Sunday
7:30 PM |
New Aspects of the Anticancer Activity of Nucleosides and Nucleotides |
| 7:40 |
Beverly S. Mitchell, University of North Carolina, Discussion Leader |
| 7:45 |
Donna Shewach, University of Michigan
Mechanism of Cell Killing by Ganciclovir in HSV-TK-Expressing and Non-Expressing Bystander Cells |
| 8:25 |
John A. Secrist III, William B. Parker, Southern Research Institute
4'-Thianucleosides as Anticancer Agents: Back to the Future |
| 9:15 |
Varsha Gandhi, M. D. Anderson Cancer Center
The Anticancer Activity of Ara-G |
| 9:55 |
Chair's Reception - O'Hare Academic Center |
Monday
8:30 AM |
Molecular Structure, Conformation, and Topology of Nucleosides, Nucleotides, and Oligonucleotides |
| 8:30 |
Victor E. Marquez, National Cancer Institute, Discussion Leader |
| 8:40 |
Martin Egli, Northwestern University
Correlating the Structure and Stability/Function of Oligonucleotide Analogues |
| 9:20 |
Juli Feigon, University of California, Los Angeles
Cation Binding and Folding in DNA and RNA |
| 10:00 |
Photograph |
| 10:30 |
Coffee |
| 11:10 |
Eric T. Kool, University of Rochester
Recognition of DNA, RNA, and Proteins by Circular Oligonucleotides |
Monday
4:30 to 6:00 PM |
Poster Session I |
|
Preview - O'Hare Academic Center |
Monday
7:30 PM |
The Role of Enzymology in the Discovery of Biologically Active Nucleosides and Nucleotides |
| 7:30 |
Arnold Fridland, St. Jude's Children's Hospital, Discussion Leader |
| 7:40 |
Vern L. Schram, Albert Einstein College of Medicine
Design of Transition State Inhibitors of N-Ribosyl Transferases |
| 8:20 |
Staffan Eriksson, Swedish University of Agricultural Sciences
The Stereoisomeric Selectivity of Human Deoxyribonucleoside Kinases |
| 9:00 |
Edwin M. Westbrook, Argonne National Laboratories
Crystallographic Studies of Bacterial IMP Dehydrogenase |
Monday
9:30 to 11:00 PM |
Poster Session 1 |
|
O'Hare Academic Center - Carol Cass, Session Leader |
Tuesday
8:30 AM |
Synthesis of Interesting New Nueleosides and Nucleotides |
| 8:30 |
Michael E. Jung, University of California, Los Angeles, Discussion Leader |
| 8:40 |
Morris Robins, Brigham Young University
Mechanism-Based Inhibition of Ribonucleotide Reductase |
| 9:20 |
Hiromichi Tanaka, Showa University
New Aspects of the Lithiation Chemistry of Nucleosides |
| 10:00 |
Coffee |
| 10:40 |
Akira Matsuda, Hokkaido University
Synthesis of Novel Anticancer Nucleosides |
| 11:20 |
Mark D. Erion, Metabasis Therapeutics
Design and Synthesis of Highly Potent and Specific AMP Deaminase Inhibitors |
Tuesday
7-30 Pm |
Transporters of Nucleosides and Nucleobases |
| 7:30 |
Judi Belt, St. Jude's Children's Hospital, Discussion Leader |
| 7:40 |
James D. Young, University of Alberta
Concentrative Transporters of Mammalian Cells |
| 8:20 |
Stephen A. Baldwin, University of Leeds
Equilibrative Transporters of Mammalian Cells |
| 9:00 |
Buddy Ullman, University of Oregon Health Center
Nucleoside Transporters of Parasites |
Wednesday
8:30 AM |
Recent Advances in the Discovery and Mechanism of Action of Novel Antiviral Nucleosides |
| 8:30 |
Vasu Nair, University of Iowa, Discussion Leader |
| 8:40 |
C. K. Chu, University of Georgia
Asymmetric Synthesis of Nucleosides Using Carbohydrate Chiral Templates |
| 9:20 |
Coffee |
| 10:00 |
Norbert Bischofberger, Gilead Sciences, Inc.
Chemistry and Pharmacology of Acyclic Nucleoside Phosphonates |
| 10:40 |
Chris Meier, University of Hamburg
Cyclosal-pro-Nucleotides of Adenosine Derivatives: Efficient Nucleotide Delivery Systems |
| 11:20 |
Leslie Boyd, Glaxo Wellcome, Inc.
Development of Benzimidazoles for HCMV |
Wednesday
4:30 to 6:00 PM |
Poster Session II |
|
Preview - O'Hare Academic Center |
Wednesday
7:45 PM |
DNA Damage and Repair |
| 7:45 |
Leona D. Samson, Harvard University, Discussion Leader |
| 7:55 |
John Essigmann, MIT
Toxin-DNA Adducts that Hijack Transcription Factors |
| 8:40 |
Samuel H. Wilson, NIEHS
Structural Biology of Base Excision Repair |
Wednesday
9:30 to 11:00 PM |
Poster Session II |
|
O'Hare Academic Center - Carol Cass, Session Leader |
Thursday
8:30 AM |
Discovery and Mechanism of Action of Biologically Active Oligonucleotides |
| 8:30 |
Donald E. Bergstrom, Purdue University, Discussion Leader |
| 8:40 |
Laurence H. Hurley, University of Texas, Austin
G-Quadruplexes as Targets for Drug Design |
| 9:20 |
Barbara Ramsay Shaw, Duke University
First and Second Generation Boranophosphate Oligonucleotides |
| 9:40 |
Coffee |
| 10:30 |
Muthiah Manoharan, ISIS Pharmaceuticals
Designer Antisense Oligonucleotides: A Medicinal Chemistry Approach for Tuning Pharmacological and Pharmacokinetic Properties |
| 11:10 |
John Rossi, Beckman Research Institute of City of Hope
Catalytic RNA (Ribozymes) and the Treatment of HIV Infection |
| 5:00 PM |
Reception - O'Hare Academic Center |
| 6:00 PM |
Banquet |
Thursday
7:45 -9:00 PM |
Session on Late-Breakers
|
