Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Radionuclides and Molecular Targeting
Session in memory of Sam Gambhir and Tom O'Dorisio
Discussion Leader: Michael Schultz (Viewpoint Molecular Targeting, Inc., United States)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
Richard P. Baum (CURANOSTICUM Wiesbaden-Frankfurt, Germany)
"Radiomolecular Precision Oncology: The Coda to Theranostics"
8:25 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Leila Safavi (Purist Inc., United States)
"From Reactors to Bedside: Securing the Medical Radioisotope Supply Chain"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Current Radiotherapeutics and Theranostics in Oncology
Discussion Leader: Joseph Dillon (University of Iowa, United States)
9:00 am - 9:20 am
David Bauer (Memorial Sloan Kettering Cancer Center, United States)
"Targeting Ligands for Theranostics; mAbs, Peptides, Pre-Targeting, and the Emerging Future"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Katharina Lueckerath (University Hospital Essen / University Duisburg-Essen, Germany)
"Harnessing the Tumor Microenvironment - FAP and Beyond"
9:45 am - 9:55 am
Discussion
9:55 am - 10:15 am
Jolanta Kunikowska (Nuclear Medicine Department, Medical University of Warsaw, Poland)
"Treatment of Glioma with Radiolabelled Substance-P and PSMA"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Ken Herrmann (University of Duisburg-Essen, Germany)
"CXCR4 Based Theranostics"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Izabela Tworowska (RadioMedix Inc, United States) and Ebrahim Delpassand (RadioMedix, United States)
"Targeted Alpha Particle Therapy (212Pb) in PRRT Naïve Patients - A Promising Future Is Here"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Chandrasekhar Bal (All India Institute of Medical Sciences, New Delhi, India)
"Targeted Alpha Particle Therapy (225Ac) in Stable or Refractory PRRT Setting"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Andreas Kjaer (Rigshospitalet / University of Copenhagen, Denmark)
"68Ga-NOTA-AE105 uPAR PET in Patients with Neuroendocrine Neoplasms: Implications for uPAR Targeted Therapy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Elcin Zan (NYU Langone Health, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Dosimetry-Guided Therapy with Radionuclides
Discussion Leader: Alan Packard (Boston Children's Hospital/Harvard Medical School, United States)
7:30 pm - 7:50 pm
Kuangyu Shi (Inselspital, University of Bern, Switzerland)
"Integrated Artificial Intelligence and Systems Biology for Personalised Radioligand Therapy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Dale Bailey (GenesisCare, Australia)
"Making Dosimetry Mainstream for Radionuclide Therapy for Cancer in Australia"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Stephen Graves (University of Iowa, United States)
"Incorporation of Dosimetry into Clinical Practice"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Bryan Bednarz (University of Wisconsin - Madison, United States)
"Challenges and Opportunities in the Dosimetry of Alpha Emitter Therapy"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development of Theranostic Radiopharmaceuticals
Discussion Leaders: Jonathan McConathy (University of Alabama at Birmingham School of Medicine, United States)
9:00 am - 9:20 am
Andrew Bellizzi (University of Iowa Hospitals and Clinics, United States)
"Immunohistochemistry to Confirm Protein Targets in Cancer Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Benjamin Larimer (University of Alabama at Birmingham, United States)
"Development of Peptide-Based Radiopharmaceuticals - Native Peptides and Discovery Approaches"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:50 am
Richard Wahl (Washington University--Mallinckrodt Institute of Radiology, United States)
"Radiolabeled Monoclonal Antibodies for Radiotheranostics"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Sherly Mosessian (SOFIE, United States)
"Current Status of Clinical Trials on FAP Targeted Radiopharmaceuticals"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Germo Gericke (Advanced Accelerator Applications, a Novartis Company, Switzerland)
"Innovation in Radionuclide Thera(g)nostics: The Road(s) Ahead"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Comprehensive Approach to Brain: Targeting the Blood Brain Barrier and Beyond with Radiotheranostics
Discussion Leader: Andrei Iagaru (Stanford University, United States)
7:30 pm - 8:00 pm
Michelle James (Stanford University, United States)
"Overcoming the Barriers to Better Understand and Treat Brain Diseases Using PET"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Corinne Beinat (Stanford University, United States)
"From Brain PET Imaging to Peptide Receptor Radionuclide Therapy"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Gary Kohanbash (University of Pittsburgh, United States)
"Glioma Associated Immune Cells: Potential Targets for Novel Theranostics Molecules"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Optimizing Therapy for Cancer Using Theranostics
Discussion Leaders: Michael Schultz (Viewpoint Molecular Targeting, Inc., United States)
9:00 am - 9:20 am
David Faul (Siemens Medical Systems, United States)
"PET Imaging Advancements for Radionuclide Theranostics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Geoffrey Johnson (Mayo Clinic, United States)
"Emerging Imaging Technologies for Theranostics - Gamma Camera to CZT SPECT"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Charles Kunos (University of Kentucky, United States)
"Modern Approach to the Development of Radiopharmaceutical Therapies"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Susanne Kossatz (Klinikum rechts der Isar at Technical University Munich, Germany)
"Exploring the Potential of PARP Inhibition to Sensitize SSTR2-Positive Small Cell Lung Cancer to 177Lu-DOTA-TOC PRRT"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Zachary Morris (University of Wisconsin School of Medicine and Public Health, United States)
"The Combination of Radionuclide Therapy and Immunotherapy - Emerging Understanding"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Josh Mailman (NorCal CarciNET, United States)
"Patient Perspective on Sequencing Therapies"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Design of Theranostic Clinical Trials
Discussion Leader: Elcin Zan (NYU Langone Health, United States)
5:30 pm - 5:50 pm
Philip Harris (ITM Isotope Technologies Munich SE, Germany)
"From Clinical Trials to EMA/FDA approval"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Emily Bergsland (University of California, San Francisco, United States)
"Pragmatic Clinical Trials Design in Theranostics"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 7:00 pm
Amanda Walker (Novartis, United States)
"Regulatory Considerations in the Development of Radioligand Therapy: US FDA Perspective"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Advances in Radionuclide Theranostics
Discussion Leaders: Giuseppe Carlucci (UCLA, United States) and Yusuf Menda (University of Iowa, United States)
9:00 am - 9:20 am
Johannes Notni (TRIMT GmbH, Germany)
"Small Change, Big Impact: A Holistic View on Pharmacokinetics of Radiometallated Peptide Multimers"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Daniel Pryma (University of Pennsylvania, United States)
"Towards Precision Radioligand Therapy: Total Body PET in Treatment Planning"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stephen Graves (University of Iowa, United States)
"Combination Radionuclide Therapy: Dose Limiting Organ Differences in MIBG and PRRT for Maximizing Tumor Dose With Dosimetry"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Brian Miller (The University of Arizona, United States)
"New Instrumentation for Detection of Alpha-Particle Effects in Tumor and Normal Tissues"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Diana Zepeda-Orozco (Nationwide Children's Hospital, United States)
"New Biomarkers for Kidney Injury in the Development of Radiopharmaceuticals"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Radiation Biology and Theranostics: Current Knowledge and Emerging Understanding
Discussion Leader: Katharina Lueckerath (University Hospital Essen / University Duisburg-Essen, Germany)
7:30 pm - 7:50 pm
Jean-Pierre Pouget (INSERM, France)
"Revisiting the Radiobiology of Targeted Alpha Particle Therapy for Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Samantha Terry (King's College London, United Kingdom)
"Radiobiology and Theranostics - Principles, Understanding, and Research Needs"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Julie Constanzo (INSERM, France)
"Role of cGAS and Extracellular Vesicles in Adaptive Immunity Induced by Targeted Radionuclide Therapy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure