| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm |
LATE BREAKING RESULTS: FRONTIERS IN STRUCTURE/FUNCTION RELATIONSHIPS |
| Discussion Leader: Arthur D. Leader (University of California, Irvine) |
| Charles Emerson (University of Pennsylvania)
Enzymatic Modulation of the Sulfation States of Extracellular Heparan Sulfate
Proteoglycans |
| Stephen Cohen (EMBL, Heidelberg)
Notum: A Secreted Enzyme that may Modify Proteoglycans to Shape The Wg Morphogen Gradient |
| Sarah J. Goodger (Patterson Institute, Manchester, UK)
Heparan Sulphate In The Regulation Of Fgf-2 |
| Bradley Olwin (University of Colorado, Boulder)
Syndecans-3 and -4: Functional Markers for Skeletal Muscle Stem Cells |
| Bart De Cat (University of Leuven, Belgium)
The Apoptosis-inducing Activity of Glypican-3 depends on Processing by
Proprotein Convertases |
| 9:30 pm | Discussion/Reception at Posters |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | SYNTHESIS, BIOSYNTHESIS AND SEQUENCE
ANALYSIS |
| Discussion Leader: Lena Kjellen (Uppsala
University, Sweden) |
| Ram Sasisekharan (Massachusetts Institute of
Technology)
"HS Glycosaminoglycans: Sequence and Activity Relationships" |
| Ulf Lindahl (Uppsala University, Sweden)
"Sequence Analysis of Protein-binding Domains in Heparan Sulfate" |
| Jian Lu (University of North Carolina)
"Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin binding site and an entry receptor for herpes simplex virus-1" |
| Ganesh Venkataraman (MIT)
"Heaprin/heparan sulfate sequence database: foundation for H/HS bioinformatics" |
| Robert Rosenberg (Massachusetts Institute of
Technology, Harvard)
"New lessons learned from the antithrombin and the FGF receptor 1 systems" |
| Hiroshi Kitagawa (Kobe Pharmaceutical
University, Japan)
"Chondroitin Biosynthesis and Novel Function" |
| Maria Thuveson (Uppsala University)
"Effect of EXT1/EXT2 on NDST1 maturation" |
| Megumi Morimoto-Tomita (University if California, San Francisco)
"Cloning and characterization of two novel extracellular sulfatases in mouse and human" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm |
STRUCTURAL BIOLOGY AND BIOPHYSICS OF PROTEOGLYCANS
AND THEIR INTERACTIONS |
| Discussion Leader: John Gallagher, (Patterson
Institute for Cancer Research, UK) |
| Christine Ortiz (Massachusetts Institute of
Technology)
"Nanomechanics of Cartilage: Direct Measurement of Glycosaminoglycan
Intermolecular Interactions Via High-Resolution Force
Spectroscopy" |
| Anthony Day (Oxford University)
"Hyaluronan-Protein Interactions: Cooperativity and Fibril
Formation" |
| Joseph Zaia (Boston University)
"Tandem mass spectrometric sequencing of heparin and heparan sulfate oligosaccharides" |
| Patricia J. LiWang (Texas A&M University)
"Investigation of the GAG binding properties of teh anti-HIV chemokine Mip-1beta" |
| Gunnar Pejler (University of Uppsala)
"Modulation of Mast Cell Protease Activities by Heparin Proteoglycan" |
| Guido Jenniskens (MIT)
"A novel role for heparan sulfate in skeletal muscle calcium kinetics" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm |
CELL BIOLOGY OF PROTEOGLYCANS: REGULATION OF
CELLULAR SIGNALING |
| Discussion Leader: Alan Rapraeger (University
of Wisconsin-Madison) |
| David Fernig (University of Liverpool)
"Regulation of Cellular Responses by Growth Factor-GAG Interactions:
What do We Really Understand?" |
| Dina Ron (Israel Institute of Technology)
"Regulation of FGF Activities by HSPGs: Lessons Learned from
Studying HSPG Effects on FGF-1 and FGF-7 Activities" |
| Benjamin L. Allen (University of Wisconsin-Madison)
FGF Signaling is Governed by Distinct Heparan Sulfate Domains During
Mouse Development |
| Kazuyuki Sugahara (Kobe Pharmaceutical University, Japan)
Highly sulfated dermatan sulfate exhibits neurite outgrowth promoting activity
towards embryonic rat hippocampal neuronal cells |
| Rebecca Wells (Yale University)
"Betaglycan As A Modulator of TGF-beta Signaling" |
| Joshua Rubin (Harvard Medical School)
Direct Interactions Between Sonic Hedgehog and Heparan Sulfate
Proteoglycans Regulate Sonic Hedgehog Internalization and Downstream
Responses. |
| Scott Saunders (Washington University, St. Louis)
Heparan Sulfate Proteoglycans Retain Noggin at the Cell Surface: A Potential
Mechanism for Shaping BMP Gradients |
| Anil Karihaloo (Yale University)
Endostatin Requires Glypican Expression to Modulate Renal Epithelial Cell
Morphogenesis |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm |
CELL BIOLOGY OF PROTEOGLYCANS: ROLES IN THE
EXTRACELLULAR MATRIX |
| Discussion Leader: Shukti Chakravarti (John
Hopkins University) |
| Josephine Adams (Cleveland Clinic)
"Roles of Thrombospondins and Syndecan-1 in Building Fascin Spikes" |
| Koji Kimata (Aichi Medical University)
"Serum-Derived Hyalyronan Associated Protein (SHAP)-Hyaluronan
Interactions, and Their Physiological Roles" |
| James Funderburgh (University of Pittsburgh)
Genes for Corneal Dermatan Sulfate Biosynthesis and Modulation of their
Expression During Keratocyte-myofibroblast Transdifferentiation
|
| David Birk (Thomas Jefferson University)
"Proteoglycan-Collagen Interactions: Regulation of Fibrillogenesis
and Development of Extracellular Matrix Function" |
| Elke Schonherr (University of Muenster, Germany)
Small Proteoglycan Deficiency in Mouse Cornea: Changes in Fibrils and
Decorin-specific Reduction of Angiogenesis
|
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm |
PROTEOGLYCANS IN DEVELOPMENTAL
BIOLOGY |
| Discussion Leader: Scott Selleck (Arizona
Cancer Center) |
| Val Wilson (University of Edinburgh, UK)
"Developmental Roles of HS Modifying Enzymes in the Mouse" |
| Joseph Yost (University of Utah)
"Proteoglycan-Mediated Signal Modulation In Left-right Development" |
| Brett Crawford (University of California, San Diego)
The Role of GIcNAc N-Deacetylase N-Sulfotransferase 1 (NDST1) in
Mammary Development
|
| Liliana Solnica-Krezel (Vanderbilt University)
"The Role of Glypican Knypek in Cell Movements During Zebrafish
Gastrulation" |
| Jeroen Bakkers (Max Planck Institute for Immunobiology, Freiburg, Germany)
The Zebrafish Hyaluronan Synthase 2 (Has2) Homologue Dg4211 Is Required
For BMP-Mediated Cell Migration Towards The Embryonic Axis During
Gastrulation. |
| Giancarlo Ghiselli (Thomas Jefferson University)
D-Glucuronyl C5-Epimerase is Necessary for Dorsal-Ventral Patterning in
Zebrafish |
| Hiroshi Nakato (University of Arizona)
"Dally regulates the morphogen gradient formation of Decapentaplegic, a Drosophila TGF-beta" |
| Hannes Bulow (Columbia University)
Heparan sulfate side chain modifying enzymes have important roles in
neuronal development
|
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm |
PROTEOGLYCANS IN PHYSIOLOGY: NEURAL TISSUE,
CONNECTIVE TISSUE, AND CANCER |
| Discussion Leader: Anna Plaas (Shriners Hospital
for Children) |
| James Fawcett (University of Cambridge, UK)
"Proteoglycans in Neural Regeneration and Plasticity" |
| Jeffrey Loeb (Wayne State University)
"Transynaptic Gene Regulation Through Neuregulin-HSPG Interactions" |
| Jeremy Turnbull (University of Birmingham, UK)
Touching BACE: Heparan Sulfate Regulates R-Secretase Cleavage of the
Amyloid Precursor Protein
|
| Bryan Toole (Tufts University)
"Perturbation of Hyaluronan-Cell Interaction Inhibits Tumor Growth
Via Suppression of Cell Survival and Induction of Apoptosis"
|
| Andrew P. Spicer (Institute for Biosciences & Technology, Texas A&M Univ.)
The Missing Links: A Hyaluronan-Binding Link Protein Gene Family whose
Members are Physically Linked to the Core Protein Genes Encoding the Large
Aggregating Chondroitin Sulfate Proteoglycans |
| Andreas Friedl (University of Wisconsin-Madison)
Modulation of FGF Receptor Binding by Endothelial Cell Heparan Sulfate
Proteoglycans - Implications for Tumor Angiogenesis |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm |
PROTEOGLYCANS IN PHYSIOLOGY: CARDIOVASCULAR,
IMMUNE/INFLAMMATORY, AND REPRODUCTIVE SYSTEMS |
| Discussion Leader: Paul Goetinck (Harvard
University) |
| Pyong Park (Baylor College of Medicine)
“Syndecans as Regulators of Infectious and Non-infectious Tissue Injury” |
| Ariane De Agostini (University of Geneva)
"Heparan Sulfate Proteoglycans in Mammalian Reproductive Function" |
| Wei-hsuan Yu (Harvard Medical School)
CD44HSPG Trans-Activating ErbB4 Mediated By ProHB-EGF Proteolytic
Processing By MMP-7 During Female Reproductive Organ Remodeling |
| Robert Kokenyesi (Saint Louis University)
Deficiency In Lumican Causes Premature Cervical Softening In Pregnant Mice |
| Tim Wells (Serono Pharmaceutical Research
Institute)
"Chemokines and Glycosaminoglycans-Interesting Artefact, or
Physiological Control Mechanism" |
| Renato Iozzo (Jefferson Medical College)
"Novel Anti-Angiogenic Sequences Embedded In The Perlecan Protein
Core" |
| John McDonald (University of Utah)
Hyaluronan and the ErbB Family of Receptor Tryrosine Kinases are Required
for Epithelial-Mesenchymal Transformation During Cardiac Morphogenesis |
| Noel Carter (University of Sunderland, UK)
Differential Expression of The N-Deacytylase/N-Sulphotransferase (NDST)
Family: Modification of Glycosaminoglycan Composition and Function During
Inflammation |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm |
PROTEOGLYCANS IN THE CLINIC: DIAGNOSIS AND
THERAPY |
| Discussion Leader: Nicholas Shworak (Darmouth
Medical School) |
| Sheila Laverty (University of Montreal)
"Effects of Glucosamine on Articular Cartilage in an Experimental
Model of Osteoarthritis" |
| Thomas N. Wight (Hope Heart Institute, Seattle)
Use of Proteoglycan Genes for the Creation of Elastic Tissue Sheets and
Small Caliber Prosthetic Vessels |
| Leslie B. Gordon (Tufts Medical School, Boston)
The Role of Hyaluronan in Hutchinson-Gilford Progeria Syndrome |
| Lubor Borsig (University of Zurich)
"Heparin Inhibition of Selectin-Mediated Interactions Attenuates
Carcinoma Metastasis" |
| Mark Sands (Washington University, St. Louis)
"Gene Therapy for Mucopolysaccharidoses" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
