Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Statistical Predictions and Models: Causality, Scale and
Experimental Connections
Discussion Leader: Michel Georges (University of Liege, Belgium)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
Sylvia Richardson (University of Cambridge, United Kingdom)
"Statistical Modelling and Analysis of Complex Phenotypes in Genomics"
8:25 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Eric Green (National Human Genome Research Institute, NIH, USA)
"From the Human Genome Project to Precision Medicine: A Journey to Advance Human Health"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genetics
of Risk and Prediction – Applications
Discussion Leader: Lauren McIntyre (University of Florida, USA)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:50 am
Natalia De Leon (University of Wisconsin-Madison, USA)
"The Effect of Artificial Selection on Phenotypic Plasticity in Maize"
9:50 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Iona MacLeod (AgriBio, University of Melbourne, Australia)
"Exploiting Prior Biological Knowledge for Genomic Prediction and Mapping of Causal Variants"
11:15 am - 11:40 am
Discussion
11:40 am - 12:10 pm
David Heckerman (Microsoft Research, USA)
"Surprises in the Statistical Analysis of Associations"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Susan Lamont (Iowa State University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Evolutionary
Contexts for Prediction and Selection
Discussion Leader: Josephine Pemberton (University of Edinburgh, United Kingdom)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
John Novembre (University of Chicago, USA)
"Evaluating Polygenic Signatures of Selection in Ancient DNA"
8:20 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Nicholas Barton (Institute of Science and Technology Austria, Austria)
"Epistasis and the Limits to Selection"
9:10 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic
Context – Making Sense of Multivariate Phenotypes
Discussion Leader: Rebecca Doerge (Carnegie Mellon University, USA)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:50 am
Barbara Engelhardt (Princeton University, USA)
"Heritability, Effect Sizes, and Pleiotropy in Expression QTLs Across Tissues"
9:50 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Eleazar Eskin (University of California, Los Angeles, USA)
"Fine Mapping and Allelic Heterogeneity"
11:15 am - 11:40 am
Discussion
11:40 am - 12:10 pm
Bin Yu (University of California, Berkeley, USA)
"Spatial Gene Expression Patterns in Drosophila : Mapping a Cell's Destiny"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Modeling
of Context – Interaction Terms and Beyond
Discussion Leader: Bruce Walsh (University of Arizona, USA)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
Ian Ehrenreich (Translational Imaging Center, University of Southern California, USA)
"Genetic Architectures of a Complex Trait Across Backgrounds and Environments"
8:20 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Paul Magwene (Duke University, USA)
"Exploring Pleiotropy and Epistasis Using a Novel Yeast Mapping Panel"
9:10 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Late-Breaking Topics
Discussion Leader: Peter Visscher (University of Queensland, Australia)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:50 am
Gustavo Stolovitsky (Translational Systems Biology and Nanobiotechnology Group, IBM, USA)
"Crowdsourcing Biological Network Inference, Drug Synergy Prediction and Beyond: The DREAM Challenges"
9:50 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Matthew Webster (Uppsala University, Sweden)
"The Genomic Basis of Local Adaptation in Honeybees"
11:15 am - 11:40 am
Discussion
11:40 am - 12:10 pm
Alexis Battle (Johns Hopkins University, USA)
"Predicting the Complex and Cascading Impact of Non-Coding Variation"
12:10 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Context
– Drugs, Weather and the Systems to Integrate Genotypes and Environments
Discussion Leader: Ed Buckler (Agricultural Research Service, USDA / Cornell University, USA)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
Mark Cooper (DuPont Pioneer, USA)
"Crop Modeling and Genomic Prediction"
8:20 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Sally Aitken (University of British Columbia, Canada)
"How Does Adjusting for Population Structure Alter Polygenic Signals of Local Adaptation to Climate?"
9:10 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Quantitative
Perspectives on Gene Editing – Why to Edit What
Discussion Leader: Ann Stapleton (University of North Carolina at Wilmington, USA)
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:50 am
Kevin Esvelt (Massachusetts Institute of Technology, USA)
"Daisy Drives for Grassroots Ecological Engineering"
9:50 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Mattheos Koffas (Rensselaer Polytechnic Institute, USA)
"Rewiring Cellular Metabolism Using Metabolic Flux Analysis Models for Chemical Production"
11:10 am - 11:30 am
Discussion
11:30 am - 11:45 am
Karl Kremlng (Cornell University, USA)
"The Regulatory Consequences of Ancestral and Modern Rare Variants in Maize"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Nichol Schultz (University of Wisconsin-Madison, USA)
"Improved Mapping and Genomic Prediction in Populations Featuring Shared Environments and Familial Relatedness"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Katie Lotterhos (Northeastern University, USA)
"Data Visualization Gives Novel Insights into Adaptation to Multivariate Environments"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Next
Generation Quantitative Genetics and Genomics
Discussion Leader: Mike Goddard (University of Melbourne, Australia)
7:30 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
Christine Queitsch (University of Washington, USA)
"Hyper-Variable Genetic Elements in Complex Trait Genetics"
8:20 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
Jeff Leek (Johns Hopkins Bloomberg School of Public Health, USA)
"What Can We Learn from Analyzing Every Human RNA-Seq Sample Ever Collected Together?"
9:10 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure