From Protein Folding In Vitro to Hierarchical Assembly In Vivo

Proteins fold, unfold, dissociate from each other, or form hierarchical complexes in a living cell in response to external stimuli. What governs protein dynamics in vivo and how their molecular assembles relate to cellular function and dysfunction remain unsolved challenges. Because of the complexity of the problem, we will need an interdisciplinary approach – experiment, theory, and simulation – led by experts who engage in close collaboration. This integrated approach will guide hypothesis-driven experiments as well as validate theoretical predictions, which will greatly advance our fundamental understanding of protein folding dynamics in a cell. In this program, we aim to cover a wide range of topics from protein dynamics at a single-molecule level to molecular assembly at a subcellular scale. We will discuss recent developments in understanding rapid and elementary processes, such as the early stages of protein folding and the behavior of unfolded proteins in complex environments. We will leverage the emerging knowledge of collective protein dynamics in cells to characterize proteins' regulatory roles in transient processes that promote cellular function. The conference has a successful track record in mentoring and retaining early career scientists and graduate students. To include early-career scientists, the program is being developed in close collaboration with the co-chairs of the Gordon Research Seminar (GRS). We anticipate that this meeting will continue to serve as the key venue for scientific exchange at the forefront of protein folding dynamics research, for bridging theoretical and experimental approaches, for including diverse topics, and for promoting and mentoring young scientists.