SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Lectures |
| Discussion Leader: Harold Scheraga (Cornell University) |
7:40 pm - 8:15 pm | Charlie Brooks (University of Michigan)
"Simulation studies of protein folding from conformational networks to protein function" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:05 pm | Bill Eaton (National Institutes of Health)
"Ultrafast protein folding: from ensembles to single molecules" |
9:05 pm - 9:20 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Navigating the Energy Landscape |
| Discussion Leader: Sheena Radford (University of Leeds) |
9:10 am - 9:35 am | Doug Barrick (Johns Hopkins University)
"Measurement of long-range coupling energetics and contribution to protein folding kinetics" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Dan Raleigh (SUNY Stony Brook)
"Unfolded states under native conditions: Not a random coil" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break / Group Photo |
10:45 am - 11:10 am | Peter Wolynes (University of California, San Diego) |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Wei Wang (Nanjing University)
"Protein Folding Mediated by Cofactors" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Mikael Oliveberg (Stockholm University)
"Functional frustration in the ALS-associated protein SOD1" |
12:05 pm - 12:15 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Molecular Machines: Dynamics and Function |
| Discussion Leader: Jose Onuchic (University of California, San Diego) |
7:40 pm - 8:05 pm | Klaus Schulten (University of Illinois, Urbana-Champaign)
"Microsecond molecular dynamics simulations of protein folding - successes, failures, and challenges" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Changbong Hyeon (Chung-Ang University, Korea)
"Understanding the principles of molecular nanomachines" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Lorna Dougan (University of Leeds)
"Identifying the role of the solvent environment in protein folding" |
9:15 pm - 9:25 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Fluctuations in the native state |
| Discussion Leader: Ken Dill (University of California, San Francisco) |
9:10 am - 9:35 am | Jaime Fraser (University of California, Berkeley)
"Hidden Alternate Structures Essential For Catalysis" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Riina Tehver (University of Maryland)
"Myosin V Allostery: Link between the Dynamics and its Supporting Architecture" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Hue Sun Chan (University of Toronto)
"Interplay of Native Topology and Nonnative Interactions in Cooperative and Noncooperative Protein Folding" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Jane Dyson (The Scripps Research Institute)
"NMR Studies of Protein Folding Dynamics" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Ivet Bahar (University of Pittsburgh)
"Functional Dynamics of Proteins: Learning from Ensembles of Structures and Network Models" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | From Evolution to Pathways and Design |
| Discussion Leader: Jane Clarke (Cambridge University) |
7:40 pm - 8:05 pm | Eugene Shakhnovitch (Harvard University)
"Effect of protein folding on fitness landscape" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Frances Arnold (California Institute of Technology)
"How proteins adapt: lessons from laboratory evolution" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Tobin Sosnick (University of Chicago)
"Using the folding process to improve protein structure prediction" |
9:15 pm - 9:25 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Folding in vivo and off the ribosome |
| Discussion Leader: Joan Shea (University of California, Santa Barbara) |
9:10 am - 9:35 am | Andreas Mastoushek (Northwestern University)
"Substrate selection by the proteasome" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Patricia Clark (University of Notre Dame)
"The Influence of Translation on Protein Folding" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Judith Frydman (Stanford University)
"Mechanisms of chaperone-assisted protein folding in the eukaryotic cytosol" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:45 am | George Lorimer (University of Maryland)
"Allosteric states and chaperonin assisted protein folding" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Johannes Buchner (Technische Universitaet München)
"Functional principles of molecular chaperones" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Pushing the Limits |
| Discussion Leader: Matthias Reif |
7:40 pm - 8:05 pm | Vijay Pande (Stanford University)
"Insights from all-atom simulations of folding on the millisecond timescale and beyond" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Ruxandra Dima (University of Cincinnati)
"Exploring factors that determine the mechanical response of proteins: from globular proteins to protofilaments" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Josh Wand (University of Pennsylvania)
"Scraping the bottom of the funnel: dynamics, entropy and solvation in the native state" |
9:15 pm - 9:25 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Misfolding and Aggregation |
| Discussion Leader: Jennifer Lee (National Institutes of Health) |
9:10 am - 9:35 am | Phillip Geissler (University of California, Berkeley)
"Solvation, sterics, and side chains: Fluidity within proteins' native states" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Zoya Ignatova (University of Potsdam)
"Natural osmolytes modulate the aggregation pathway of polyglutamine proteins" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Yuji Goto (Osaka University)
"Amyloid fibril growth visualized by thioflavin T fluorescence and probed by H/D exchange" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:45 am | John Straub (Boston University)
"Exploring the role of sequence and environment in the early stages of the protein aggregation pathway" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Rob Tycko (National Institutes of Health)
"Characterization of Unfolded, Partially Folded, and Misfolded Proteins by Solid State NMR" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protein Energetics and Cosolvents |
| Discussion Leader: Walter Englander (University of Pennsylvania) |
7:40 pm - 8:10 pm | Rohit Pappu (Washington University, St. Louis)
"Conformational equilibria and 'phase' diagrams of intrinsically disordered polypeptides" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 8:40 pm | Ruhong Zhou (IBM Thomas J. Watson Research Center)
"Action of Urea: Molecular Picture of Protein Chemical Denaturing from Large Scale Simulations" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | George Makhatadze (Rensselaer Polytechnic Institute)
"Protein Stability and Cooperativity: Effects of Different Denaturing Factors" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |