| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session |
| Discussion Leader: Mathilde Bonnemaison (UCHC) |
| 3:45 pm - 4:15 pm | Gary Thomas (University of Pittsburgh School of Medicine)
"Leveraging Proteases: From Anthrax Activation to Cell Cycle Regulation"
|
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Protein Processing, Trafficking and Secretion |
| Discussion Leader: Carolyn Fisher (Cornell University) |
| 7:30 pm - 7:46 pm | Carolyn Fisher (Cornell University)
"Investigating the Role of Cis/Trans Peptidyl-Prolyl Isomers in Signal Transduction"
|
| 7:46 pm - 7:54 pm | Discussion |
| 7:54 pm - 8:10 pm | Magdalena Schacherl (University of Cologne)
"Camelid Nanobody Driven Stabilization of an Archaeal Site-2 Protease - A Systematic Study Leading Toward the Full-Length Crystal Structure"
|
| 8:10 pm - 8:18 pm | Discussion |
| 8:18 pm - 8:34 pm | Anna Jansen (University of Copenhagen)
"The BAR Domain Protein PICK1 Controls Vesicle Number and Size in Adrenal Chromaffin Cells"
|
| 8:34 pm - 8:42 pm | Discussion |
| 8:42 pm - 8:58 pm | Monique Rogals (Cornell University)
"Elucidating the Interaction Between the Substrate Binding Domain of Human Heat Shock 70 kDa Protein (Hsp70) and the Cytosolic Tail of Amyloid Precursor Protein (APPc)"
|
| 8:58 pm - 9:06 pm | Discussion |
| 9:06 pm - 9:22 pm | Ben Moore (Washington University in St. Louis)
"The Novel Transcriptional Regulation of XBP1 by HNF4a Underlies Mature-Onset Diabetes of the Youth 1 Pathology"
|
| 9:22 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Proprotein Convertases in Homeostasis and Pathologies |
| Discussion Leader: Bas Brouwers (KU Leuven) |
| 9:00 am - 9:16 am | Bas Brouwers (KU Leuven)
"Impaired Islet Function in Commonly Used Transgenic Mouse Lines Due to Human Growth Hormone Minigene Expression"
|
| 9:16 am - 9:24 am | Discussion |
| 9:24 am - 9:40 am | Camilla Gustafsen (Aarhus University, Denmark)
"Sortilin Facilitates Secretion of PCSK9 by Sorting from the Trans-Golgi Network"
|
| 9:40 am - 9:48 am | Discussion |
| 9:48 am - 10:04 am | Frederic Couture (Université de Sherbrooke)
"Novel Prostate Cancer-Specific Alternative Splicing Form of PACE4"
|
| 10:04 am - 10:12 am | Discussion |
| 10:12 am - 10:28 am | Elias Blanco (University of Maryland)
"Human PC1/3 Ser357Gly: A Mutant with PC2-Like Activity"
|
| 10:28 am - 10:36 am | Discussion |
| 10:36 am - 10:52 am | Fabienne Soulet (INSERM, University of Bordeaux)
"Importance of Apelin Processing by Furin-Like Enzymes in Angiogenesis and Tumorigenesis"
|
| 10:52 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Development |
| Discussion Leader: Jeroen Declercq (KU Leuven) |
| Panelists:
- John Creemers (KU Leuven)
- Hans-Ulrich Demuth (Fraunhofer-Institute Leipzig)
- Paul Taghert (Washington University Medical)
- Bette Phimister (Deputy Editor, NEJM)
- Ken Pearce (GSK)
- Peter Lyons (Teacher/Researcher, Andrews University)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
