| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Late Breaking Developments / Frontiers in Proteoglycan Research in Health and Disease |
| 7:40 pm - 7:45 pm | Discussion Leader: Renato Iozzo (Thomas Jefferson University, USA) |
| 7:45 pm - 8:25 pm | Bjorn Olsen (Harvard, USA)
"Unexpected matrix diseases and novel therapeutic strategies" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:05 pm | Jeffrey Esko (University of California, USA)
"Proteoglycan-Mediated Delivery of High-Molecular Weight Cargo to Cells" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Jeremy Turnbull (University of Liverpool, UK)
"Sequence-specific HS modulation of FGF signalling using functional glycoarrays and ES-MS sequencing strategies" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | GAG Synthesis, Assembly and Function: Spanning the Phyla; Basic to Applied |
| Discussion Leader: Jeffrey Esko (University of California, USA) |
| 9:00 am - 9:20 am | Henry Roehl (University of Sheffield, UK)
"Essential role of ext/dackel and papst1/pinscher in skeletogenesis revealed using zebrafish" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Maurizio Pacifici (Thomas Jeffereson University, USA)
"Heparan sulfate insufficiency and the pathogenesis of Hereditary Multiple Exostoses syndrome" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Myron Hinsdale (Oklahoma State University, USA)
"Renal dysfunction and reduced proteoglycans" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Kevin McCarthy (Louisiana State University Health Sciences Center, USA)
"Cell surface-associated glycosaminoglycan control of integrin expression: a novel mechanism explaining podocyte detachment in diabetes mellitus" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Hannes Bülow (Albert Einstein College of Medicine, USA)
"HS modifications define a functional code by differential control of ligand/receptor interaction" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Jean Spencer (Boston University School of Medicine, USA)
"ChamP analysis of vascular heparan sulfate: domain patterns, binding motifs, and much more" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Young In Oh (CalTech University, USA)
"Synthesis and biological activity of heparan sulfate biomimetic glycopolymers" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Brett Crawford (Zacharon, USA)
"Development of Novel Therapies for Mucopolysaccharidosis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time / Optional Softball Match
Social Chair: Megan Lord (University of New South Wales, Australia) |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Angiogenesis, Cardiovascular Biology and Pathology |
| Discussion Leader: Thomas Wight (Benaroya Research Institute USA) |
| 7:30 pm - 7:50 pm | Jens Fischer (Universität Duisburg-Essen, Germany)
"Small leucine-rich proteoglycans in atherosclerotic lesions: Novel targets of pharmacologic treatment?" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Barbara Triggs-Raine (University of Manitoba, Canada)
"Cardiac pathology in a mouse model deficient in Hyaluronidase 2" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Jane Grande Allen (Rice University, USA)
"Hylauronan and proteoglycans in collagenous engineered tissues and
calcified heart valves" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Juliana L. Dreyfuss (Massachusetts Institute of Technology, USA)
"The role of heparan sulfate in choroidal neovascularization" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Suneel Apte (Cleveland Clinic, USA)
"Versican proteolysis by ADAMTS proteases-Mechanisms and biological implications" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Development |
| 9:00 am - 9:05 am | Discussion Leader: Matthew Hoffman (NIH, USA) |
| 9:05 am - 9:25 am | Xinhua Lin (Cincinnati Children’s Hospital, USA)
"The role glipican protein core and attached GAG in biphasic activites in wnt and Hh signaling and distribution" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Jorge Filmus (University of Toronto, Canada)
"The role of glypican-5 in rhabdomyosarcomas" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Nancy Schwartz (University of Chicago, USA)
"Role of CSPGs in growth factor signaling" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Sarah Knox (NIH, USA)
"Role of proteoglycans and the parasympathetic nervous system during branching morphogenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Martin Hudson (University of Kansas, USA)
"C. elegans axon branch formation is regulated by multiple proteoglycans" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Tabea Dierker (University of Essen, Germany)
"Dual heparan sulfate functions in Sonic hedgehog solubilization and stabilization" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Barbara Bartolini (University of Lund, Sweden)
"Dermatan sulfate epimerase 1 and 2: roles in the synthesis and sulfation of dermatan sulfate iduronic acid domains" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Thao Nguyen (University of Utah, USA)
"Modulating zebrafish heparanome to decipher heparan sulfate-FGF interactions in vivo" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time / Optional Cricket Match |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Stem Cells: Identity and Function |
| Discussion Leader: Catherine Merry (University of Manchester, UK) |
| 7:30 pm - 7:50 pm | Lianchun Wang (University of Georgia, USA)
"Heparan Sulfate Is Required For Cell Fate Commitment Of Embryonic Stem Cells" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Bruce Caterson (Cardiff University, UK)
"Chondroitin Sulphate Glycobiology in the Stem/Progenitor Cell Niche" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Brian Bigger (University of Manchester, UK)
"Heparan sulphate storage and stem cell migration in disease" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Becki Holley (University of Manchester, UK)
"Use of HS oligos to functionalize biomaterial scaffolds for ES cell culture and differentiation" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Lola Reid (University of North Carolina, NC)
"Lineage restriction of stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Skeletal Biology: Biomarkers and the Bone: Cartilage Interface |
| Discussion Leader: Tim Hardingham (University of Manchester, UK) |
| A. Genes and Development |
| 9:00 am - 9:20 am | Shiro Ikegawa (Center for Genomic Medicine, Japan)
"From genome to skeletal diseases- recent advances in the association
study of osteoarthritis and lumbar disc herniation and its association with ECM biology" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Hideto Watanabe (Aichi Medical University)
"Versican facilitates chondrocyte differentiation and regulates joint morphogenesis" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Anders Aspberg (University of Copenhagen)
"Normal skeletal development but disturbed perineural net formation in knock-in mice with deleted aggrecan C-type lectin repeat" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | John Whitelock (University of New South Wales, Australia)
"Heparan Sulfate dependent signaling of fibroblast growth factor (FGF) 18 by chondrocytederived perlecan" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:45 am | Coffee Break |
| B. Signaling, Disease and Therapy |
| 10:45 am - 10:55 am | Andrea Vortkamp (University of Duisburg-Essen)
"Molecular characterization of osteochondroma development in mice" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:10 am | Agnes Berendsen (NIH, USA)
"A Novel Mechanism for Modulation of Canonical Wnt Signaling by the ECM Component, Biglycan" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Morten Karsdal (Nordic Bioscience, Denmark)
"Aggrecan degradation is associated with both reversible and irreversible tissue damage - Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics and separated in time ex vivo" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Martha Gray (MIT, USA)
"Molecular imaging of GAGs to monitor OA disease progression" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time / Optional Soccer Match |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Inflammation: From Tolerance to Autoimmunity |
| Discussion Leader: Carol DeLa Motte (Cleveland Clinic, USA) |
| 7:30 pm - 7:50 pm | Paul Bollyky (Benaroya Research Institute, USA)
"The development of ECM-based tools for the induction of immune tolerance" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Akira Asari (Hyaluronan Reserch Institute, Japan)
"Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via toll-like receptor 4 in the intestinal epithelium" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Liliana Schaefer (University of Frankfurt, Germany)
"Biglycan signaling: Toll-like receptors, the NLRP3-inflammasome and beyond" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Nicholas Shworak (Dartmouth Medical School, USA)
"Unique role of anticoagulant heparan sulfate in antithrombin anti-inflammatory signaling" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Richard Stevens (Brigham and Women’s Hospital, USA)
"Mast cell-restricted serglycin proteoglycan-protease complexes in innate immunity, inflammation, and connective tissue remodelling" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cancer |
| Discussion Leader: Ralph Sanderson (University of Alabama, USA) |
| 9:00 am - 9:20 am | Andreas Friedl (USA)
"Regulation of Extracellular Matrix Fiber Organization and Carcinoma Cell Motility by Stromal Syndecan-1" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Vivien J. Coulson-Thomas (Universidade Federal de San Paulo, Brazil)
"Fibroblast and prostate tumor cell cross-talk: fibroblast differentiation, TGFβ and extracellular matrix down-regulation" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Israel Vlodavsky (Israel)
"Heparanase: one molecule with multiple functions in cancer and other diseases" |
| 10:15 am - 10:25 am | Discussion |
| 10:25 am - 10:45 am | Coffee Break |
| 10:45 am - 10:55 am | Anurag Purushothaman (University of Alabama, USA)
"Heparanase mediated loss of nuclear syndecan-1 enhances histone acetyltransferase activity and gene expression to promote an aggressive tumor phenotype" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 11:10 am | Hassan Lemjabbar-Alaoui (University of California, San Francisco, USA)
"Pharmacologic Inhibition of Sulf-2 in lung cancer cells reverts transformed phenotype" |
| 11:10 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Melanie Simpson (University of Nebraska, USA)
"Hyaluronan accumulation or steroid sequestration: outcomes of aberrant glucuronidation" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Daniel Grass (Medical University of South Carolina, USA)
"Interactions between hyaluronan, CD44 and CD147 (emmprin; basigin) regulate properties of highly tumorigenic subpopulations of cancer cells" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Martin Thelin (University of Lund, Sweden)
"Lentiviral vector-mediated downregulation of DS-epimerase 1 in a squamous cell carcinoma cell line results in increased cell size and altered golgi localization" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time / Optional Soccer Match |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Poster Awards |
| Leader: Robert Linhardt (Conference Vice Chair) |
| 7:40 pm - 9:30 pm | Proteoglycans in Translational Research: Therapeutics |
| Discussion Leader: Robert Linhardt (Rensselaer Polytechnic Institute, USA) |
| 7:40 pm - 7:55 pm | Robert Mecham (Washington University School of Medicine, USA)
"Vascular extracellular matrix and vessel wall development" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:15 pm | David McQuillan (Life Cell, USA)
"Matrix-Directed Regeneration of Soft Tissues" |
| 8:15 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:30 pm | Glen Prestwich (University of Utah, USA)
"Therapeutic Uses of Sulfated Polysaccharide RAGE Antagonists: Novel Modulators of Inflammatory Response" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:45 pm | Anders Malmstrom (University of Lund, Sweden)
"Mechanisms of Action for Tafoxiparin Belonging to a Novel Class of Heparin Derived Compounds - Low Anticoagulant Heparin (LAH) - on Human Labor" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:00 pm | Kuby Balagurunathan (University of Utah)
"Heparanomics: Biosynthesis, Structures and Functions" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Yu Yamaguchi (Burnham Institute for Medical Research, USA)
"HS-proteoglycan animal models of autism" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
