| MONDAY |
| 9:00 am - 12:30 pm | Molecular Biology of Membrane Proteins |
| Discussion Leader: Vann Bennett |
| Vann Bennett and Diana Gilligan
"Primary structure and domain organization of human α and β Adducin" |
| Bernie Forget
"Structure and function of α and β spectrin" |
| John Winkleman
"Differential splicing of 3'-human β spectrin genes in murine cells" |
| Carl Cohen
"Biochemistry and molecular biology of protein 4.2" |
| Samuel Lux
"Ankyrin: Structure and function" |
| Velia Fowler
"Tropomodulin: A novel tropomyosin regulatory protein" |
| 7:30 pm - 9:30 pm | Hematopoiesis and Gene Transfer |
| Discussion Leader: Arthur Nienhuis |
| Ihor Lemischka
"Developmental, cellular and molecular properties of hematopoietic stem cells" |
| Keith Humphries
"Regulation and genetic manipulation of the most primitive hematopoietic cells" |
| Siu-Wah Chung
"Immortalized cells with hematopoietic stem cell properties" |
| David Bodine
"Gene transfer into hematopoietic stem cells" |
| Steve Emerson
"Support of hematopoiesis and gene transfer in proliferative human cultures in vitro" |
| TUESDAY |
| 9:00 am - 12:30 pm | Membrane Proteins: Organization & Regulation |
| Discussion Leader: Jon Morrow |
| Jon Morrow and Scott Kennedy
"Conformational control of ankyrin binding" |
| Richard Waugh
"Mechanical function of red cell membrane skeletal proteins" |
| Joel Chasis
"Integral proteins: Role in membrane organization and membrane properties" |
| Phil Low
"Tyrosine-kinase regulation of red cell metabolism" |
| David Speicher
"The mechanism of spectrin dimer-tetramer conversion: The role of the open chain form and temperature" |
| Edward Benz
"Protein 4.1: Structure and function" |
| 7:30 pm - 9:30 pm | Transcription Factors |
| Discussion Leader: Doug Engel |
| Joe Knezetic
"Mechanism of developmental regulation of the chicken embryonic α-globin gene" |
| Stuart Orkin
"Regulation of erythroid development in vitro and in vivo" |
| Beverly Emerson
"Developmental regulation β-globin transcription in vitro" |
| Todd Evans
"Regulation of erythroid expression by GATA-1" |
| Doug Engel
"β-globin gene switching" |
| WEDNESDAY |
| 9:00 am - 12:30 pm | Role of Membrane Proteins in Normal and Pathologic Red Cells |
| Discussion Leader: Robert Hebbel |
| Robert Hebbel
"Membrane iron in red cell pathobiology: Facts and fallacies" |
| Stanley Schrier
"Cellular and membrane pathology of thalassemic red cells" |
| Jiri Palek
"Molecular defects of band 3 protein" |
| Robert Johnson
"Band 7 in hereditary stomatocytosis" |
| Bertram Lubin
"Lipid and protein interactions on pathologic red cells" |
| Ross Coppel
"Interaction between malarial proteins and the red cell membrane" |
| 7:30 pm - 9:30 pm | Regulation of Globin Gene Expression |
| Discussion Leader: Y.W. Kan |
| Y.W. Kan
"Regulation of globin gene expression" |
| F. Grosveld
"Developmental regulation of the human β-globin locus" |
| P. Ney
"Purification of a 47 kDa HS-II enhancer binding protein" |
| D. Tuan
"Promoter-independent transcription of the HS-II enhancer" |
| J. Lloyd
"Human γ-β globin gene switching in mini-construct in transgenic mice" |
| G. Dover
"Pharmacological switching of fetal hemoglobin in man and monkeys" |
| THURSDAY |
| 9:00 am - 12:30 pm | Molecular Analysis of Red Cell Transport Proteins, Glycolytic Enzymes and Blood Group Antigens |
| Discussion Leader: Joseph Hoffman |
| Joe Hoffman
"Na/K/Cl co-transport system and regulation of steady state red cell volume" |
| Peter Agre and G. Preston
"A novel 28kD membrane channel from red cells" |
| Ron Kopito
"Biosynthesis and function of erythroid and non-erythroid anion exchangers" |
| Denise Goodman
"Assessment of high energy metabolic dynamics in intact erythrocytes" |
| M. Tanner
"Membrane protein alterations in unusual red blood cells" |
| E. Beulter
"Glucose-6-phosphate dehydrogenase" |
| 7:30 pm - 9:30 pm | Minisymposium on the Red Cells |
| Discussion Leader: Peter Agre |
| Speakers: Rose Johnstone, G.W. Stewart, Philipe Gascard, Jean Delaunay, David Liu, Colvin Redman, Jack Goldstein, David Daleke, John Conboy, Marilyn Telen, Terry Bishop, George Dale |
| FRIDAY |
| 9:00 am - 12:30 pm | Cell-cell Interactions and Erythropoiesis |
| Discussion Leader: David Williams |
| David Williams
"Molecular biology of steel gene locus" |
| Vikram Patel
"Adhesion of hematopoietic stem cells and erythroid progenitor cells to bone marrow stroma" |
| Laura Coulombel
"Integrins in Human Erythroblasts" |
| Thalia Papayannopoulou
"Surface and functional properties of erythroid progenitor cells" |
| Mehdi Tavassoli
"Hematopoetic cell-stromal cell interactions" |
