Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Finding the Bottom of the Funnel: Protein Folding Pathways
Discussion Leaders: Natalie Dall (UC Berkeley, United States) and Rishav Mitra (University of Michigan, United States)
3:45 pm - 3:55 pm
Amir Bitran (Harvard University, United States)
"Co-Translational Folding Allows Misfolding-Prone Proteins to Circumvent Deep Kinetic Traps"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Wyel Halimeh (Wichita State University, United States)
"Dependence of Proline Isomerization on the Kinetics of Folding of Anthrax Lethal Factor"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Jennifer Simien (University of Hawaii at Manoa, United States)
"Unravelling the Folding and Threading Mechanism of the “Knot-Like” Topology in Leptin"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dynamics, Stability and Function
Discussion Leader: Zachary Smith (University of Maryland, United States)
7:30 pm - 7:40 pm
Ian Sitarik (Penn State University, United States)
"Near Native Misfolding into Semi- or Non-Functional States is Prevalent Across the Proteome"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Fatema Bhinderwala (University of Pittsburgh, United States)
"Structural studies of bio-hacking insect proteins"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Shawn Costello (UC Berkeley, United States)
"The SARS-CoV-2 Spike Reversibly Samples an Open-Trimer Conformation Exposing Novel Epitopes"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Kevin Jose Cheng (University of Illinois at Urbana-Champaign, United States)
"Encounters on The Membrane: The Role of Charged Peptides in Bilayer Disruption"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Upasana Mallimadugula (Washington University in St. Louis, United States)
"How Does Sequence Affect the Dynamics of a Cryptic Allosteric Site in Ebolavirus VP35?"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Claire Stewart (University of North Carolina at Chapel Hill, United States)
"Polyethylene Glycols and Protein Stability"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Oleta Johnson (UCSF, United States)
"Developing Tools to Probe DNAJB6 Dynamics in PolyQ Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Intrinsic Disorder, Complicated Landscapes and Methods to Explore Them
Discussion Leaders: Lu Hong (University of California, San Francisco, United States) and Xingcheng Lin (Massachusetts Institute of Technology, United States)
9:00 am - 9:10 am
Kathryn Lebold (NIH/NIDDK, United States)
"Tuning the Formation of Protein-Nucleic Acid Condensates"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Emery Usher (Washington University in St. Louis, United States)
"Determinants of E3 Ligase Adaptor SPOP Binding to Intrinsically Disordered Substrates"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Devlina Chakravarty (National Library of Medicine, United States)
"AlphaFold2 Fails to Predict Protein Fold Switching"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
David Jacobson (Clemson University, United States)
"Measuring Equilibrium Unfolding Free Energy Changes of Membrane Proteins by Single-Molecule Force Spectroscopy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Dedi Wang (University of Maryland, College Park, United States)
"Capturing Protein Conformational Dynamics through Information Bottleneck and Molecular Dynamics"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Darian Yang (University of Pittsburgh, United States)
"Integrating Fluorinated Amino Acids into the Framework of the AMBER ff15ipq Force Field"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Magdalena Topolska (Centre for Genomic Regulation Barcelona, Spain)
"Understanding the impact of indels on protein stability and function using deep mutational scanning"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Finding the Mentorship You Need to Succeed
Discussion Leader: Emma Carroll (UCSF, United States)
1:30 pm - 2:20 pm
Panel Discussion
Panel Discussion Finding the Mentorship You Need to Succeed
Anum Glasgow (Columbia University, United States)
Lauren Porter (National Institutes of Health, United States)
Angela Phillips (University of California, San Francisco, United States)
2:20 pm - 2:30 pm
General Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
