SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
5:00 pm - 6:00 pm | Wine and Cheese Reception |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome and Introductions (Alan C. Rapraeger, Conference Chair) |
7:45 pm - 9:30 pm | Late Breaking Developments in Proteoglycan Research |
| Discussion Leader: Alan C. Rapraeger (University of Wisconsin-Madison, USA) |
7:45 pm - 8:02 pm | Matthew P. Hoffman (National Institutes of Health, USA)
"Heparan sulfate regulation of FGF10 function during salivary gland branching morphogenesis" |
8:02 pm - 8:10 pm | Discussion |
8:10 pm - 8:27 pm | Hideto Watanabe (Aichi Medical University, Japan)
"Glycosyltransferase(s) critical for chondroitin sulfate biosynthesis in cartilage" |
8:27 pm - 8:35 pm | Discussion |
8:35 pm - 8:52 pm | Juan Larrain (Pontificia Universidad Católica de Chile, Chile)
"Proteoglycan function during early development of Xenopus embryos" |
8:52 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | DeannaLee Beauvais (University of Wisconsin-Madison, USA)
"Regulation of αvβ3 and αvβ5 integrins by syndecan-1 in angiogenesis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Suniti Misra (Medical University of South Carolina, USA)
"Regulation of Receptor Tyrosine kinases and COX-2 by Hyaluronan and its potential role in colon cancer" |
9:15 pm - 9:30 pm | Discussion |
9:30 pm | Reception at Posters |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Biosynthesis and Structure of Glycosaminoglycans |
| Discussion Leader: Barbara Mulloy (National Institute for Biological Standards and Control, UK) |
9:00 am - 9:20 am | Lena Kjellén (Uppsala University, Sweden)
"Cellular design of heparan sulfate" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Kazuyuki Sugahara (Kobe Pharmaceutical University, Japan)
"Functions and structural motifs of chondroitin sulfate/dermatan sulfate" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Jeremy Turnbull (Univ. Liverpool, UK)
"Exploitation of heparan sulfates in directed neuronal differentiation of stem cells" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | William Lamanna (Univ. Goettingen, Germany)
"mSulf1 and mSulf2 differentially modify heparan sulfate 6-O sulfation patterning" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Marco Maccarana (Lund University, Sweden)
"Dermatan sulfate epimerases" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Julie Leary (University of California-Davis, USA)
"Mapping GAG-Chemokine Interactions and Multimer Specificity" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | James Funderburgh (Univ. Pittsburgh, USA)
"Identification of enzymes involved in corneal keratan sulfate synthesis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Guido Jenniskens (Univ. Medical Center Nijmegen, Netherlands)
"Myo-glycomics: glycosaminoglycans in healthy and diseased muscle interstitium" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Softball Match |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structure-Activity of Glycosaminoglycans |
| Discussion Leader: Dina Ron (Technion, Israel) |
7:30 pm - 7:50 pm | John Gallagher (University of Manchester, UK)
"Design and Function in Heparan Sulfate" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Moosa Mohammadi (New York University, USA)
"A protein canyon in the FGF-FGFR dimer selects from an à la carte menu of heparan sulfate motifs" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Amanda Proudfoot (Serono Pharmaceutical Research Institute, Switzerland)
"The role of chemokine-proteoglycan interactions in chemokine biology" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Elliot Chaikof (Emory Univ., USA)
"Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Malcolm Lyon (Univ. Manchester, UK)
"The specificity of glycosaminoglycan interactions with hepatocyte growth factor / scatter factor (HGF/SF)" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Discussion at Posters |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Proteoglycans of the Musculoskeletal System |
| Discussion Leader: Renato Iozzo (Thomas Jefferson University, USA) |
9:00 am - 9:20 am | Marian Young (National Institutes of Health, USA)
"SLRPs in skeletal function and aging" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Lilliana Schaefer (University of Muenster, Germany)
"Decorin- and biglycan-signaling in inflammation and fibrosis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Jens W. Fischer (Univ. Dusseldorf, Germany)
"Biglycan is required for adaptive remodeling after myocardial infarction" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Stacey C. Schutte (Georgia Institute of Technology, USA)
"The effects of decorin on collagen synthesis and strength in blood vessel substitutes" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Enrique Brandan (Catholic University of Chile, Chile)
"Role of SLRPs during skeletal muscle formation and disease" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Winston Kao (University of Cincinnati, USA)
"Lumican in epithelial-mesenchymal transition and wound healing" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Shukti Chakravarti (John Hopkins Univ., USA)
"Extracellular matrix proteoglycan lumican promotes CD14-TLR4-mediated innate immune response to bacterial lipopolysacharide" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Kevin McCarthy (Louisiana State Univ., USA)
"Targeted deletion of EXT1 in glomerular podocytes leads to compromise of the ultrastructure of the glomerular capillary wall in mice" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Cricket Match |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Proteoglycans in Cell Signaling Mechanisms |
| Discussion Leader: Anne Woods (University of Alabama-Birmingham, USA) |
7:30 pm - 7:50 pm | Pascale Zimmermann (University of Leuven, Belgium)
"Intracellular mechanisms of syntenin/syndecan signaling" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Peisong Ma (Univ. Virginia, USA)
"Heparanase deglycanation of syndecan-1 is required for binding of epithelial-restricted prosecretory mitogen 'lacritin'" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Bradley Olwin (University of Colorado-Boulder, USA)
"Syndecan regulation of the muscle stem cell niche" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Eok-Soo Oh (Ewha Womans University, Korea)
"Syndecan-2 signaling activity in tumorigenesis" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Manoranjan M. Santra (Henry Ford Hospital, USA)
"Neuro protection by de novo decorin expression in an ischemic cell culture model system" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Discussion at Posters |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Proteoglycans in Development |
| Discussion Leader: Scott Selleck (University of Minnesota, USA) |
9:00 am - 9:20 am | Rahul Warrior (University of California-Irvine, USA)
"Developmental regulation of heparan sulfate proteoglycan synthesis in Drosophila" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Henry Roehl (University of Sheffield, UK)
"The role of HSPGs during zebrafish skeletal morphogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Simona Zisman-Rozen (Technion Institute of Technology, Israel)
"Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Keisuke Kamimura (Aichi Medical University, Japan)
"Specific and flexible roles of heparan sulfate modifications in drosophila FGF signaling" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Norman Rosenblum (Hospital for Sick Children, Canada)
"Modulation of signaling and morphogenesis in the kidney by HSPGs" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Sara Olson (University of California-San Diego, USA)
"A novel class of CSPGs mediate early embryogenesis in C. elegans" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Scott Saunders (Washington Univ., USA)
"Functional role of glypican-3 in hematopoiesis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Yasuhiro Katagiri (National Institutes of Health, USA)
"Quantitative differential sulfation pattern of chondroitin regulates axonal guidance" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Proteoglycans in Injury and Inflammation |
| Discussion Leader: Thomas Wight (Benaroya Research Institute, USA) |
7:30 pm - 7:50 pm | Burton Yang (Sunnybrook and Women's Health Science Center, Canada)
"The role of proteoglycan versican in mediating endothelial cell activities and angiogenesis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Paul Noble (Yale University, USA)
"Location matters: The role of Hyaluronan in lung injury and repair" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Anna Plaas (University of South Florida, USA)
"Proteoglycanolysis in the Arthritic Joint: Pro-and Anti-inflammatory Roles of ADAMTSs and MMPs" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:07 pm | Herbert Geller (National Institutes of Health, USA)
"Chondroitin sulfate proteoglycan glycosaminoglycan chain synthesis: a potential molecular target" |
9:07 pm - 9:10 pm | Discussion |
9:10 pm - 9:17 pm | Charles W. Frevert (Univ. Washington, USA)
"The role of MyD88 in regulating the expression of proteoglycans and hyaluronan synthases in lungs of mice exposed to lipopolysaccharide" |
9:17 pm - 9:20 pm | Discussion |
9:20 pm - 9:27 pm | Carol de La Motte (Cleveland Clinic Foundation, USA)
"Hyaluronan-mediated platelet-endothelial cell interactions specifically generate signaling-sized fragments of hyaluronan that promote inflammation and angiogenesis" |
9:27 pm - 9:30 pm | Discussion |
9:30 pm | Discussion at Posters |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Proteoglycans in Cancer |
| Discussion Leader: Ralph Sanderson (University of Alabama-Birmingham, USA) |
9:00 am - 9:20 am | Renato Iozzo (Thomas Jefferson Univ., USA)
"Processed forms of perlecan regulate tumor angiogenesis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Steven Rosen (University of California-San Francisco, USA)
"Hsulf in pancreatic cancer and wnt signaling" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Melanie Simpson (Univ. Nebraska, USA)
"Progression of prostate cancer is induced by hyaluronan synthesis and turnover" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Andreas Friedl (Univ. Wisconsin-Madison, USA)
"Glypican-1 is required for cell cycle progression in mouse brain endothelial cells" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Lena Claesson-Welch (Uppsala University, Sweden)
"Heparan sulfate in transactivation of growth factor receptors" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Hiroyuki Aburatani (University of Tokyo, Japan)
"Glypican-3 as a novel diagnostic and therapeutic target for hepatocellular carcinoma" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Qin Yu (Univ. Pennsylvania, USA)
"The pro- and anti-metastatic activity exerted by full-length ADAMTS-1 and the ADAMTS-1 fragments, respectively, is regulated by heparan sulfate proteoglycan" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Joji Iida (Univ. Minnesota, USA)
"Chondroitin sulfate enhances pro-MMP-2 (progelatinase A) activation by membrane-type 3 matrix metalloproteinase (MT3-MMP) in vitro" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time / Soccer Match |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 7:50 pm | Poster Awards |
| Leader: Tom Wight, Conference Vice-Chair |
7:50 pm - 9:30 pm | Proteoglycans in Disease Models |
| Discussion Leader: Shukti Chakravarti (Johns Hopkins University, USA) |
7:50 pm - 8:20 pm | Jeffrey Esko (University of California-San Diego, USA)
"The amazing proteoglycans of model organisms" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:05 pm | Bryan Toole (Medical University of South Carolina, USA)
"Hyaluronan in tumorigenesis" |
9:05 pm - 9:20 pm | Discussion |
9:30 pm | Discussion at Posters |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |