Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
The Dynamic Remodeling of Proteoglycans
Discussion Leaders: Velina Bachvarova (University of Duisburg-Essen, Germany) and Raymond Smith (Institute of Medical Biology, A*STAR, Singapore)
3:45 pm - 3:55 pm
Rana Ismail El Masri (Institute for Structural Biology, France)
"The Recognition of Heparan Sulfate by Extracellular Endosulfatase HSulf2: A Cooperative Hunting Process"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 4:10 pm
Kaori Oshima (University of Colorado Denver, USA)
"Downregulation of Sulfatase-1 in Pulmonary Endothelial Cells Contributes to Post-Septic Compensatory Anti-Inflammatory Response Syndrome"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Anna Bång-Rudenstam (Lund University, Sweden)
"Cancer Cell-Surface Proteoglycan Expression Remodeling in the Acidic Tumor Niche: Implications for Proteoglycan-Dependent Uptake of Extracellular Vesicles and Lipoproteins"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Proteoglycans as Extracellular Regulators of Cell Behavior
Discussion Leaders: Sheona Drummond (University of Manchester, United Kingdom) and Yan Wang (Lerner Research Institute, Cleveland Clinic, USA)
7:30 pm - 7:40 pm
Jennifer Ashworth (University of Nottingham, United Kingdom)
"Self-Assembling Peptide Hydrogels as Fully-Defined, Tuneable Matrix Environments for Dissecting the Roles of Matrix Components in Disease"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Jessica Pihl (University of Copenhagen, Denmark)
"Characterizing the Interaction Between rVAR2 and ofCS: A Novel Glycosaminoglycan Cancer Specific Biomarker"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Lauren Pepi (University of Georgia, USA)
"Assignment of C-5 Uronic Acid Stereochemistry in Synthetic Heparan Sulfate Glycosaminoglycan Hexasaccharides by Electron Detachment Dissociation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Taasin Srivastava (Oregon Health and Science University (OHSU), USA)
"Role of Hyaluronan in Perinatal White Matter Injury"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Daiana Vitale (Research and Transfer Center of Northwest of Buenos Aires, Argentina)
"Down-Regulation of UDP-Glucose Dehydrogenase Affects Epirubicin Response and Extracellular Matrix Components in MDA-MB-231 Breast Cancer Cells"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Maarten Swart (University of Oxford, United Kingdom)
"Regulation of Macrophage Heparan Sulfate Proteoglycans in Rheumatoid Arthritis and Other Chronic Inflammatory Diseases"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Johanne Dubail (Institut Imagine, INSERM U1163, France)
"SLC10A7 Mutations in Human and Mouse Cause a Skeletal Dysplasia with Amelogenesis Imperfecta Mediated by GAG Biosynthesis Defects"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Laura Collins (University of Oxford, United Kingdom)
"Expression and Function of Human Macrophage Heparan Sulphate Proteoglycans"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Disease and Therapeutic Opportunities
Discussion Leaders: Brooke Farrugia (University of Melbourne, Australia) and Caitlin Mencio (National Institutes of Health, USA)
9:00 am - 9:15 am
Myriam Cerezo-Magaña (Lund University, Sweden)
"HSPG-Mediated Extracellular Vesicle Internalization by Cancer Cells: Influence of Tumor Hypoxia and Heparin Affinity EV Surface Proteome Characterization"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Isabella Skandorff Pedersen (University of Copenhagen, Denmark)
"Role of Oncofetal Chondroitin Sulfate in Tumorigenesis and Antitumor Immunity"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Jennifer Beffort-Mbosso (Geneva University Hospitals, Switzerland)
"Use of Glycans to Prevent Intracellular Heparan Sulfate Degradation in Sanfilippo Syndrome"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Vincent Zhang (University of North Carolina at Chapel Hill, USA)
"Patch Grafting Strategies for Transplantation of Stem/Progenitors into Internal Organs"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Argyris Spyrou (Uppsala University, Sweden)
"Heparan Sulfate Alterations of Importance for Brain Tumor Development"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Sarah Delbaere (Ghent University, Belgium)
"Knockdown and Knockout Zebrafish Models for the β4GalT7-Deficient Type of Ehlers-Danlos Syndrome Reveal Distinctive and Overlapping Phenotypic Features"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Gregory Golden (University of California, San Diego, USA)
"Heparan Sulfate Modulates Liver Damage and Mortality During MRSA Sepsis"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
This career panel consists of new, mid-career, and senior investigators with experience in academia and industry. Designed as a forum to share experiences, provide unique perspectives, and answer questions from trainees.
Discussion Leaders: Aaron Petrey (Cleveland Clinic, USA) and Rogier Reijmers (Leiden University Medical Center, The Netherlands)
1:30 pm - 2:30 pm
Panel Discussion
Successful Paths in Proteoglycan Science
Glenn Prestwich (Symic Bio, USA)
Liliana Schaefer (University of Frankfurt, Germany)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
