Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Fundamental Principles of Protein Engineering
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"Innovation by Evolution: Bringing New Chemistry to Life"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Protein Engineering: the Endless Frontier"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Engineering of Optical Biosensors to Illuminate the Biochemical Activity Architecture of the Cell"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Genetically Encoded Bioluminescent-Fluorescent Integrators of Cell Signaling Dynamics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Biospecific Chemistry for Covalent Linking of Proteins with Biomacromolecules"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"New Luciferases, Luciferins, and Bioluminescent Sensors"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Directed Evolution for Enzyme Optimization
7:30 pm - 8:00 pm
"When Directed Evolution Met Ancestral Enzyme Resurrection"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Protein Engineering for Enzymatic Oligomerization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Extensive Protein Evolution on Laboratory Timescales"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Rational Design of New to Nature Proteins
9:00 am - 9:30 am
"Informing Rational Enzyme Design Using FAIR Practices"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Computational Design of Enzymes Through Coevolution and Correlation-Mediated Allosteric Networks"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Protein Engineering Using Consensus Information, Sequence Covariance and Machine Learning"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Exploring Novel Proteins via Rule-Based Approaches"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
AI for Protein Engineering
7:30 pm - 8:00 pm
"How AI is Influencing Protein Engineering"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Inverting Structure Predictions Model for Protein Design"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Functional Alignment of Protein Language Models with Reinforcement Learning"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biocatalysis and Industrial Applications
9:00 am - 9:30 am
"Protein Engineering Unlocks Biocatalytic Processes for Drug Synthesis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Protein Engineering for Cascade Biocatalysis: Enantioselective Synthesis of Some Selected Chiral Chemicals"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Engineering Next-Generation Oxidative Biocatalysts in E.coli and P. pastoris "
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Deep Learning-Guided Protein Directed Evolution"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Engineering for Synthetic Biology
7:30 pm - 8:00 pm
"From Code to Compound: Hacking Polyketide Synthases for Custom Chemistry"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Reprogramming Deaminase Specificity for Precise Genome Editing"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Enhance Synthetic Biology Using Machine-Guided Protein Engineering"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Protein Engineering for Immunotherapy and Other Diseases
9:00 am - 9:30 am
"Synthetic Receptor and Cas13 Circuits for Controlling Mammalian Cell Function"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"High-Throughput Mapping Immune Recognition by Synthetic Biology and Single-Cell Genomics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Engineering CRISPR for Precision Medicine"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Bidirectional Tuning of CAR Signaling via a Functional Switch Motif"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Sonogenetic Engineering for Next-Generation CAR-T Cell Therapy"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Repurpose Proteins for Novel Chemistry and Applications
7:30 pm - 8:00 pm
"Unlocking New-to-Nature Transition Metal Catalysis in Nonheme Enzymes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Next-Gen Genomically Recoded Organisms for Multi-Functionalization of Synthetic Proteins & Polymers"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Protein and Antibody Engineering Empowered by Uncertainty Aware AI/ML Models"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure