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Proteoglycans

Gordon Research Conference

July 9 - 14, 2000
Chair Renato V. Iozzo
Vice Chairs Arthur Lander
Proctor Academy
204 Main Street
Andover, New Hampshire, United States
 Venue and Travel Information

Conference Program

Sunday, July 9, 2000
Session 1: (7:30-9:45 p.m.)		Emerging Model Systems in Proteoglycan Research
Discussion Leaders: Jeffrey Esko and Ulf Lindhal
  • Norbert Perrimon: Drosophila tout velu (EXT) gene in hedgehog signaling
  • Joshua Rubin: Heparan sulphate proteoglycans modulate Sonic hedgehog-induced proliferation of cerebellar granule cells
  • Scott Saunders: Glypican-3 controls cellular responses to BMP4 in limb patterning and skeletal development
  • Donald Moerman: Complex pattern of alternatively splicing of perlecan in C. Elegans
  • Mauro Pavao: Occurence of heparin in the invertebrate Styela Plicata (Tunicata) is restricted to cell layers facing the outside environment: an ancient role in defense?
Monday, July 10, 2000
Session 2: (9:00-12:30 a.m.)		Proteoglycan Biosynthesis and Assembly
Discussion Leaders: Lena Kjellén and Koji Kimata
  • Nick Shworak: Heparan sulfate: structure in search of biology - biology in search of structure
  • Carlos Hirschberg/Patricia Berninsone: Novel regulation of glyconjugate biosynthesis
  • Peter H. Seeberger: A general, highly convergent, and modular synthesis of heparin-like glycosaminoglycan oligosaccharides
  • Kay Grobe: Molecular properties of the four members of teh heparan sulfate/heparin GlcNAc N-deacetylase/M-sulfotransferase family
  • Osami Habuchi: Molecular cloning and characterization of chondroitin 4-sulfotransferase
  • Kazuyuki Sugahara: The biosynthesis of the glycosaminoglycan-protein linkage region
  • Sally Stringer: Heparin in the brain
  • Scott Guimond: Dynamic expression of heparan sulfate biosynthetic enzymes in developing mouse brain
  • Hans Kresse: Influence of core protein on glycosaminoglycan chain attachment and glucuronic acid epimerization in chondroitin/dermatan sulfate proteoglycans
Monday, July 10, 2000
Session 3: (7:30-9:45 p.m.)		Heparin and Heparan Sulfate in Cell Biology and Development
Discussion Leaders: Rick Stevens and John Hassell
  • Erik Forsberg: N-deacetylase/N-sulfotransferase-1 knockout
  • Donald Humphreis: Generation of N-deacetylase/N-sulfotransferase-2-null mice to elucidate the function of heparin
  • Kevin Williams: A novel role for the heparan sulfate N-deaccetylase/M-sulfotransferase-1 in diabetic complications
  • Charles Emerson: Identification of a novel extracellular N-acetylglucosamine 6-sulfatase required for myoD activation in avian somites
  • Maria Pinhal: Infrastructure of teh enzymes involved in heparan sulfate biosynthesis
  • Yoshi Yamada: Role of perlecan in mammalian development
Tuesday, July 11, 2000
Session 4: ( 9:00-12:30 a.m.)		The Biology of Hyaluronan and Its Receptors
Discussion Leaders: Brian Toole and Cheryl Knudson
  • Paul Noble: CD44-/- mice have altered hyaluronan turnover and persistent inflammation following lung injury
  • Raja Tammi: Role of CD44 in the catabolism of hyaluronan in keratinocytes
  • Paul H. Weigel: Identification of HARE, the hyaluronian receptor for endocytosis
  • Anthony J. Day: Determination of the hyaluronian binding site on human TSG-6
  • Carol de la Motte: The role of hyaluronan in inflammatory bowel disease
  • Ivan Stamenkovic: Mechanisms of CD44-mediated tumor invasion and angiogenesis
  • Paul L. DeAngelis: Two active sites exist in the Pasteurella multocida hyaluronian synthase
Tuesday, July 11, 2000
Session 5: (7:30-9:45 p.m.)		Protein-Glycosaminoglycan Interactions
Discussion Leaders: Anna Plaas and John Gallagher
  • Robert Linhardt: Overview of heparin/protein interactions
  • David Stuart: Structural basis of heparan sulfate/virus interactions
  • Ganesh Venkataraman: Specific conformational changes in heparin/heparan sulfate-like glycosaminoglycans resulting in a "kink" when bound to proteins
  • Toin van Kuppevelt: Phage display derived antibodies to heparan sulfate: new tools for studying proteoglycans
  • Jim San Antonio: Design of peptides with high affinities for heparin and endothelial cell proteoglycans
  • Catherine Merry: Analysis of the altered structure and growth factor binding properties of heparan sulfate chains from mice homozygous for a gene trap mutation in the gene encoding HS 2-O-sulfotransferase
Wednesday, July 12, 2000
Session 6: (9:00-12:30 a.m.)		Proteoglycan/Growth Factor Interactions and Signaling
Discussion Leaders: Anne Woods and Paul Goetinck
  • Eva Turley: Hyaluronan receptors and cell signaling
  • John McDonald: A hyaluronan-dependent signaling mechanism involving Ras activation
  • Maryse Delehedde: Regulation by heparan sulfate of signaling by FGF2 and HGF in mammary cells
  • Malcolm Lyon: The specificity and role of proteoglycans in the regulation of hepatocyte growth factor
  • Matthew Nugent: Heparan sulfate proteoglycans control FGF transport and intracellular processing
  • John Couchman: Oligomerization and signaling through syndecan-4
  • John Lincecum: Conservation of function in syndecans: Drosophila syndecan and murine syndecan-1 cytoplasmic domains are required for changes in epithelial morphology
  • Ralph D. Sanderson: The ectodomain core protein of syndecan-1 participates in generating signals that promote cell spreading
Wednesday, July 12, 2000
Session 7: (7:30-9:45 p.m.)		The Biology of Small Leucine-Rich Proteoglycans
Discussion Leaders: Marian Young and Shukti Chakravarti
  • David McQuillan: Structural requirements for functional small leucine-rich proteoglycans
  • Elke Schoenherr: Decorin as a mediator of angiogenesis
  • Lari Hakkinen: A role for decorin in the structural organization of periodontal ligaments
  • Paul N. Bishop: Opticin, a new member of the small leucine-rich proteoglycan gene family
  • Justin Fallon: The role of biglycan in MuSK signaling and muscular dystrophy
  • Winston Kao: Overexpression of buglycan induces ocular surface disorders in Ktcnpr-BGLN transgenic mice
Thursday, July 13, 2000
Session 8: (9:00-12:30 a.m.)		Proteoglycans in Disease States
Discussion Leaders: Bruce Caterson and Amanda Fosang
  • Tom Wight: Cell-mediated proteoglycan gene transfer alters the development of vascular lesions
  • Jan Borén: Proteoglycan- binding defective LDL in the initiation of atherosclerosis
  • Steven D. Rosen: Endoglycan, a novel sialomucin/proteoglycan on endothelial cells
  • Bryan P. Toole: Hyaluronan oligosaccharides and soluble CD44 inhibit anchorage-independent growth of tumor cells
  • Murray Korc: The role of glypican in the pathobiology of cancer
  • Frank Tufaro: EXT genes in hereditary bone tumors
  • Roberto Perris: Versican in tumor progression and neoangiogenesis
  • Anna Bassols: Versican expression in human melanoma
Thursday, July 13, 2000
Session 9: (7:30-9:45 p. m.)		Microbial Interactions and Therapeutics
Discussion Leader: Magnus Höök and Vincent Hascall
  • Pat Spear: Herpes simplex virus/heparan sulfate interactions
  • Glenn Prestwitch: Drug delivery in wound healing using hydrogel films
  • Michael Kinsella: Retrovirally-mediated overexpression of decorin in bovine aortic endothelial cells inhibits cell migration and increases fibrillar matrix assembly
  • Urs Rutishauser: Polysialic acid, transition from the fly to Albert Einstein

Contributors

We are deeply grateful to the following agencies for their generous support:

AMGEN, INC
ELI LILLY & COMPANY
GENENTECH, INC.
GENZYME CORPORATION
GLYCOFORUM-SEIKAGAKU CORPORATION
GORDON RESEARCH CONFERENCES
MERCK RESEARCH LABORATORIES
NEW ENGLAND BIOLABS, INC.
NATIONAL INSTITUTES OF HEALTH (NIAMS, NICHD, NCI)
ORQUEST, INC.
PFIZER, INC.
SHRINERS HOSPITALS FOR CHILDREN
SMITHKLINE BEECHAM PHARMACEUTICALS
THOMAS JEFFERSON UNIVERSITY

Conference Links

Conference History
Additional Fee Info

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