Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Protein Folding in the Secretory Pathway
Discussion Leader: Feyza Engin (University of Wisconsin-Madison, United States)
7:40 pm - 8:00 pm
Mondira Kundu (St. Jude Children's Research Hospital, United States)
"Autophagy and Secretion"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Francescopaolo Iavarone (TIGEM - Telethon Institute of Genetics and Medicine TELETHON, Italy)
"Selective ER-Phagy"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Feroz Papa (UCSF, United States)
"Targeting the Terminal UPR Using Next-Generation Small Molecule Kinase Inhibitors"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Feyza Engin (University of Wisconsin-Madison, United States)
"Targeting the Unfolded Protein Response as Therapy for Type 1 Diabetes"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycosylation and Phosphorylation in the Secretory Pathway
Discussion Leader: Melkam Kebede (The University of Sydney, Australia)
9:00 am - 9:25 am
Hudson Freeze (SanfordBurnhamPrebys MDI, United States)
"Protein Trafficking and Secretion in Congenital Disorders of Glycosylation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Heather Flanagan-Steet (Greenwood Genetic Center, United States)
"Glycan-Mediated Effects on Protein Processing in Development and Disease"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sara Bilekova (Helmholtz Munich, Germany)
"Inceptor Sorts Early Secretory Cargo in Pancreatic Beta Cells, Spermatocytes, and Lungs"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Iris Lindberg (University of Maryland School of Medicine, United States)
"The proSAAS Chaperone Self-Assembles into Liquid-Like Spheres Within the Secretory Pathway and Cytosol"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Kelly Ten Hagen (National Institutes of Health, United States)
"The Sweet Side of Secretory Granule Morphology and Secretion"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Michael Boyce (Duke University School of Medicine, United States)
"Intracellular Glycosylation in Protein Trafficking"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Julia von Blume (Yale University, United States) and Iris Lindberg (University of Maryland School of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nutrient Sensing, Ion Channels and Vesicle Trafficking
Discussion Leader: Peter Arvan (University of Michigan Medical School, United States)
7:30 pm - 7:55 pm
Matthew Merrins (University of Wisconsin-Madison, United States)
"Pyruvate Kinase Interactions with KATP Channels in the Regulation of Insulin Secretion"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Debbie Thurmond (City of Hope, United States)
"Newly Identified Roles for Old Vesicle Trafficking Proteins"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Samuel Stephens (University of Iowa, United States)
"Metabolic Regulation of Proinsulin Trafficking"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Melkam Kebede (The University of Sydney, Australia)
"The Role of Cab45 in Insulin Secretion"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Aggregation, Proteostasis and Autophagy
Discussion Leader: Regina Fluhrer (University of Augsburg, Germany)
9:00 am - 9:25 am
Jason Gestwicki (University of California, San Francisco, United States)
"Chemical Biology Approaches to Understand Protein Quality Control by Molecular Chaperones"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Randolph Hampton (University of California, San Diego, United States)
"Mallostery: Leveraging Proteostatic Specificity for Metabolic Regulation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Varsha Venkatarangan (University of Michigan, United States)
"Elucidating the Role of ERAD in Cystinosis Pathogenesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:55 am
Luigi Puglielli (University of Wisconsin-Madison, United States)
"Ne-lysine Acetylation and Proteostasis Within the Secretory Pathway"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
Judith Frydman (Stanford University, United States)
"Protein Folding and Proteostasis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Thomas Wollert (Institut Pasteur Paris, France)
"Membrane Remodeling by ATG16L1 Promotes Phagophore Expansion in Nonselective Autophagy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipid Transport Through the Secretory Pathway
Discussion Leader: Michele Solimena (TU Dresden, Germany)
7:30 pm - 7:55 pm
Anant Menon (Weill Cornell Medicine, United States)
"How Lipids Enter Mitochondria"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Russell Debose-Boyd (University of Texas Southwestern Medical Center, United States)
"Control of Cholesterol Synthesis Through Combined Action of ER-to-Golgi and ER-associated Degradation Pathways"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Thomas Melia (Yale University, United States)
"Lipid Trafficking in Autophagosome Biogenesis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Richa Sardana (Cornell University, United States)
"New Players Essential for Recycling Golgi Glycosyltransferases"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Maryalice Hartley (IUPUI, United States)
"SERCA2 Regulates ER Lipid Composition and Proinsulin Processing"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Visualizing the Secretory Pathway
Discussion Leader: Julia von Blume (Yale University, United States)
9:00 am - 9:25 am
Ana Paula Arruda (UC Berkeley , United States)
"The Role of Endoplasmic Reticulum Architectural Organization in Metabolic Health and Disease"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Anjon Audhya (University of Wisconsin-Madison, United States)
"Involvement of the Early Secretory Pathway in Neurodegenerative Disease"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Mathieu Ferron (Institut de Recherches Cliniques de Montreal (IRCM), Canada)
"Vitamin K-Dependent Carboxylation of Junctate Modulates Calcium Flux and Adaptation to Metabolic Stress in Beta-Cells"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Michele Solimena (TU Dresden, Germany)
"4D Imaging of the Secretory Granules"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Joerg Bewersdorf (Yale University, United States)
"Investigating Structures of the Secretory Pathway by Super-Resolution Microscopy"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Maohan Su (Yale School of Medicine, United States)
"Digital Organization of Golgi Apparatus"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
COVID-19 Entry Into the Cell and Assembly in the Secretory Pathway
Discussion Leader: Julia von Blume (Yale University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Gary Whittaker (Cornell University, United States)
"Coronavirus Spike Proteins and Entry into the Cell: Membrane Fusion Activation via Proteases and Other Host Factors"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Nihal Altan-Bonnet (National Institutes of Health, United States)
"COVID Egress Through a Lysosomal Pathway"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Hector Aguilar-Carreno (Cornell University, United States)
"Emerging Deadly Viruses and Their Glycoproteins – From Viral Entry to Vaccines and Antivirals"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Yanzhuang Wang (University of Michigan, United States)
"SARS-CoV-2 triggers Golgi Fragmentation via Down-Regulation of GRASP55 to Facilitate Viral Trafficking"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Proteolysis in the Secretory Pathway
Discussion Leader: Nabil Seidah (IRCM, Canada)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:25 am - 9:50 am
Thomas Delong (University of Colorado Anschutz Medical Campus, United States)
"Hybrid Insulin Peptides in Type 1 Diabetes: Mechanisms of Generation in Insulin Secretory Granules"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
Annik PRAT (IRCM (Montreal), Canada)
"PCSK9 Deficiency Results in a Specific Shedding of Excess LDLR in Female Mice Only: Role of Hepatic Cholesterol"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Regina Fluhrer (University of Augsburg, Germany)
"Role of SPP/SPPL Proteases in Protein Trafficking and Metabolism"
11:20 am - 11:25 am
Discussion
11:25 am - 11:50 am
Stefan Lichtenthaler (German Center for Neurodegenerative Diseases (DZNE), Germany)
"Trafficking and Processing of Membrane Protein Substrates of the Alzheimer Protease BACE1"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Rosaria Di Martino (Institute for Endocrinology and Experimental Oncology (IEOS-CNR) Napoli, Italy, Italy)
"Autoregulatory Circuit Regulating Basolateral Cargo Export From the TGN"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:40 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exosomes
Discussion Leader: Anjon Audhya (University of Wisconsin-Madison, United States)
7:30 pm - 7:55 pm
Carmella Evans-Molina (Indiana University School of Medicine, United States)
"β Cell-Derived Exosomes: A Window to the Soul of a Cell?"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Wei Guo (University of Pennsylvania, United States)
"Exosomes and Regulation of Immunity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Anup Parchure (Yale school of Medicine, United States)
"Liquid-Liquid Phase Separation Facilitates Insulin Delivery to the Secretory Storage Granule"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Late-Breaking Topic
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure