Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Amyloids and Aging
Discussion Leaders: Emery Usher (Washington University in St. Louis, United States) and Bernd Bukau (ZMBH, Heidelberg University, Germany)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Tuomas Knowles (University of Cambridge, United Kingdom)
"Dynamics of Protein Phase Transitions"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Pernilla Wittung-Stafshede (Chalmers University of Technology, Sweden)
"Alpha-Synuclein Amyloids: Inhibition, Mechanism and Activity"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein Dynamics in the Cell
Discussion Leaders: Christian Kaiser (Johns Hopkins University, United States) and Taras Pogorelov (University of Illinois at Urbana-Champaign, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Zaida Luthey-Schulten (University of Illinois at Urbana-Champaign, United States)
"Simulating a Growing Minimal Cell: A Integration of Theory and Experiment"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Erik Lindahl (Stockholm University, Sweden)
"Multiple (meta)Stable Conformations as the Basis of Functional Cycles in Membrane Proteins"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Gary Pielak (University of North Carolina at Chapel Hill, United States)
"Protein Stability in Cells & Under Crowded Conditions In Vitro "
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
Bernd Bukau (ZMBH, Heidelberg University, Germany)
"Mechanisms of Co-Translational Folding and Assembly of Proteins"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Silvia Cavagnero (University of Wisconsin Madison, United States)
"Unavoidable Disasters: the Hsp70 Chaperone Is an Imperfect Aggregation-Preventing Machine"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Edward O'Brien (Penn State University, United States)
"A Newly Predicted Class of Protein Misfolding Explains Decades Old Biophysical Data"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Pernilla Wittung-Stafshede (Chalmers University of Technology, Sweden) and Gregory Bowman (University of Pennsylvania, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteins Under Stress
Discussion Leaders: Lauren Buchanan (Vanderbilt University, United States) and Shahar Sukenik (University of California, Merced, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Ellinor Haglund (University of Hawaii at Manoa, United States)
"Folding and Misfolding of Complex Topologies"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Jerson Silva (Federal University of Rio de Janeiro, Brazil)
"Biomolecular Condensation and Amyloid Aggregation in Cancer"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Andrei Tokmakoff (University of Chicago, United States)
"The Dynamics of Insulin Dimer Association Viewed Through IR Spectroscopy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Shahar Sukenik (University of California, Merced, United States)
"Who Lives and Who Dries? Molecular Determinants of Protein Desiccation Survival"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Intrinsically Disordered Proteins, Phase Separation and Aging
Discussion Leaders: Kresten Lindorff-Larsen (University of Copenhagen, Denmark) and Rebecca Berlow (University of North Carolina at Chapel Hill, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Tanja Mittag (St. Jude Children's Research Hospital, United States)
"Fibrillization and Dynamical Arrest of Prion-Like Domain Condensates"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Birthe B. Kragelund (University of Copenhagen, Denmark)
"The Role of Stereochemistry in Disordered Protein Complexes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Paul Robustelli (Dartmouth College, United States)
"Molecular Recognition Mechanisms of Intrinsically Disordered Proteins"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
Kingshuk Ghosh (University of Denver, United States)
"Physical Mathematics Gives Insights to Sequence-Conformation-Function Relation in IDPs"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
Priya Banerjee (University at Buffalo, State University of New York, United States)
"Dynamics of Aging Protein Condensates"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Rosana Collepardo (University of Cambridge, United Kingdom)
"Multiscale Simulations of Chromatin Liquid-Like Organization"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Probing Protein Folding, Misfolding and Aggregation at the Single Molecule Level
Discussion Leaders: Pilar Cossio (Flatiron Institute, United States) and Gilad Haran (Weizmann Institute of Science, Israel)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Michael Woodside (University of Alberta, Canada)
"Observing Templated Propagation of Protein Misfolding in Single Molecules"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Susan Marqusee (University of California, Berkeley, United States)
"Exploring Sequence Constraints on the Kinetic Barriers to Conformational Exchange"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Hoi Sung Chung (National Institutes of Health, United States)
"Single-Molecule Fluorescence Spectroscopy of Amyloid-ß Aggregation"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Birgit Strodel (Forschungszentrum Jülich GmbH, Germany)
"Exploring Energy Landscapes of Protein Aggregation and Conformation Switching in Intrinsically Disordered Proteins"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Dynamics
Discussion Leaders: Michelle Arkin (University of California, San Francisco, United States) and James Fraser (UCSF, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Gregory Bowman (University of Pennsylvania, United States)
"Disorder and Dysfunction in ApoE and Alzheimer's Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Denise Okafor (Pennsylvania State University, United States)
"Allosteric Mechanisms of Transcriptional Control in FXR"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Pilar Cossio (Flatiron Institute, United States)
"Good Rates from Bad Coordinates"
10:55 am - 11:05 am
Discussion
11:05 am - 11:20 am
Short Talk Selected from Poster Abstracts
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Nikolay Dokholyan (Penn State College of Medicine, United States)
"NanoComputing Agents: Hacking Cellular Behavior"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Catherine Royer (Rensselaer Polytechnic Institute, United States)
"Mapping the Nucleotide Switch Transition in Arf GTPases"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Protein Folding and Dynamics
Discussion Leader: Jonathan Schlebach (Indiana University, Bloomington, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Karen Fleming (Johns Hopkins University, United States)
"Adventures in Membrane Protein Folding"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Abhishek Singharoy (Arizona State University, United States)
"Probing Molecular Dynamics with Policy Planning Algorithms Resolves the Disordered Regions of Protein Supercomplexes"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Rebecca Voorhees (California Institute of Technology, United States)
"Quality Control of Orphan Membrane Protein Subunits"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Nicholas Noinaj (Purdue University, United States)
"BAM Orchestrates OMP Biogenesis Using a ß-templating Mechanism"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Protein Evolution and Design
Discussion Leaders: Jesse Bloom (Fred Hutchinson Cancer Center, United States) and Liskin Swint-Kruse (University of Kansas Medical Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Tanja Kortemme (UCSF, United States)
"De novo Design of Diverse Protein Geometries and Tunable Protein Switches"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Lauren Porter (National Institutes of Health, United States)
"Exploring Unknown Regions of Protein Fold Space"
9:55 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Debora Marks (Harvard Medical School, United States)
"Can AI Design and Predict Alternative Protein States?"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Michael Harms (University of Oregon, United States)
"Kicking and Screaming Stochastic Protein Evolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Brian Kuhlman (University of North Carolina at Chapel Hill, United States)
"Protein Stability Prediction and Design Using Deep Learning Models"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Mikael Oliveberg (Stockholm University, Sweden)
"Protein Evolution in Different Cytoplasm Environments"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Viral Folding, Assembly, Evolution
Discussion Leaders: Fatema Bhinderwala (University of Pittsburgh, United States) and Erik Holmstrom (University of Kansas, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:20 pm
Shachi Gosavi (National Centre for Biological Sciences, India)
"Steps Enroute to the Assembly of Simple RNA Viruses"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Jesse Bloom (Fred Hutchinson Cancer Center, United States)
"Interpreting the Evolution of SARS-CoV-2"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure