Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Proteases in Life and Disease
Discussion Leader: Oliwia Malon (Wroclaw University of Science and Technology, Poland)
3:15 pm - 3:45 pm
Bob Lazarus (Genentech, Inc., United States)
"To Cleave or Not to Cleave: Lessons Learned from Protease Activators and Inhibitors"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Proteases: Friends or Foes? Proteases in Immunology and Cancer.
Discussion Leader: Robin Krystufek (Institute of Organic Chemistry and Biochemistry AS CR, Czech Republic)
5:30 pm - 5:50 pm
Isabel Pablos (University of British Columbia, Canada)
"SARS-CoV-2 Main Protease 3CLpro Disrupts Antiviral Autophagy by Cleaving Galectin-8"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Peter Grin (Overall Lab, University of British Columbia, Canada)
"Defeating an Antiviral Interferon Response by SARS-CoV-2 Main Protease 3CLpro cleavage of IFN-?1"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Jamie Zhang (Massachusetts Institute of Technology, United States)
"ClpP1 and ClpP1P2 Peptidases Control Alginate Overproduction and Other Virulence-Associated Phenotypes in Pseudomonas Aeruginosa"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Rachael Barry (Imperial College London, United Kingdom)
"Serine Hydrolases and Their Inhibitors in Colonic Inflammation and Colorectal Cancer"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Natalia Cwilichowska (Wroclaw University of Science and Technology, Poland)
"Detection of Tumor Markers in Breast Cancer Using Mass Cytometry"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Understanding and Targeting Proteases
Discussion Leader: William Oyadomari (Federal University of São Paulo (UNIFESP), Brazil)
9:00 am - 9:15 am
Bangyan Xu (The University of Melbourne, Australia)
"Application of Activity-based Probes to Interrogate the Contribution of Cathepsin X to Dendritic Cells"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Meghann Kasal (Massachusetts Institute of Technology, United States)
"Lon Protease Processively Degrades Very Stable Model Substrates Characteristic of HCLR-clade AAA+ Proteases"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Laura Keller (Stanford University, United States)
"Chemoproteomic Profiling Identifies a Human DPP4 Homolog in the Gut Commensal Bacteroides thetaiotaomicron Important for Membrane Integrity"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Fatma Isik Ustok (University of Cambridge, United Kingdom)
"Engineering a Membrane-Independent Human Prothrombinase Through Parsimonious Mutation of Factor Xa"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Joni De Loose (University of Antwerp, Belgium)
"Dipeptidyl Peptidase 9 (DPP9) in Primary Human Blood Cells: an Exploration of Its Activity and Intracellular Localization"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Nathan Leborgne (Institute of Virology and Immunology, Switzerland)
"Cytosolic Serpins Block Proteolysis of DOK3 by Cathepsin G to Regulate Macrophage Inflammation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
Discussion Leader: Konstantinos Kalogeropoulos (Technical University of Denmark, Denmark)
1:30 pm - 2:30 pm
Panel Discussion
Mentoring Session: Science Career Options
Bob Lazarus (Genentech, Inc., United States)
James Huntington (University of Cambridge, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
