| 1) Sunday Evening, July 9: | Proteinases in Viral Diseases |
Welcome, Introduction to the meeting: W. Bode
Alan Barrett/CambridgeUK
Peptidases: a Genomic Perspective
Chair: Ben Dunn/Gainesville
Viral Peptidases and Polyprotein Processing
Tim Skern/Vienna
A Papain-like Enzyme modulating Mammalian Protein
Synthesis: the Foot-and-Mouth Disease Virus Leader Proteinase
Michael James/Edmonton
Towards a Cure for the Common Cold: the
Development of Inhibitors of Rhinovirus-2 2A proteinase
Patricia Weber/Kenilworth
Proteases of the Hepatitis C Virus
Welcome Party
| 2) Monday Morning, July 10: | Microbial Proteinases |
Chair: James Travis/Athens
Bacterial Proteinases as Targets for Development of
Second-Generation Antibiotics
James Musser/Montana
Analysis of the Cysteine Protease Made by
Group A Streptococcus, the Human Flesh-Eating Bacterium
Jan Potempa/Athens
Taming of Virulence Factors: The Structure-Function
Relation in Gingipains, Cysteine Proteinases of P. gingivalis
Coffee Break/Photo
Kohei Oda/Kyoto
CLN2-related Pepstatin-insensitive Bacterial Aspartyl Proteinases
Robert Liddington/SanDiego
Structural Studies of the Anthrax Lethal Toxin
Mathias Bochtler/Martinsried
The Structure of HslVU: an ATP-dependent
Proteinase and a Model System for the Proteasome
Lowri Phylip/Cardiff
A Protein Inhibitor folded by its Target Proteinase
Poster Session I: first half
| 3) Monday Evening, July 10: | Proteinases in Antigen Presentation |
Chair: Vito Turk/Ljubljana
Proteinases and Antigen Presentation - present Status
Dieter Broemme/Mt.Sinai
Involvement of CathepsinV in Antigen Presentation
Peter M. Kloetzel/Berlin
The Proteasome Inhibitor PI31: exploited by Adenovirus to achieve Immune Escape
Colin Watts/Dundee
Processing and Presentation of the Tetanus Toxin Antigen: a key Role for Asparaginyl Endopeptidase
Harold Chapman/SanFrancisco
Role of Cathepsin S in MHC Class II- restricted
Antigen Presentation
| 4) Tuesday Morning, July 11: | Proteinases + Activators/Inhibitors in Haemostasis/Cancer |
Chair: Ed Madison/SanDiego
Hemostasis/Fibrinolysis/Cancer
Robert A. Lazarus
Peptide Exosite Inhibitors of Factor VIIa
Pablo Fuentes/Martinsried
Structure-Function-Relationships of
Thrombin-Thrombomodulin
Tor Ny/Umea
Studies of Plasminogen Activator Inhibitors
Type 1 and 2 to reveal the Mechanisms of Serpin Inhibition and Polymerization
James A. Huntington/Cambridge
The 2.6Å Structure of a Serpin-Protease Complex: A new Mechanism of Protease Inhibition
Coffee Break
Peter Andreasen
Inhibition of PAI-1
Agnes Noel/Liege
Role of PAI-1 in Pathological Angiogenesis
Kent Stewart/Abbott Park
Urokinase: Structure, Function and Inhibition
Lynn Matrisian/Nashville
The Matrix Metalloproteinase Matrilysin in Tumor Progression
Poster Session I
| 5) Tuesday Evening, July 11: | Proteinases in Connective Tissue Remodeling |
Chair: Hideaki Nagase/London
Connective Tissue Remodeling
Zena Werb/SanFrancisco
Finding Substrates for Proteases
John Martignetti/MountSinai
The Inherited Multicentric Osteolysis with
Arthritis Syndrome: its Clinical Features and Genetic Etiology
Robert Marquis/King of Prussia
The Design and In Vivo Evaluation of Potent, Reversible Inhibitors of the Cysteine Protease Cathepsin K
Darwin Prockop/Philadelphia
Procollagen N- and C-Proteinases. Unexpected Role in Development, Disease and Sterility
Harald Tschesche/Bielefeld
Cryptic Proteinases in Fibronectin
| 6) Wednesday Morning, July 12: | Proteinases in Apoptosis and Signal Transduction |
Chair: Guy Salvesen/LaJolla
Cytosolic Proteinase Systems
Nancy Thornberry/West Point
Caspases: Structure, Function, and Inhibition
Charles S. Craik/SanFrancisco
Using Combinatorial Methods
to identify Natural Substrates for Granzymes from Cytotoxic Lymphocytes
Keith D. Wilkinson/Emory
Structure and Physiological Function
of Deubiquitinating Enzymes
Coffee Break
Hiroyuki Sorimachi/Tokyo
Activity and Physiological Regulation of Calpains
John Elce/Kingston
Transgenic Mice lacking Calpain
Pat J. Casey/Duke
Rce1, A Prenyl Protein-Specific Protease
Poster Session II
| 7) Wednesday Evening, July 12: | Proteinases in Processing and Trafficking |
Chair: Donald Steiner/Chicago
An Overview of Precursor Processing in the Secretory Pathway
Nabil.G. Seidah/Montreal
Precursor processing by the mammalian subtilase SKI-1
Lloyd D.Fricker/AlbertEinstein
Regulatory Carboxypeptidases: New Insights from a Dead Enzyme
Roy Black/Seattle
Ecto-Domain Shedding: Multiple Enzymes and Regulatory
Mechanisms
Dusan Turk/Ljubljana
Structural Basis of Cysteine Exopeptidases
| 8) Thursday Morning, July 13: | Proteinases/Inhibitors in Alzheimer's Disease |
Chair: Dennis Selkoe/Harvard
Presenilins, Intramembranous Proteolysis and the
Genesis of Alzheimer's Disease
Christian Haass/Munich
Molecular Mechanisms of Amyloid Generation
Martin Citron/ThousandOaks
Identification and Characterization of beta-Secretase
Sukanto Sinha/SanFrancisco
Beta-Secretase & Gamma-Secretase -
The Enzymology of Beta-Amyloid Formation
Coffee Break
Raphael Kopan/St.Louis
Signal Transduction by Proteolysis: the Notch Pathway
Falk Fahrenholz/Mainz
Identification and Characterization of an alpha-Secretase
David Lomas/Cambridge
Serpin Polymerization and Dementia
Poster Session II
| 9) Thursday Evening, July 13: |
Andrew Docherty/Slough
Targeting Proteases - Opportunities and
Challenges faced by the Drug Industry
James McKerrow/SanFrancisco
Elections, Future Venue
Guy Salvesen/Milton Stubbs
"Award" Presentation
Entertainement
| 10) Friday Morning, July 14: |
Breakfast and Departure
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