| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome by Conference Chair / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | RECENT BREAKTHROUGHS IN THE UNDERSTANDING OF MECHANISMS RELATED TO THE BIOSYNTHESIS OF GLYCOSAMINOGLYCANS |
| Discussion Leader: Vincent Hascall (Lerner Research Institute, Cleveland, USA) |
| 7:40 pm - 8:00 pm | Christian Götting (Herz- und Diabeteszentrum Nordrhein-Westfalen, Germany)
"Xylosyltransferases and their role in fibrosis and tissue remodeling" |
| 8:00 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:15 pm | Marco Maccarana (Lund University, Sweden)
"Identification of a second DS-epimerase, genetically linked to bipolar disorder" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:40 pm | Lena Kjellen (The Biomedical Center, Uppsala, Sweden)
"PAPS makes a difference" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Naoko Nagai (Aichi Medical University, Japan)
"Regulation of heparan sulfate 6-O-sulfation by β-secretase activity" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:20 pm | Alberto Passi (University of Insubria, Varese, Italy)
"Intracellular synthesis of hyaluronan" |
| 9:20 pm - 9:25 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | INTERACTIONS AND OUTCOMES |
| Discussion Leader: Jeremy Turnbull (University of Liverpool, UK) |
| 9:00 am - 9:20 am | John Gallagher (University of Manchester, UK)
"Design and function of heparan sulfate" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Julie Leary (University of California, Davis, USA)
"New advances in ion mobility mass spectrometry for proteoglycan analysis" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Deirdre Coombe (Curtin University of Technology, Perth, Australia)
"Characterization of the binding of heparin to Interleukin-5 (IL-5)" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Dave Fernig (University of Liverpool, UK)
"Single molecule analysis of the dynamics of the formation of complexes of FGF2 with HS co-receptor and FGF receptor" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Anthony Day (University of Manchester, UK)
"TSG-6- a pluripotent inflammatory mediato" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Matthew Nugent (Boston University School of Medicine, USA)
"Catalytic mechanisms involving heparan sulfate-fibronectin interactions" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Deanna Beauvais (University of Wisconsin - Madison, USA)
"Synstatin, a peptide derived from the syndecan-1 core protein, blocks syndecan-regulated αvβ3 integrin activation during angiogenesis" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Anne Woods (University of Alabama at Birmingham, USA)
"Syndecan-4 core protein binds fibronectin HepII domain and modulates focal adhesion formation" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROCESSING AND DEGRADATION |
| Discussion Leader: Bruce Caterson (Cardiff University, Wales) |
| 7:30 pm - 7:50 pm | Hideaki Nagase (Imperial College London, UK)
"Key features regulating ADAMTS4 and 5 activity" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Richard Kenagy (University of Washington, USA)
"Induction of ADAMTS4, tissue plasminogen activator, and hyaluronidase 2 by cell death plays a general role in vascular atrophy" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Jennifer Velasco (Rush University Medical Center, USA)
"ADAMTS5 ablation alters migration and differentiation of cells in the activated synovium in murine OA" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Thomas Hering (Case Western Reserve University, USA)
"Size and chondroitinase ABC susceptibility of calf and steer aggrecan monomers" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Linda Troeberg (Kennedy Institute of Rheumatology, UK)
"The anti-arthritic agent calcium pentosan polysulfate inhibits aggrecanase-mediated breakdown of the cartilage extracellular matrix" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Jin-Ping Li (University of Uppsala, Sweden)
"Heparanase - key regulator of heparan sulfate metabolism and pathophysiology" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DEVELOPMENT |
| Discussion Leader: Roberto Perris (University of Parma, Italy) |
| 9:00 am - 9:20 am | H. Joseph Yost (University of Utah School of Medicine, USA)
"Sulfotransferases in Zebrafish development" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | W. Scott Argraves (Medical University of South Carolina, USA)
"Versican-fibulin interaction and the development of the heart" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Hideto Watanabe (Aichi Medical University, Japan)
"In vivo function of versican/PG-M: analysis of knock-in mice" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Mariana Capurro (Sunnybrook Research Institute, Toronto, Canada)
"The regulation of embryo size by Glypican-3 is partially mediated by Indian Hedgehog signaling" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Charles Emerson (Boston Biomedical Research Institute, USA)
"Sulfatases in neurogenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Andreas Faissner (Ruhr University, Germany)
"A role for chondroitin sulfate in neural glial cell differentiation and neurogenesis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Bradley Olwin (University of Colorado, USA)
"Syndecan-3-dependent Notch signaling is required for cell fate regulation in muscle progenitor cells" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Kenneth Kramer (National Institutes of Health, Bethesda, MD, USA)
"A trafficking tool for dissecting the role of heparan sulfate" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEOGLYCANS IN CELL BIOLOGY, PHENOTYPIC CONTROL & SIGNALING |
| Discussion Leader: Pascale Zimmermann (Catholic University Leuven, Belgium) |
| 7:30 pm - 7:50 pm | John Couchman (University of Copenhagen, Denmark)
"Syndecan signaling and integrin-mediated adhesion" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Guido David (University of Leuven, Belgium)
"A novel syntenin-pathway, downstream of syndecan, supporting processes of vesicular 'budding'" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Tarja Kinnunen (University of Liverpool, UK)
"C. elegans syndecan, SDN-1, and Wnt signalling function synergistically in neuron migration" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Markku Tammi (Kuopio University, Finland)
"Microvillus: A hyaluronan synthesizing organelle that influences cell shape" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | William Stallcup (Burnham Institute for Medical Research, La Jolla, CA, USA)
"Phosphorylation of NG2 regulates cell proliferation and migration" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PROTEOGLYCANS AND INFLAMMATION |
| Discussion Leader: Liliana Schaefer (University of Frankfurt, Germany) |
| 9:00 am - 9:20 am | Pyong Park (Harvard Medical School, Boston, USA)
"Syndecan 1 shedding modulates inflammatory responses to infectious agents" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Jacob van den Born (University Medical Center Groningen, The Netherlands)
"Heparan sulfate and leukocyte invasion" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Joanne Tobacman (University of Illinois at Chicago, USA)
"Silencing N-acetylgalactosamine 4-sulfatase reduces TNF-a stimulation of IL-8 secretion and Increases IL-8 sequestration by chondroitin-4-sulfate" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Charles Frevert (University of Washington, Seattle, USA)
"The glycosaminoglycan-binding domain of CXC-chemokines controls neutrophil migration into the lungs of mice" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Toshihiko Toida (Chiba University, Japan)
"Chondroitin sulfate in allergy and inflammation" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Paul Kubes (University of Calgary, Alberta, Canada)
"Hyaluronan complexes promote leukocyte recruitment and inflammation" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Mary Chang (University of Washington, Seattle, USA)
"Altered proteoglycan expression associated with monocyte-to-macrophage differentiation: Potential role for macrophage proteoglycans in matrix stabilization" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Rashmin Savani (Univ. of Texas Southwestern Medical Center, USA)
"Transgenic overexpression of rhamm in macrophages results in increased inflammatory responses" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | PROTEOGLYCANS IN CARDIOVASCULAR DISEASE AND CANCER |
| Discussion Leader: Renato Iozzo (Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA) |
| 7:30 pm - 7:50 pm | Merv Merrilees (The University of Auckland, New Zealand)
"Versican and the inhibition of atherosclerosis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Sarah Wilcox-Adelman (Boston Biomedical Research Institute, USA)
"Syndecan-4 modulates components of the leading edge in migrating cells" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Eva Turley (University of Western Ontario, Canada)
"CD44-RHAMM interactions and the motility of breast cancer cells" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Silvia Goldoni (Thomas Jefferson University, Philadelphia, USA)
"An anti-metastatic role for decorin in breast cancer" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Ralph Sanderson (University of Alabama at Birmingham, USA)
"Targeting the heparan sulfate/heparanase axis for cancer therapy" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PROTEOGLYCANS IN THE MUSCULOSKELETAL SYSTEM |
| Discussion Leader: Anna Plaas (Rush University, Chicago, IL) |
| 9:00 am - 9:20 am | Alan Grodzinsky (Massachusetts Institute of Technology, Cambridge, USA)
"Aggrecan structure and molecular mechanics: a biomarker" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Katalin Mikecz (Rush University Medical Center, Chicago, USA)
"Visualization of joint inflammation in proteoglycan-induced arthritis" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Xingbin Ai (Boston Biomedical Research Institute, USA)
"Sulfs regulate angiogenesis during skeletal muscle regeneration" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Kazu Matsumoto (The Burnham Institute for Medical Research, La Jolla, CA, USA)
"BMP signaling is the major target for the regulatory function of heparan sulfate during skeletal development" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Michael Sohaskey (University of California, Berkeley, USA)
"JAWS coordinates chondrogenesis and synovial joint positioning" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Anne Marie Malfait (Pfizer Global Research and Development, St. Louis, USA)
"Biological implications of ADAMTS4/TS5 inhibition" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Cheryl Knudson (East Carolina University, Greenville, NC, USA)
"Reversible dedifferentiation alters BMP7 responsiveness" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Aimin Wang (The Cleveland Clinic Foundation, OH, USA)
"Is the Adipocyte the Trojan Horse of Diabetic Osteopenia?" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEOGLYCANS IN TRANSLATIONAL RESEARCH: THERAPEUTICS |
| Discussion Leader: Marian Young (National Institute of Dental and Craniofacial Research, Bethesda, MD, USA) |
| 7:30 pm - 7:50 pm | Glen Prestwich (University of Utah, Salt Lake City, USA)
"Pragmatic hyaluronan hydrogels for cell therapy and reparative medicine" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | James Fawcett (University of Cambridge, UK)
"The use of chondroitinase therapy to treat spinal cord injury" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Robert Lindhardt (Rensselaer Polytechnic Institute, NY, USA)
"New avenues for developing glycosaminoglycan-based therapeutics" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Tim Hardingham (University of Manchester, UK)
"Chondrogenic differentiation of human stem cells to generate scaffold-free cartilage" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Discussion at Posters |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
