathway for peptidergic secretion in the C. elegans intestine"
|
11:52 am - 12:00 pm | Discussion |
12:00 pm - 12:22 pm | Jason C. Mills (Washington Univ.)
"'Scaling Factors' and the transcriptional network regulating secretory cell architecture"
|
12:22 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session IV |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Proprotein Processing, Trafficking And Secretion In Disease |
| Discussion Leader: An Zhou (Morehouse School of Medicine) |
7:30 pm - 7:52 pm | Robert Day (Univ. Sherbrooke)
"Peptide based proprotein convertase inhibitors: Potential applications for cancer"
|
7:52 pm - 8:00 pm | Discussion |
8:00 pm - 8:22 pm | Nabil G. Seidah (Clinical Research Institute of Montreal)
"Furin and PC5 exert opposite functions on selected substrates --- relationship to cancer/metastasis and liver regeneration"
|
8:22 pm - 8:30 pm | Discussion |
8:30 pm - 8:52 pm | Majid Khatib (Inserm, Bordeaux, France)
"Furin in cancer and rheumatoid arthritis: Lessons from in vivo studies"
|
8:52 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Gunjan Joshi (Univ. Michigan)
"Effect of beta-amyloid on Golgi fragmentation and APP trafficking in Alzheimer's disease" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Somshuvra Mukhopadhyay (Carnegie Mellon Univ.)
"Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga-induced death" |
9:25 pm - 9:30 pm | Discussion |
10:00 pm | General Informal Discussion with Refreshments |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |