Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
New Takes on Transport Along the Secretory Pathway
Discussion Leader: Betty Eipper (University of Connecticut Health Center, USA)
7:40 pm - 8:05 pm
Benjamin Glick (University of Chicago, USA)
"Kinetic Mapping of the Secretory Pathway"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Spencer Freeman (The Hospital for Sick Children, Canada)
"Cytoskeletal Fences and Transmembrane Pickets: Diffusional Barriers at the Plasma Membrane"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Alan Attie (University of Wisconsin-Madison, USA)
"The Genetic Architecture of Insulin Secretion"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Stephen Ireland (The University of Michigan, USA)
"Cellular Calcium Stress Induces Golgi Fragmentation Through PKCa Activation"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endocytic Pathway Trafficking and Connections to the Secretory Pathway
Discussion Leaders: Julia Von Blume (Max Planck Institute of Biochemistry, Germany) and Paul Taghert (Washington University in St. Louis, USA)
9:00 am - 9:25 am
Juan Bonifacino (National Institute of Child Health and Human Development, NIH, USA)
"Sorting of Endolysosomal Proteins at the Golgi Complex"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Judith Klumperman (University Medical Center Utrecht, The Netherlands)
"Multiple Roles of CORVET and HOPS Tethering Proteins in Membrane Trafficking"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Stephanie Duval (Institut de Recherches Cliniques de Montréal (IRCM), Université de Montréal, Canada)
"GPP130 and CASC4 Are Novel Substrates of PC7 and Furin: Investigating Their Roles in Cancer Progression"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
Selected from Poster Abstracts: Clive Wilson (University of Oxford, United Kingdom)
"Dense-Core Granule Biogenesis in Drosophila Secondary Cells Requires Cross-Talk Between the Secretory and Endosomal Pathways and a Rab6 to Rab11 Transition"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Yanzhuang Wang (University of Michigan, USA)
"Golgi Response to Cellular Stress"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Daniel Constam (École Polytechnique Fédérale de Lausanne, Switzerland)
"Live Imaging of Proprotein Convertase Activities at Subcellular Resolution"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Iris Lindberg (University of Maryland School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Updates on Processing (and Beyond) in the Secretory and Endocytic Pathways
Discussion Leader: Richard Mains (University of Connecticut Health Center, USA)
7:30 pm - 7:55 pm
Iris Lindberg (University of Maryland School of Medicine, USA)
"PCSK1 and proSAAS in Human Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Eleanor Raffan (University of Cambridge, United Kingdom)
"Lessons on the Role of POMC Derived Peptides in Obesity from Man's Best Friend"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Nabil G. Seidah (Institut de Recherches Cliniques de Montréal (IRCM), Canada)
"The Non-Enzymatic Functions of the Proprotein Convertases: PCSK9 and PCSK7 and Their Relationship to Dyslipidemia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Jonathan Sweedler (University of Illinois at Urbana-Champaign, USA)
"D-Amino Acid Containing Neuropeptides"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Treatment Mechanisms Targeting Diabetes, Obesity, Metabolic Syndrome et al .
Discussion Leader: John Creemers (KU Leuven, Belgium)
9:00 am - 9:25 am
Melanie Cobb (University of Texas Southwestern Medical Center, USA)
"Amplifying Insulin Secretion in β-Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Daniel Kirchhofer (Genentech, Inc., USA)
"Discovery of a Cryptic Peptide Binding Site on PCSK9 and Design of Antagonists"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Bruce Verchere (University of British Columbia, Canada)
"Beta Cell Loss of Prohormone Convertase 1/3 or Carboxypeptidase E Does Not Impair Glycemic Control"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Cedric Asensio (University of Denver, USA)
"Domains Responsible for trans -Golgi Network Targeting of the Peripheral Membrane Protein HID-1"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:25 am
Timo Müller (Institute for Diabetes and Obesity, Helmholtz Zentrum München, Germany)
"Novel Unimolecular Multiagonists for the Treatment of Obesity and Diabetes"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Irit Sagi (Weizmann Institute of Science, Israel)
"Targeting Pancreatic Cancer by Conformational Selective Anti-MMP7 Inhibitory Antibody"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
Natalie Borg (Monash University, Australia)
"Dissecting DDX3X Nuclear Export to Unlock Novel Anti-Viral Therapeutic Approaches"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Significance of Intra-Membrane Proteolysis and Proteolytic Events at the Cell Surface
Discussion Leader: Stefan Rose-John (University of Kiel, Germany)
7:30 pm - 7:55 pm
Sinisa Urban (Johns Hopkins University School of Medicine, USA)
"A Single-Molecule View of Rhomboid Protease Function Inside the Cell Membrane"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Carl Blobel (Hospital for Special Surgery, Weill Cornell Medicine, USA)
"iRhoms: Key Regulators of ADAM17-Dependent TNF and EGFR Signaling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Bernd Schroder (TU Dresden, Germany)
"The Intramembrane Protease SPPL2c Is Critical for Male Germ Cell Development by Processing Selected Tail-Anchored Proteins"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Selected from Poster Abstracts: Hung-En Hsia (German Center for Neurodegenerative Diseases (DZNE), Germany)
"Substrates and Functions of ADAM10 in the Mammalian Nervous System"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Sumeda Nandadasa (Lerner Research Institute, Cleveland Clinic, USA)
"The Secreted Metalloproteases ADAMTS9 and ADAMTS20 Have a Dual Role in Ciliogenesis and Extracellular Matrix Proteolysis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Processing in Development, Reproduction and Ageing
Discussion Leaders: Lloyd Fricker (Albert Einstein College of Medicine, USA) and Nicolas Calo (University of Wisconsin-Madison, USA)
9:00 am - 9:25 am
James Whisstock (Monash University, Australia)
"Control of Proteolysis in Drosophila Terminal Patterning"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Jan Christian (University of Utah, USA)
"Regulation of BMP Homo- and Heterodimer Activity by Prodomains and Interactions with the ECM"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Margarete M.S. Heck (University of Edinburgh, United Kingdom)
"Can the Sex Life of Drosophila Tell Us Anything About the Processing of Invadolysin?"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Gary Thomas (University of Pittsburgh, USA)
"Mitonuclear Communication in Response to Nutrient Stress"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Annemiek van Berkel (VU University Medical Center, The Netherlands)
"An Independent Role of the Exocytic SNARE Complex Proteins Munc18-1, SNAP25 and Syntaxin-1 in Neuronal Viability"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Ilaria Coppola (KU Leuven, Belgium)
"The Role of Furin in Obesity and Type 2 Diabetes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Secretory Proteases and Inhibitors in Health and Disease
Discussion Leader: Robert Fuller (University of Michigan Medical School, USA)
7:30 pm - 7:55 pm
Stefan Rose-John (University of Kiel, Germany)
"The Protease ADAM17 Drives Inflammation and Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Judith Clements (Queensland University of Technology, Australia)
"KLK Peptidases as Secreted Mediators of Invasive Processes in Prostate and Ovarian Cancer"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Bonnie Sloane (Wayne State University, USA)
"An Inside-out Role for Cathepsin B in Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Susanne Back (National Institute on Drug Abuse, NIH, USA)
"The KDEL Receptors Regulate Secretion of Endoplasmic Reticulum Resident Proteins Under Endoplasmic Reticulum Stress"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Lakshmi Devi (Icahn School of Medicine at Mount Sinai, USA)
"Neuropeptide Processing Proteases in Health and Disease: A Role for Endothelin Converting Enzyme in Modulating Pain"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Challenges in Protein Processing and Secretion
Discussion Leader: Nabil G. Seidah (Institut de Recherches Cliniques de Montréal (IRCM), Canada)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Ashley Buckle (Monash University, Australia)
"The Marriage of Experiment and Theory in Investigating the Molecular Mechanisms of Action of Proteases and Their Inhibitors"
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
Amantha Thathiah (University of Pittsburgh School of Medicine, USA)
"GPR3 and Novel GPCR Signaling in Alzheimer's Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
Selected from Poster Abstracts: John Chorba (University of California, San Francisco, USA)
"Cell-Associated, Heparin-Like Molecules Modulate the Ability of LDL to Regulate PCSK9 Uptake"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
Ronald Holz (University of Michigan Medical School, USA)
"Chromogranin A, the Major Lumenal Protein in Chromaffin Granules, Controls Fusion Pore Expansion and Its Expression in Granules Is Regulated"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Jerome Cattin (University of Washington, USA)
"The Conserved Coiled-Coil Protein CCCP1 and the Endosomal Complex EARP Regulate Dense-Core Vesicle Cargo Sorting"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Selected from Poster Abstracts: Ming Li (University of Michigan, USA)
"Sorting of a Multi-Subunit Ubiquitin Ligase Complex in the Endolysosome System"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Selected from Poster Abstracts: Robert Fuller (University of Michigan Medical School, USA)
"Modular Lipid Binding by Yeast Vps13p Can Promote Apposition of Bilayers with Distinct Lipid Compositions"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion: Therapeutic Options and Outcome Studies: From Cell Biology and Genetics to Future Perspectives
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms and Approaches in Protein Processing and Sorting in Signaling
Discussion Leader: Matthijs Verhage (CNCR, The Netherlands)
7:30 pm - 7:55 pm
Christopher Overall (University of British Columbia, Canada)
"Development of a nM Molecular Corrector Specifically Rescuing MALT1 Activity in NFkB Signalling in Immunodeficency"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Paul Taghert (Washington University in St. Louis, USA)
"Regulation of Prolonged GPCR Signaling that Creates Sequential Neuronal Activation Within Circadian Pacemaker Circuit"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Selected from Poster Abstracts: Julia Von Blume (Max Planck Institute of Biochemistry, Germany)
"Sphingolipid Metabolism Impinges on Calcium-Dependent Sorting of Secretory Cargo in the trans -Golgi Network"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Selected from Poster Abstracts: Yusong Guo (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Analysis of Protein Sorting at the trans -Golgi Network Through STORM Super-Resolution Imaging"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Selected from Poster Abstracts: Arun Anantharam (University of Michigan, USA)
"Multifaceted Regulation of Exocytosis by Synaptotagmin-7"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure