Protein Dynamics of Aging, Stress and Evolution

While many of the basic features of in vitro folding are understood thanks to decades of experimental, computational and theoretical work, the process remains a complex one with many facets important for understanding protein evolution, creating new biomedical applications, and building up a dynamical picture of the full proteome. In this conference, we will bring together leading experts in protein science who study structure from disordered proteins to large membrane assemblies, dynamics from nanoseconds to days, misfolding and aggregation, protein-protein interactions from complexes to phase-separated regions in the context of evolution, dynamics, and cell biology. Topics range widely from amyloids to proteins in extreme environments to phase separation. We try to understand the principles behind protein design, structure prediction of dynamical complexes, interaction of proteins with drug molecules, and many other facets where protein dynamics and folding play a critical role.