| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Regulated Intermembrane Proteolysis |
| Bart De Strooper (K.U. Leuven/V.I.B.): Discussion Leader
APP Processing |
| Rob Rawson (University of Texas Southwestern Medical Center)
SREBP/SCAP |
| Nafi Kopan (Washington University)
Notch |
| Matthew Freeman (MRC)
Rhomboid |
| 9:30 | Chair's Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Synthetic Protease Inhibitors: New Tools and Drug Leads |
| Scott K. Thompson (GlaxoSmithKline): Discussion Leader |
| Ulrike Obst, Ph.D. (Roche Pharmaceuticals)
Novel, Selective Inhibitors of Factor VIIa |
| Brad Katz, Ph.D. (Celera)
Engineering Inhibitors Highly Selective for the S1 Sites of Ser 190 Trypsin-like Serine Protease |
| Scott K. Thompson, Ph.D. (GlaxoSimthKline)
New Heterocyclic Inhibitors of Methionine Aminopeptidase-2 |
| Harold Tschesche, Ph.D. (Universitat Bielefeld, Germany)
Structure-Based Design of Potent MMP Inhibitors of the Basis of a 6H-1,3,4 -Thiadiazine Scaffold |
| Patty Podolin, Ph.D.(GlaxoSmithKline)
Development of Cathepsin S Inhibitors for the Treatment of Inflammatory Diseases |
| Peter Dragovich, Ph.D. (Pfizer)
Orally Bioavailable Human Rhinovirus 3C Protease Inhibitors |
| James Powers (Georgia Tech) Short Talk
New Clan CD protease inhibitors |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Protease Specificity and Biological Function |
| Charles Craik (UCSF): Discussion Leader
Reverse biochemistry: Probing the function of proteases in complex biological systems |
| Matt Bogyo, Ph.D. (Celera)
Functional Proteomic Analysis of Proteolytic Enzymes: Application to the Cysteine Proteases of Plasmodium falciparum |
| Ben Turk (Harvard)
Substrate recognition by anthrax lethal factor |
| Ranabir Sinha Roy (Merck)
Substrate Specificity of DPPIV and Insight into Biological Function |
| Steve Young (Gladstone Institute)
Examining the functional role of prenylprotein endoproteases |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am -12:30 pm | Structural Basis of Protease Function |
| Wolfram Bode: Discussion Leader |
| Piet Gros (University Utrecht, The Netherlands)
Membrane protease OmpT from E. coli |
| Hans Brandstetter (Max-Planck-Institute)
Archaebacterial Tricorn Protease |
| Zongchao Jia (Queen's University)
Activated Catalytic Domain of Rat m-Calpain in the Presence of Calcium |
| Tim Clausen (Max-Planck-Institute)
The Heat Shock Protease HtrA from E. coli |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Microbial Proteases |
| Dan Goldberg (Washington U): Discussion Leader |
| Aaron Mitchell (Columbia)
A fungal proteolytic system that
governs development and virulence |
| Bob Sauer (MIT)
Energy-Dependent Protein Unfolding |
| Dan Goldberg (Washington University)
Genome-wide analysis of Plasmodium hemoglobin degradation |
| Robert Liddington (Burnham Institute)
Structure of anthrax lethal factor |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00am - 12:30 pm | Proteases in Cell Cycle and Cell Death |
| Guy Salvesen (Burnham Institute): Discussion Leader
A little death is good for you |
| Jean-Michael Peters (Research Institute of Molecular Pathology)
Separase |
| Bruce Hay (Caltech)
Drosophila Proteases |
| Peter Vandebabeele (University of Gent)
HtrA2 |
| Hao Wu (Cornell)
Structural Studies of Caspase Inhibitors |
| Karin Rodberg (University of Linkoping)
Lysosomal proteases: important mediators of apoptosis |
| Kevin Tomaselli (IDUN Pharmaceuticals, San Diego)
Caspase inhibitor therapy |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Proteases in the Immune Response and Inflammation |
| Hal Chapman (UCSF): Discussion leader
Proteases and MHC class II function |
| Hidde Ploegh (Harvard)
MHC class II maturation and trafficking |
| Colin Watts (University of Dundee)
AEP activation and function |
| Ira Mellman (Yale)
Role of lysosomal proteases in dendritic
cell maturation |
| Cristoph Peters (Albert-Ludwigs-Universität - Freiburg, Germany)
Legumain Knockout |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Secreted and Membrane Associated Proteases in Cancer and Endocrine Function |
| Bonnie Sloane (Wayne State): Discussion Leader |
| Johanna Joyce (UCSF)
Investigation of matrix-degrading enzymes in multistage tumorgenesis |
| Ed Madison (Corvas)
Structural characterization of matriptase/MT-SP-1 |
| Thomas Bugge (PTRU/OPCB/NIH)
Matriptase/MT-SP1 in mouse development |
| Bonnie Sloane (Wayne State)
Tumor/Host Contribution to Proteolysis In Situ |
| Klaudia Brix (International University Bremen)
Thyroid hormone processing by secreted cathepsins |
| Lisa Coussens (UCSF)
Type I Collagen Remodeling Regulates Vascular Permeability
|
| 6:00 pm | Banquet |
| 7:30 | Keynote address |
| Zena Werb (UCSF)
"The Degradation Monologues" |
| 8:30 pm - 9:15 pm | Elections and Business Meeting |
| 9:30 pm | Party |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
