SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | Folding, Quality Control, and Activation in the Secretory Pathway |
| Discussion Leader: Peter Arvan (University of Michigan) |
7:35 pm - 8:00 pm | Keynote Address: Nabil Seidah (Clinical Research Institute of Montreal)
"The Proprotein Convertases: From Bench Discovery to Bedside Clinical Applications"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:32 pm | Matthew Freeman (University of Oxford)
"Control of Secretion and Trafficking by the Rhomboid-Like Superfamily"
|
8:32 pm - 8:40 pm | Discussion |
8:40 pm - 9:02 pm | Randal Kaufman (Sanford-Burnham Medical Research Institute)
"How Does Protein Misfolding in the ER Cause Cell Death" |
9:02 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Bas Brouwers (KU Leuven)
"Loss of Furin in β-Cells Leads to ER Stress and Impaired Glucose Homeostasis In Vivo"
|
9:25 pm - 9:30 pm | Discussion |
9:45 pm | General Informal Discussion with Refreshments |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Proprotein Convertases in Homeostasis and Pathologies |
| Discussion Leader: Robert Day (University of Sherbrooke) |
9:00 am - 9:22 am | Iris Lindberg (University of Maryland)
"Osteocyte FGF23 Biosynthesis"
|
9:22 am - 9:30 am | Discussion |
9:30 am - 9:52 am | Daniel Bassi (Fox Chase Cancer Center)
"Enhanced Carcinogenesis in Transgenic Mice Overexpressing Furin"
|
9:52 am - 10:00 am | Discussion |
10:00 am - 10:22 am | Torsten Steinmetzer (Philipps University Marburg)
"Design, Characterization and Use of Synthetic Inhibitors for Furin-Like PCs"
|
10:22 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:22 am | Geraldine Siegfried (INSERM U1029)
"Different Apelin Isoforms in Blood Vessels: Role of PCs"
|
11:22 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Manuel Than (Leibniz Institute for Age Research - FLI)
"Expression and Structural Studies of Human Furin in Complex with Competitive Inhibitors"
|
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Christine Levesque (Universite de Sherbrooke)
"PACE4 Inhibitors and Their Peptidomimetic Analogs Block Prostate Cancer Tumor Progression Through Quiescence Induction, Increased Apoptosis and Impaired Neovascularisation"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Elias Blanco (University of Maryland)
"Human PC1/3 Ser357Gly: A Mutant with PC2-Like Activity"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PCSK9: The Therapeutic Target for the Next Blockbuster Drug in Heart Disease?
|
| Discussion Leader: Annik Prat (Clinical Research Institute of Montreal) |
7:30 pm - 7:52 pm | Evan Stein (Metabolic and Atherosclerosis Research Center)
"Clinical Trials of Anti-PCSK9 Monoclonal Antibodies" |
7:52 pm - 8:00 pm | Discussion |
8:00 pm - 8:22 pm | Thomas Legacé (University of Ottawa Heart Institute)
"Cell-Type Specific Resistance to PCSK9-Mediated LDL Receptor Degradation:
Insights for Therapeutic PCSK9 Inhibition"
|
8:22 pm - 8:30 pm | Discussion |
8:30 pm - 8:52 pm | Trond Leren (Oslo University Hospital)
"PCSK9-Mediated Degradation of the LDL Receptor" |
8:52 pm - 9:00 pm | Discussion |
9:00 pm - 9:22 pm | Xiaowei Chen (University of Michigan)
"Cholesterol Regulation by the Secretory Pathways - A Tale of the COPII Complex"
|
9:22 pm - 9:30 pm | Discussion |
9:45 pm | General Informal Discussion with Refreshments |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NextGen and Omics Approaches to Study Posttranslational Modifications |
| Discussion Leader: Klaudia Brix (Jacobs University) |
9:00 am - 9:22 am | Stefan Lichtenthaler (Technical University Munich)
"Degradomic Tools for Identifying Protease Substrates In Vitro and In Vivo"
|
9:22 am - 9:30 am | Discussion |
9:30 am - 9:52 am | Marie Kveiborg (University of Copenhagen)
"A Functional Genomic Screen Identifies PACS-2 as a Novel Regulator of ADAM17 and EGFR Activity"
|
9:52 am - 10:00 am | Discussion |
10:00 am - 10:22 am | Martin Martin (UCLA)
"Role of NEUROG3 and PCSK1 in Human Enteroendocrine Cells"
|
10:22 am - 10:30 am | Discussion |
10:30 am | Group Photo / Coffee Break |
11:00 am - 11:22 am | Lloyd Fricker (Albert Einstein College of Medicine)
"Peptidomics Approaches to Study Protein Processing"
|
11:22 am - 11:30 am | Discussion |
11:30 am - 12:30 pm | Short Talks Selected from GRS Posters: |
|
- Mathilde Bonnemaison (UCHC)
- Anna Cmoch (Nencki Institute of Experimental Biology)
- Nathan Cox (Duke University - Department of Biochemistry)
- Kornelia Hardes (Philipps University Marburg)
- Peter Hoboth (Philipps University Marburg)
- Anna Kwiatkowska (Université de Sherbrooke)
- Kevin Ly (Université de Sherbrooke)
- Amulya Priya (Indian Institute of Science Education and Research)
- Raquel Salinas (Duke University)
- Rose Willet (University of Arkansas for Med Sci)
|
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Trafficking Pathways, Sorting and Intercellular Communication |
| Discussion Leader: Robert Fuller (University of Michigan) |
7:30 pm - 7:52 pm | Vivian Budnik (University of Massachusetts Medical School)
"Trans-Synaptic Signaling Through Exosomes" |
7:52 pm - 8:00 pm | Discussion |
8:00 pm - 8:22 pm | Wim Annaert (KU Leuven-VIB)
"Distinct Transport Itineraries of Presenilin1 AND 2-Complexes Contribute to Substrate Specificity/Accessibility"
|
8:22 pm - 8:30 pm | Discussion |
8:30 pm - 8:52 pm | Indira Mysorekar (Washington University School of Medicine)
"Regulation of Membrane Protein and Bacterial Trafficking in the Urinary Tract Epithelium by Autophagy"
|
8:52 pm - 9:00 pm | Discussion |
9:00 pm - 9:22 pm | Tanja Kögel (University of Bergen)
"Screening for the Mechanism of Contact-Dependent Intercellular Transfer"
|
9:22 pm - 9:30 pm | Discussion |
9:45 pm | General Informal Discussion with Refreshments |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Posttranslational Modifications in the Secretory Pathway and Extracellular Matrix
|
| Discussion Leader: Betty Eipper (University of Connecticut Health Center) |
9:00 am - 9:22 am | Vincent Tagliabracci (UCSD)
"Phosphorylation of Secreted Proteins by a New Family of Kinases"
|
9:22 am - 9:30 am | Discussion |
9:30 am - 9:52 am | Hans-Ulrich Demuth (Fraunhofer-Institute Leipzig)
"Secretion of Bioactive Chemokines Differentially Maintained by Glutaminyl Cyclases
in Inflammation and Neurodegeneration"
|
9:52 am - 10:00 am | Discussion |
10:00 am - 10:22 am | Maurine Linder (Cornell University)
"Mechanism and Consequences of DHHC Protein-S-Acyltansferases"
|
10:22 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:22 am | Tal Ilani (Weizmann Institute of Science)
"Putting Extracellular Matrix Pieces into Place with a Secreted Disulfide Catalyst"
|
11:22 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Kelly Ten Hagen (NIDCR/NIH)
"Protein O-Glycosylation in Polarized Secretion: New Insights and Real-Time Approaches"
|
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Seema Mattoo (Purdue University)
"A Novel Link Between Fic-Mediated Adenylylation and the Unfolded Protein Response"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Mark Henderson (NIH/NIDA)
"SERCaMP: A Secreted Reporter Protein to Monitor Perturbations in Endoplasmic Reticulum Calcium Homeostasis
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Golgi Apparatus Structure and Function |
| Discussion Leader: Gary Thomas (University of Pittsburgh) |
7:30 pm - 7:52 pm | Daniel Ungar (University of York)
"Linking Membrane Trafficking and Glycan Processing Through the COG Tethering Complex"
|
7:52 pm - 8:00 pm | Discussion |
8:00 pm - 8:22 pm | Masahiro Hosaka (Akita Prefectural University)
"Sorting Mechanisms of Prohormones from the Trans-Golgi Network to Secretory Granules: Concepts with Granin-Family Protein"
|
8:22 pm - 8:30 pm | Discussion |
8:30 pm - 8:52 pm | Tsuyoshi Watanabe (Asahikawa Medical College)
"Overall Shape of the Golgi Apparatus and Intracellular Organization of Secretory Cells: The Significance of the Spherical Golgi in the Pituitary Gonadotropes"
|
8:52 pm - 9:00 pm | Discussion |
9:00 pm - 9:22 pm | Yanzhuang Wang (University of Michigan)
"Golgi Structure, Formation, Function, and Defects in Diseases"
|
9:22 pm - 9:30 pm | Discussion |
9:45 pm | General Informal Discussion with Refreshments |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Granule Biogenesis and Secretion |
| Discussion Leader: Thomas Martin (University of Wisconsin-Madison) |
9:00 am - 9:30 am | Chris Rhodes (The University of Chicago Kovler Diabetes Center)
"Adaptive Plasticity in Pancreatic β-Cell" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:02 am | Ronald Holz (University of Michigan Medical School)
"Lumenal Protein Within Secretory Granules Controls Fusion Pore Expansion" |
10:02 am - 10:10 am | Discussion |
10:10 am - 10:32 am | Alan Attie (University of Wisconsin-Madison)
"Sorcs1: From Diabetes QTL to Cellular Function" |
10:32 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:10 am - 11:32 am | Aaron Turkewitz (The University of Chicago)
"Proprotein Processing in Tetrahymena Secretory Granules (Mucocysts) Involves Sortilin Receptor-Dependent Delivery of Aspartyl Cathepsins" |
11:32 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Francesco Ferraro (MRC-UCL)
"A Novel Function for the Golgi Ribbon: Modulation of Secretory Granule Activity Through Control of Its Size"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Joel da Palma (University of Lausanne)
"Arenaviruses Hijack Partially Activated SKI-1/S1P Precursors Present Early in the Secretory Pathway"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Edwin Levitan (University of Pittsburgh)
"Vesicle Capture, Not Delivery, Scales Up Neuropeptide Storage in Neuroendocrine Terminals"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Processing and the Regulated Secretory Pathway |
| Discussion Leader: Majid Khatib (INSERM U1029) |
7:30 pm - 7:52 pm | Richard Mains (University of Connecticut Health Center)
"PAM: So Much More Than a Peptide Biosynthetic Enzyme"
|
7:52 pm - 8:00 pm | Discussion |
8:00 pm - 8:22 pm | Peng Loh (NIH)
"Carboxypeptidase E (Neurotrophic Factor-α1) in Depression and Cancer"
|
8:22 pm - 8:30 pm | Discussion |
8:30 pm - 8:52 pm | Paul Taghert (Washington University in St. Louis)
"Molecular Organization of Dense Core Vesicles in Drosophila" |
8:52 pm - 9:00 pm | Discussion |
9:00 pm - 9:22 pm | Rina Rosin-Arbesfeld (Tel Aviv University)
"Mechanistic Insights into the Role of Carboxypeptidase E (CPE) in Modulation of the Wnt Signaling Pathway"
|
9:22 pm - 9:30 pm | Discussion |
9:45 pm | General Informal Discussion with Refreshments |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |