| SUNDAY |
| 2:00 pm - 9:00 pm | Arrivals, registration |
| 6:00 pm | Dinner |
| 7:30 pm - 9:00 pm | Conference Overview and Keynote Lecture |
| Discussion leader: Jack Secrist, Southern Research Institute |
| 7:30 pm - 8:00 pm | Introduction and meeting goals |
| 8:00 pm - 8:45 pm | Jean-Pierrre Sommadossi, Idenix Pharmaceuticals
"Antivirals: Yesterday, Today, and Tomorrow" |
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 11:00 pm | Chair's Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Small Molecule Drug Discovery |
| Discussion Leader: Phillip A. Furman |
| Announcements, Jack Secrist |
| 9:00 am - 9:10 am | Introduction, Phil Furman |
| 9:10 am - 9:50 am | Anne Eldrup, ISIS Pharmaceutical Co.
"Structure Activity Relationships and Mechanism of Action of 2ยด-Modified Nucleosides for Inhibition of HCV RNA Dependent RNA Polymerase" |
| Discussion |
| 9:50 am - 10:30 am | GRC Photo session (10 am) and Coffee Break |
| 10:30 am - 11:10 am | Joanne E. Tomassini, Merck Research Laboratories
"Antiviral Effect of 2'-Substituted Nucleoside Analogs upon HCV Replication" |
| Discussion |
| 11:10 am - 11:50 am | Mark Erion, Metabasis Therapeutics, Inc.
"Liver-Targeted Nucleoside Prodrugs" |
| Discussion |
| 11:50 am - 12:30 pm | Shanta Bantia, BioCryst Pharmaceutical Co.
"Purine Nucleoside Phosphorylase Inhibitor BCX-1777 (Immucillin - H) - A Novel Potent T-Cell Selective Immunosuppressive Agent" |
| Discussion |
| 12:30 pm | Lunch
Past chairs meet as Nominating Committee at lunch |
| 1:30 pm - 4:30 pm | Free time |
| 4:30 pm - 6:00 pm | Poster Session I: Synthesis and Biological Evaluations
McAuley Hall, 1st floor. See poster program for schedule. Poster presenters are to be available on their designated day. All posters will remain up all week. |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Chemical Biology of Nucleic Acids |
| Discussion Leader: Jyoti Chattopadhyaya, Uppsala University |
| 7:30 pm - 7:40 pm | Introduction, Jyoti Chattopadhyaya |
| 7:40 pm - 8:15 pm | David R. Liu, Harvard University
"DNA Templates for Small Molecule Synthesis" |
| Discussion |
| 8:15 pm - 8:50 pm | Darrell Davis, University of Utah
"Hypermodified Nucleosides and tRNA Structure" |
| Discussion |
| 8:50 pm - 9:30 pm | Gregory L. Verdine, Harvard University
"Chemical Biology of Base-Excision DNA Repair" |
| Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Enzyme-Focused Strategies |
| Discussion Leader: William K. Plunkett, M. D. Anderson Cancer Center |
| Announcements, Jack Secrist |
| 9:00 am - 9:10 am | Introduction, Bill Plunkett |
| 9:10 am - 9:50 am | Robert D. Kuchta, University of Colorado
"Synthesis of Nucleotide Analogs That Potently and Selectively Inhibit Human DNA Primase" |
| Discussion |
| 9:50 am - 10:30 am | Richard L. Schowen, Kansas University
"Structure Activity Relationships for S-Adenosylhomocysteine hydrolase" |
| Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:40 am | Yves Pommier, National Cancer Institute
"Molecular Basis for Nucleotide Modifications Interfering With DNA Topoisomerase I Functions" |
| Discussion |
| 11:40 am - 12:20 pm | Arnon Lavie, University of Illinois at Chicago
"Structure of Human Deoxycytidine Kinase: Implications for Substrate Specificity" |
| Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session II: Chemistry and Biology of Nucleic Acids |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Oligonucleotides: Synthesis and Evaluation |
| Discussion Leader: Barbara Ramsay Shaw, Ph, D., Duke University |
| 7:30 pm - 7:40 pm | Introduction, Barbara Ramsay Shaw |
| 7:40 pm - 8:15 pm | Serge Beaucage, FDA
"Thermolytic 5'-Hydroxyl and Phosphate Protecting groups Toward the Synthesis of Oligodeoxyribonucleotides on Microarrays" |
| Discussion |
| 8:15 pm - 8:50 pm | Jean-Jacques Vasseur, University of Montpellier
"Synthesis and Studies of New Cationic Oligonucleotides" |
| Discussion |
| 8:50 pm - 9:30 pm | Jesper Wengel, Southern Denmark University
"Optimized LNA Architectures for Nucleic Acid Targeting" |
| Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Small Molecule Properties and Synthesis |
| Discussion Leader: Katherine Seley, University of Maryland Baltimore County |
| Announcements, Jack Secrist |
| 9:00 am - 9:10 am | Introduction, Kathy Seley |
| 9:10 am - 9:50 am | Michal Hocek, Czech Academy of Sciences
"Recent Advances in the Synthesis of Purines Bearing Carbon Substituents" |
| Discussion |
| 9:50 am - 10:30 am | Morris Robins, Brigham Young University
"New Functionalizations and Alkylations of Novel Purines" |
| Discussion |
| 10:30 am - 10:50 am | Coffee Break |
| 10:50 am - 11:30 am | Bilha Fischer, Bar-Ilan University
"Molecular Recognitions of Adenine and Adenine Nucleotides - Evaluation by 15N - NMR and Theoretical Calculations" |
| Discussion |
| 11:30 am - 12:10 pm | P. Dan Cook, Biota, Inc.
Nucleoside Triphosphate Mimics (P3Ms) and Their Prodrugs (P3M-PDs): Novel Anti-HIV Agents" |
| Discussion |
| 12:10 pm - 12:30 pm | Business meeting
Election of Vice Chair
Conference Name discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session III: Structural Biology and Targeted Pharmacology |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Chemistry and Biology of Oligonucleotides and PNA |
| Discussion Leader: Donald E. Bergstrom, Purdue University |
| 7:30 pm - 7:40 pm | Introduction, Don Bergstrom |
| 7:40 pm - 8:15 pm | David Corey, Univ. of Texas Southwestern
"Choosing the Right Chemistry for Recognition of Varied Cellular Targets by Oligonucleotides" |
| Discussion |
| 8:15 pm - 8:50 pm | Eric Wickstrom, Thomas Jefferson Univ.
"Zebrafish Embryonic Gene Knockdown With Alternating Hydroxyprolyl/phosphono PNAs" |
| Discussion |
| 8:50 pm - 9:30 pm | Sudhir Agrawal, Hybridon, Inc.
"Synthetic Immunomodulatory Oligonucleotides" |
| Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm |
Novel Targets and Structures |
| Discussion Leader: Jonathan Maybaum, University of Michigan |
| Announcements, Jack Secrist |
| 9:00 am - 9:10 am | Introduction, Jon Maybaum |
| 9:10 am - 9:50 am | Edward Chu, Yale University
"siRNAs as Novel Molecules to Control the Expression of Thymidylate Synthase and to Reverse Cellular Drug Resistance" |
| Discussion |
| 9:50 am - 10:30 am | Janet A. Houghton, St. Jude Children's Research Hospital
"Modulation of the Fas Signaling Pathway in Therapy of Colon Cancer: Preclinical and Clinical Development" |
| Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:40 am | Varsha Gandhi, M. D. Anderson Cancer Center
"ATP Analogs: Cellular Bioenergetics and Transcription" |
| Discussion |
| 11:40 am - 12:20 pm | Catherine Drennan, MIT
"When Bigger Isn't Better: Crystal Structure of Class II Ribonucleotide Reductase" |
| Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mixed Session: Transport and Synthesis |
| Discussion Leader: Gary Kruh, Fox Chase Cancer Center |
| 7:30 pm - 7:40 pm | Introduction, Gary Kruh |
| 7:40 pm - 8:15 pm | Carol E. Cass, University of Alberta
"Human Nucleoside Transporters: Structure-Activity Studies With Recombinant Proteins" |
| Discussion |
| 8:15 pm - 8:50 pm | Stewart Schneller, Auburn University
"C-5' Modified Derivatives of Aristeromycin" |
| Discussion |
| 8:50 pm - 9:30 pm | John D. Schuetz, St. Jude Children's Research Hospital
"How Knockouts Have Revealed MRP4's Biological and Therapeutic Importance" |
| Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
