SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE SESSION I |
| Discussion Leader: Jane Clarke (University of Cambridge) |
7:30 pm - 8:20 pm | Peter Wolynes (University of California, San Diego)
"Recent Successes of the Energy Landscape Theory of Protein Folding" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:20 pm | Jeffery Kelly (Scripps Research Institute)
"Backbone Mutations to Probe H-bond Energetics in Folding and Misfolding" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | FOLDING AND AGGREGATION |
| Discussion Leader: Sheena Radford (University of Leeds) |
9:10 am - 9:40 am | Valerie Daggett (University of Washington)
"Simulation of Conformational Changes Associated with Amyloidosis" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Yugi Goto (Osaka University)
"Comparison of Protein Folding and Amyloid Fibril Formation" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:05 am | William Swope (IBM Almaden Research Center)
"Computer Simulations of Peptides and Small Proteins" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Thomas Jahn (University of Leeds)
"Amyloid Fibril Formation Proceeds Via Trapped Protein Folding Intermediates" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Carol Hall (North Carolina State University)
"Molecular Dynamics Simulation of Fibril Formation" |
12:00 pm - 12:10 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PROTEIN EVOLUTION |
| Discussion Leader: Zan Luthey-Schulten (University of Illinois, Urbana-Champaign) |
7:40 pm - 8:05 pm | Cyrus Chothia (MRC LMB)
"Sequence Divergence: Limitations and Effects" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Teresa Head Gordon (University of California, Berkeley)
"Designing Sequences to Fold or Aggregate using the Denatured State Ensemble" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Sarah Teichmann (MRC LMB)
"Evolution of Multi-Domain Proteins" |
9:15 pm - 9:30 pm | Discussion / General Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | INVESTIGATING SPECIES ON THE FOLDING PATHWAY |
| Discussion Leader: Joan Shea (University of California, Santa Barbara) |
9:10 am - 9:40 am | Dan Raleigh (State University of New York, Stony Brook)
"The Role of the Unfolded State in Protein Folding and Stability" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Michele Vendruscolo (University of Cambridge)
"Determination of Ensembles of Structures Representing the Dynamics of Proteins" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:05 am | Sarah Batey (University of Cambridge)
"Cooperative Folding in a Multidomain Protein" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Jin Wang (State University of New York, Stony Brook)
"Diffusion Dynamics of Protein Folding" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Peter Wright (Scripps Research Institute)
"Mapping the apomyoglobin folding landscape by NMR: New insights into folding intermediates" |
12:00 pm - 12:10 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 8:15 pm | INVESTIGATING SPECIES ON THE FOLDING PATHWAY (continued) |
| Discussion Leader: Joan Shea (University of California, Santa Barbara) |
7:30 pm - 8:00 pm | Harold Scheraga (Cornell University)
"Computation of Protein Folding Pathways using Molecular Dynamics with a United-Residue (UNRES) Model of Polypeptide Chains" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 9:30 pm | KEYNOTE SESSION II |
| Discussion Leader: Charles Brooks (Scripps Research Institute) |
8:15 pm - 9:10 pm | Chris Dobson (University of Cambridge)
"Protein Folding & Human Disease" |
9:10 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | EXPLORING THE FOLDING LANDSCAPE I |
| Discussion Leader: Kevin Plaxco (University of California, Santa Barbara) |
9:10 am - 9:40 am | José Onuchic (University of California, San Diego)
"The Energy Landscape for Protein Folding and Function" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Mikael Oliveberg (University of Stockholm)
"Panning for the minimal protein folding nucleus through loop-entropy perturbations" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:05 am | Michelle DeRitter (University of Pennsylvania)
"Ultrafast Folding of Trp Cage Mini Proteins" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Elisha Haas (Bar Ilan University)
"Non Local Interactions are Effective Key Contributions to the Structure of Early Folding Intermediates" |
11:25 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Eugene Shakhnovich (Harvard University)
"Protein Folding Dynamics: A Global View from High-Resolution All Atom Simulations with Transferable Potentials" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | EXPLORING THE FOLDING LANDSCAPE II |
| Discussion Leader: Angel Garcia (Rensselaer Polytechnic Institute) |
7:40 pm - 8:10 pm | Phil Dawson (Scripps Research Institute)
"Unnatural backbone and side chain structures: an expanded toolkit for protein engineering" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Miriam Friedel (University of California, Santa Barbara)
"Tethering a protein to a surface changes its folding mechanism" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:10 pm | Vijay Pande
"Simulating Folding and Misfolding in Biological Contexts" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | FAST AND EARLY EVENTS / SINGLE MOLECULE FOLDING STUDIES |
| Discussion Leader: Tobin Sosnick (University of Chicago) |
9:10 am - 9:40 am | Bill Eaton (National Institutes of Health)
"Ultrafast Folding" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Steve Hagen (University of Florida)
"Diffusion and Friction-Limited Folding in Small Proteins" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:20 am | Susan Marqusee (University of California, Berkeley)
"Single Molecule Studies of Protein Folding using the Optical Tweezers" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Gilad Haran (Weizmann Institute)
"Probing Collapse and Folding Transitions with Single-Molecule Fluorescence" |
12:00 pm - 12:10 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FOLDING IN THE CELL |
| Discussion Leader: Amnon Horovitz (Weizmann Institute) |
7:40 pm - 8:10 pm | Silvia Cavagnero (University of Wisconsin, Madison)
"Protein Folding as a Function of Chain Elongation: Off and On the Ribosome" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Beena Krishnan (University of Massachusetts, Amherst)
"Developing New Strategies to Monitor In Vivo Protein Folding" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:10 pm | Art Horwich (Yale University)
"The Chaperonin Reaction: Observing Substrate Proteins" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |