| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:10 pm | New and Old Views of Protein Folding |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader: Robert Baldwin (Stanford University) |
| 7:40 pm - 8:25 pm | Ken Dill (University of California, San Francisco)
"Modeling Fast Protein Folding" |
| 8:25 pm - 9:10 pm | Peter Wolynes (University of California, San Diego)
"Why Change Has Been Good: Successes of the 'New' View of Protein Folding" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Two and Three State Folding and f Analysis |
| 9:00 am - 9:10 am | Introduction by Discussion Leader: C. Robert Matthews (University of
Massachusets) |
| 9:10 am - 9:55 am | Alan Fersht (Cambridge University)
"Ultrafast Folding Proteins" |
| 9:55 am - 10:40 am | Mikael Oliveberg (Umeâ University)
"Is the Folding Energy Landscape Evolved to Maximise Cooperativity?" |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:45 am | Eugene Shakhnovich (Harvard University)
"Constructing, Verifying, and Dissecting Transition States in Protein Folding: Role of Topology and Structure" |
| 11:45 am - 12:30 pm | Susan Marqusee (University of California, Berkeley)
"Comparing the Folding Landscapes: Mesophiles, Thermophiles, and Circular Permutants" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:10 pm | Residual Structures in Unfolded Proteins |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader: Kara Bren (University of Rochester) |
| 7:40 pm - 8:25 pm | Ivano Bertini (University of Florence)
"The Role of the Metallic Cofactor in the Unfolding Process of Metalloprotiens by GdmCl. An NMR Investigation" |
| 8:25 pm - 9:10 pm | Peter Wright (The Scripps Research Institute)
"Structural and Dynamic Characterization of Apomyoglobin Folding Pathways and Intermediates" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Peptide Dynamics and Secondary Structure Formation |
| 9:00 am - 9:10 am | Introduction by Discussion Leader: Niels Andersen (University of Washington) |
| 9:10 am - 9:55 am | William Eaton (National Institutes of Health)
"Successes and Failures of Simple Models for Protein Folding" |
| 9:55 am - 10:40 am | Charles Brooks, III (The Scripps Research Institute)
"Protein Folding Mechanism and Thermodynamics from Theory and Simulation" |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:45 am | R. Brian Dyer (Los Alamos National Laboratory)
"Time Resolved Infrared Studies of Secondary Structural Dynamics" |
| 11:45 am - 12:30 pm | Luis Serrano (EMBL)
"De novo Designed Peptide-Based Amyloid Fibrils" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:25 pm | Computation and Design |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader: Harold Scheraga (Cornell University) |
| 7:40 pm - 8:15 pm | William Swope (IBM)
"IBM's BlueGene Protein Project: Early Results from the Scientific Program" |
| 8:15 pm - 8:50 pm | Vijay Pande (Stanford University)
"Atomistic Simulations of Protein Folding on the Tens of Microseconds Timescale Using Worldwide Distributed Computing" |
| 8:50 pm - 9:25 pm | Valerie Daggett (University of Washington)
"Protein Unfolding/Folding at Atomic Resolution" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Early Events in Protein Folding |
| 9:00 am - 9:10 am | Introduction by Discussion Leader: David Kliger (University of
California, Santa Cruz) |
| 9:10 am - 9:55 am | Heinrich Roder (Fox Chase Cancer Center)
"Structural Properties and Mechanistic Role of Early Intermediates in
Protein Folding" |
| 9:55 am - 10:40 am | José Onuchic (University of California, San Diego)
"Protein Folding Landscapes. Theory Connecting with Experiments" |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:45 am | S. Walter Englander (University of Pennsylvania)
"Testing the Initial Barrier Hypothesis" |
| 11:45 am - 12:30 pm | Martin Gruebele (University of Illinois)
"The Uphills and Downhills of Fast Folding" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | In vivo Folding: Molecular Chaperones and Proteases |
| 7:30 pm - 7:40 pm | Introduction by Discussion Leader: Robert Sauer (MIT) |
| 7:40 pm - 8:25 pm | Ulrich Hartl (Max Planck Institut für Biochemie)
"Mechanisms of Chaperone-Assisted Protein Folding" |
| 8:25 pm - 9:10 pm | David Agard (University of California, San Francisco)
"Impact of Protein Folding Landscapes on Biological Function: Longevity through Kinetic Stability" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | New Frontiers in Biopolymer Folding Research |
| 9:00 am - 9:10 am | Introduction by Discussion Leader: Andy Robertson (University of Iowa) |
| 9:10 am - 9:55 am | Xiaowei Zhuang (Harvard University)
"Watching Enzymes Fold One Molecule at a Time" |
| 9:55 am - 10:40 am | Patricia Jennings (University of California, San Diego)
"Folding, Unfolding, and Structural Plasticity in a Beta-Trefoil Protein" |
| 10:40 am - 11:00 am | Coffee Break |
| 11:00 am - 11:45 am | David Baker (University of Washington)
"Prediction and Design of Protein Structures and Folding Mechanisms" |
| 11:45 am - 12:30 pm | Dev Thirumalai (University of Maryland)
"What Can You Learn by Stretching Proteins?" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 5:00 pm - 6:00 pm | Business Meeting |
| 6:00 pm | Dinner |
| 8:00 pm - 9:10 pm | Protein Folding and Disease |
| 8:00 pm - 8:10 pm | Introduction by Discussion Leader: Jane Clarke (Cambridge University) |
| 8:10 pm - 9:10 pm | Chris Dobson (Cambridge University)
"The Links between Protein Folding and Human Disease" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
