| Saturday |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Novel Approaches to
Detecting and Altering Proteases |
| Discussion Leader: Antoine Dufour (University of British Columbia, Canada) |
| 3:15 pm - 3:25 pm | Yael Bennun (Institute for Drug Research, The Hebrew University of Jerusalem, Israel)
"Conversion of
Quenched Cathepsin Activity Based Probes to Theranostics Tools" |
| 3:25 pm - 3:30 pm | Discussion |
| 3:30 pm - 3:40 pm | Michael Lane (University of Minnesota, USA)
"Developing Comprehensive Specificity Profiling of Promiscuous Proteases" |
| 3:40 pm - 3:45 pm | Discussion |
| 3:45 pm - 3:55 pm | Jaideep Dudani (Massachusetts Institute of Technology, USA)
"Nanosystems to Profile Disease-Associated Proteases In Vivo" |
| 3:55 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Keynote Session: Discovery and Development of a Protease Inhibitor for Chagas Disease / From Simple Viruses to
Complex Parasites: Targeting Proteases in Infectious Disease |
| Discussion Leader: Laura Edgington-Mitchell (Monash Institute of Pharmaceutical Sciences, Monash University, Australia) |
| 5:30 pm - 6:05 pm | James McKerrow (University of California, San Diego, USA)
"Discovery and Development of a Protease Inhibitor for Chagas Disease" |
| 6:05 pm - 6:10 pm | Discussion |
| 6:10 pm - 6:25 pm | Nyssa Drinkwater (Monash University, Australia)
"Dual Inhibition of
the M1 and M17 Aminopeptidases" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:45 pm | Ashley Matthew (University of Massachuetts Medical School, USA)
"Structure-Based Design of Robust Cross-Genotypic NS3/4A Protease Inhibitors that Avoid Resistance" |
| 6:45 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:05 pm | Michael Winter (University of California, San Francisco, USA)
"Global Identification of Biofilm-Specific Proteolysis in Candida albicans" |
| 7:05 pm - 7:10 pm | Discussion |
| 7:10 pm - 7:25 pm | Hao Li (Agency for Science, Technology and Research (A*STAR), Singapore)
"Identification and Characterization of Novel Microbial Secreted Proteases in Human Skin Disease Pathogenesis" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Regulation of Inflammation,
Immunity and Cancer by Proteases |
| Discussion Leader: Jaideep Dudani (Massachusetts Institute of Technology, USA) |
| 9:00 am - 9:15 am | Vishnu Mohan (Weizmann Institute of Science, Israel)
"Novel Antibody Targeting MMP-7 Shows Therapeutic Potential Against Pancreatic Cancer" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Antoine Dufour (University of British Columbia, Canada)
"Multi-Omics Analysis
of Macrophage Polarization" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Stephanie Ketterer (Albert Ludwigs University of Freiburg, Germany)
"Cell Type-Specific Deletion of Cathepsin D in Murine Breast Cancer" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Darya Tsvirkun (The Hebrew University of Jerusalem, Israel)
"Molecular Imaging of
Cancer Using Cathepsin Targeted CT Contrast Agents" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Maureen Hill (University of Massachusetts Amherst, USA)
"Engineering Caspases with Altered Specificities" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Frederic Couture (Université de Sherbrooke, Canada)
"Secretome Proteomic Analysis Identifies Substrates of the Proprotein Convertase PACE4 in Prostate Cancer" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Panel |
| Discussion Leader: Anthony O'Donoghue (University of California, San Diego, USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Can You Be a Successful Scientist While Maintaining a Healthy Work-Life Balance?" |
|
- James McKerrow (University of California, San Diego, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
