Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Next-Gen Protein Processing |
| This session is dedicated in memorium for Dr. Donald F. Steiner, M.D., who co-founded this GRC 22 years ago, and who passed away since the 2014 Conference. |
| Discussion Leader: Iris Lindberg (University of Maryland School of Medicine, USA) |
7:40 pm - 7:50 pm | Introduction by Discussion Leader: The Legacy of Don Steiner |
7:50 pm - 8:15 pm | Peter Arvan (University of Michigan Medical School, USA) "The Story of Proinsulin Continues to Unfold" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Robert Day (Université de Sherbrooke, Canada) "PCSK6 Undergoes an
Oncogenic Alternative Splicing Switch in Cancer" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Bertrand Cariou (L'Institut du Thorax, Centre Hospitalier Universitaire (CHU) de Nantes, France) "The Biology and Genetics of PCSK9" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Generation of the Endolysosomal Pathway |
| Discussion Leader: Richard Mains (University of Connecticut Health Center, USA) |
9:00 am - 9:25 am | Avital Rodal (Brandeis University, USA) "The Lowe Syndrome Phosphoinositide Phosphatase
dORCL Maintains Innate Immunity Quiescence by Regulating Endosomal Trafficking" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA) "Ultrafast Endocytosis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Phyllis Hanson (Washington University School of Medicine in St. Louis, USA) "ESCRT-III Function in Endosomal Trafficking" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Robert Fuller (University of Michigan, USA) "Molecular Functions and Structural Features of Vps13 and Its Role in Diverse Membrane Transactions" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Melkam Kebede (University of Sydney, Australia) "A Single Nucleotide Polymorphism in the Pro-Domain of Sorcs1 Affects Sorcs1 Protein Processing" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Majid Khatib (INSERM / University of Bordeaux, France) "Proprotein Convertases (PCs) Mediate Epstein-Barr Virus Infection Through Glycoprotein B Cleavage: Amplification and Positive Feedback Loop" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Edward Anderson (Brown University, USA) "Effect of Alternative BMP Processing on Signaling Activity, Prodomain Complexes, and Development" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Betty Eipper (University of Connecticut Health Center, USA) and Avital Rodal (Brandeis University, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Views on Peptide Processing and Release |
| Discussion Leader: Kelly Ten Hagen (National Institutes of Health, USA) |
7:30 pm - 7:55 pm | Robert Edwards (University of California, San Francisco, USA) "Membrane Protein Sorting to the Regulated Secretory Pathway" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Seung Kim (Stanford University School of Medicine / Howard Hughes Medical Institute, USA) "Suppression of Insulin Output by the Decretin Hormones Limostatin and Neuromedin U" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Jonathan Sweedler (University of Illinois at Urbana-Champaign, USA) "Heterogeneity in Peptide Processing Measured via High Throughput Single Cell Mass Spectrometry" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Duy Tran (National Institutes of Health, USA) "Imaging Secretory Granule Dynamics and Regulated Exocytosis In Vivo" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulated Intramembrane Proteolysis |
| Discussion Leader: Nabil Seidah (Institut de Recherches Cliniques de Montréal (IRCM), Canada) |
9:00 am - 9:25 am | Regina Fluhrer (BioMedizinische Zentrum der LMU München, Germany) "SPPL3 - An Intramembrane Aspartyl Protease with Exciting Properties" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Michael Glickman (Memorial Sloan-Kettering Cancer Center, USA) "Role of the Rip1 Intramembrane Protease in M. tuberculosis Stress Resistance" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Joanne Lemieux (University of Alberta, Canada) "Rhomboid-Mediated Intramembrane Proteolysis in the Mitochondrion" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:10 am | Bernd Schroder (Christian-Albrechts-Universität zu Kiel, Germany) "SPPL2-Mediated Intramembrane Proteolysis Controls Pro-Atherogenic Signaling of the Receptor LOX-1" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Camilla Gustafsen (Aarhus University, Denmark) "Role for Mosaic Receptor SorLA/LR11 in Regulation of Extra-Hepatic PCSK9 Activity" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Sarah Neuman (University of Wisconsin-Madison, USA) "A Screen for Systemic Growth Regulators Reveals Hobbit, a Novel and Conserved Regulator of Insulin Secretion" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | General Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inter-Organelle Communication |
| Discussion Leader: Kristi Wharton (Brown University, USA) |
7:30 pm - 7:55 pm | Loydie Jerome-Majewska (McGill University, Canada) "Protein Transport by TMED2 Is Required for Liver Homeostasis" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Rajini Rao (Johns Hopkins University School of Medicine, USA) "Endosomal NHE: Linking Luminal pH to Cargo Fate in Neurological Disorders" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Gary Thomas (University of Pittsburgh, USA) "Endosome Trafficking Meets the Nuclear Transcriptional Machinery" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Julia Von Blume (Max Planck Institute of Biochemistry, Germany) "Cargo Sorting During Protein Secretion" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Takes on Dense Core Vesicles |
| Discussion Leader: Alan Attie (University of Wisconsin-Madison, USA) |
9:00 am - 9:25 am | Michele Solimena (Universität Dresden, Germany) "Insulin Granule Aging and
Rejuvenation" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Adam Linstedt (Carnegie Mellon University, USA) "Targeting
Golgi Processing for Novel Therapeutics" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Betty Eipper (University of Connecticut Health Center, USA) "Biosynthetic and Endocytic
Roles for PAM" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Heather Brohier (Case Western Reserve University, USA) "Linking DCV Exocytosis to Synapse Formation" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Naushad Moti (Duke-NUS Graduate Medical School, Singapore) "Site of Action of Wntless Revealed by Live Cell Imaging of Wnt Secretion" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Xingmin Zhang (University of Wisconsin-Madison, USA) "BAIAP3, a C2 Domain-Containing Munc13 Protein, Regulates Endosome Recycling to the Golgi and Affects the Early Secretory Pathway" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Antonio Santos (Centre for Genomic Regulation (CRG), Spain) "The Novel Chimeric Protein Mia2/cTAGE5 Loads Pre-Chylomicrons/VLDLs at Endoplasmic Reticulum Exit Sites for Their Export" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Processing Enzymes in the Secretory and Endocytic Pathways |
| Discussion Leader: Lloyd Fricker (Albert Einstein College of Medicine, USA) |
7:30 pm - 7:55 pm | Galia Blum (Hebrew University of Jerusalem, Israel) "Where Do Proteases Function During Stress?" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | John Creemers (KU Leuven, Belgium) "The Role of PREPL in Regulated Secretion" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Klaudia Brix (Jacobs University Bremen, Germany) "Interactions Between Cysteine Cathepsins and GPCRs in Thyroid Hormone Mediated Endocrine Regulation" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Michael Ailion (University of Washington, USA) "The EARP Complex Controls Cargo Sorting to Dense-Core-Vesicles" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Feeding into Autophagosomes and Lysosomes |
| Discussion Leader: Indira Mysorekar (Washington University School of Medicine, USA) |
9:00 am - 9:25 am | Sharon Tooze (Francis Crick Institute, United Kingdom) "Molecular Pathways and Vesicular Traffic During Autophagosome Formation" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Roberto Zoncu (University of California, Berkeley, USA) "The Lysosome in Nutrient Sensing and Cellular Growth Control" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Ana Maria Cuervo (Albert Einstein College of Medicine, USA) "Chaperone-Mediated Autophagy: Crossing the Lysosomal Membrane Becomes Challenging in Neurodegeneration" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Jason Mills (Washington University School of Medicine in St. Louis, USA) "Mist 1: A Single Transcription Factor that Is Necessary/Sufficient to Block Autophagy and Build a Secretory Cell" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Cristina Mazuski (Washington University in St. Louis, USA) "Decoding the Firing Patterns of SCN VIP Neurons" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Stephanie Duval (Institut de Recherche Clinique de Montreal (IRCM), Université de Montréal, Canada) "Defining the Functions of the Type II-Transmembrane Proteins GPP130 and casc4: Shedding at Common and Distinct Sites by PC7 and Furin" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Gholson Lyon (Cold Spring Harbor Laboratory, USA) "The X-Linked Ogden Syndrome Involving NAA10 and the Amino-Terminal Acetylation of Proteins in Human Biology and Disease" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | To Image Trafficking and Secretion |
| Discussion Leader: Ronald Holz (University of Michigan Medical School, USA) |
7:30 pm - 7:55 pm | Edwin Levitan (University of Pittsburgh, USA) "Presynaptic Dense-Core Vesicle Traffic: Effects of Neuron Type, Activity and Injury" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Matthijs Verhage (Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands) "Trafficking and Fusion of Dense Core Vesicles in Mammalian Neurons" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Patrik Verstreken (VIB, KU Leuven, Belgium) "Sleep Defects in Parkinson's Disease" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Edwin Chapman (Howard Hughes Medical Institute / University of Wisconsin-Madison, USA) "Ca2+ Sensors that Regulate the Release of Hormones from the Anterior Pituitary" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |