| MONDAY |
| 9:00 am - 12:30 pm | Advances In Membrane Biology Derived from Red Cell Studies |
| Discussion Leader: Vann Bennett, Duke Univ. |
| Ronald R. Dubreuil, University of Chicago, IL
"A molecular and genetic approach to the membrane skeleton in Drosophila" |
| William James Nelson, Stanford Univ. School of Medicine, Stanford, CA
"Localization of a spectrin isoform in the golgi complex of non-erythroid cells" |
| Anthony P. Bretscher, Cornell University, Ithaca, NY
"Ezrin and moesin in the cortical cytoskeleton of non-muscle cells" |
| Carol Gregorio, The Scripps Research Institute, La Jolla, CA
"Tropomodulin: an actin filament regulatory protein in red cells and muscle" |
| Vann Bennett and Stephen Lambert, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NO
"Ankyrins and specialized cell domains in the nervous system" |
| LuAnne Peters, Children's Hospital, Boston, MA
"Cloning, sequencing, chromosomal localization and tissue distribution of an axonal and epithelial ankyrin, Ank-3, in the mouse" |
| 7:30 pm - 9:30 pm | Globin Gene Regulation |
| Discussion Leader: Frank Grosveld, Erasmus Univ. |
| Frank Grosveld, Erasmus University, Rotterdam, Holland
"β-globin regulation by the LCR" |
| George Stamatoyannopoulos, Univ. of Washington, Seattle
"Developmental Control of Human Globin Genes" |
| Mark Groudine, Hutchinson Cancer Center, Seattle, WA
"The human β-globin LCR" |
| Margaret Baron, Harvard University, Cambridge, MA
"Regulation of the human embryonic β-globin gene is mediated by synergistic interactions among multiple DNA elements" |
| TUESDAY |
| 9:00 am - 12:30 pm | Erythroid Transcription Factors |
| Discussion Leader: Stuart Orkin, Harvard Univ. Med |
| Gary Felsenfeld, NIH, Bethesda, MD
"Chromatin structure and the regulation of globin gene expression" |
| Beverly Emerson, Salk Institute, La Jolla, CA
"Developmental regulation of β-globin transcription in vitro" |
| Stuart Orkin, Hughes Medical Institute, Boston, MA
"New insights into the roles of GATA-1 and GATA-2" |
| Paul-Henri Romeo, Hopital Henri Mondor, Paris, France
"Studies of erythroid gene expression" |
| Stephen Jane, NIH, Bethesda, MD
"New mechanisms for γ-globin gene regulation" |
| James J. Bieker, Mount Sinai School of Medicine, New York, NY
"Molecular analyses of EKLF, an erythroid specific transcription factor" |
| 7:30 pm - 9:30 pm | Molecular Basis of Membrane Transport |
| Discussion Leader: Jerry Lingrel, Univ. of Cincinnati School of Med. |
| Ron Kopito, Stanford University, Stanford, CA
"Plasma membrane anion exchangers" |
| Michael L. Jennings, Univ. of Texas Med. Branch, Galveston, TX
"Structure-function relations in the human red cell anion transporter" |
| Mike M. Muekler, Washington Univ. School of Medicine, St. Louis, MO
"The Glut1 and Glut4 glucose transporters" |
| WEDNESDAY |
| 9:00 am - 12:30 pm | Non-Globin Gene Expression |
| Discussion Leader: Bernard G. Forget,Yale Univ. School of Med. |
| Jane E. Barker, The Jackson Laboratory, Bar Harbor, ME
"Different ankyrin and β-spectrin isoforms in the mouse" |
| Edward J. Benz, University of Pittsburgh, School of Medicine, Pittsburgh, PA
"Genomic structure and regulated splicing of protein 4.1 gene" |
| John G. Conboy, Lawrence Berkeley Lab, Berkeley, CA
"Changes in protein 4.1 structure and function during erythroid differentiation, mediated by alternative splicing" |
| Jean Delaunay, Faculte de Medecine Grange-Blanche, Lyon, France
"Allele αLELY, a low expression allele of the α-spectrin gene: Possible impairment of the spectrin dimer nucleation site" |
| John Winkelmann, Univ. of Minnesota Medical School, Minneapolis, MN
"Alternative splicing of the human erythrold β-spectrin gene" |
| 7:30 pm - 9:30 pm | Embryogenesis |
| Discussion Leader: Doug Melton, Harvard Univ. |
| Gordon Keller, National Jewish Hospital, Denver, CO
"Hematopoietic development of embryonic stem cells in culture" |
| Doug Melton, Harvard University, Cambridge, MA
"Induction of globin gene expression and mesoderm in Xenopus" |
| Roger Patient, King's College, London, UK
"Expression of GATA-2 is an early marker for blood" |
| Leonard I. Zon, Children's Hospital, Boston, MA
"Induction of hematopoiesis during Xenopus embryogenesis" |
| THURSDAY |
| 9:00 am - 12:30 pm | Red Cell Structural Proteins and Membrane Integrity |
| Discussion Leader: Mohandas Narla, Lawrence Berkeley Lab. |
| Philip S. Low, Purdue University, West Lafayette, IN
"Regulation of interactions between band 3 and tyrosine kinases" |
| Athar H. Chishti, St. Elizabeth Hospital, Boston, MA
"Dematin and P55: two novel components of erythroid junctional complex" |
| Mike Tanner, University of Bristol, Bristol, UK
"Associations and structure of red cell band 3" |
| 7:30 pm - 9:30 pm | Selected Posters |
| Discussion Leader: Peter Agre, Johns Hopkins |
| (selected poster presentations) |
| FRIDAY |
| 9:00 am - 12:30 pm | Erythropoiesis / Hematopoiesis |
| Discussion Leader: David A. Williams, Indiana Univ. |
| Hartmut Beug, Research Institute for Molecular Pathology, Vienna, Austria
"Self-renewing red cell progenitors: Induction by cooperating nuclear hormone receptors and tyrosine kinases" |
| Stanford B. Krantz, Vanderbilt University
"Use of highly purified human erythroid progenitor cells to determine specific growth factor requirements and cytokine effects" |
| Sandra Ruscetti, NCI
"Transactivation of erythroid specific gene by a myb/ets-containing retrovirus" |
| David A. Williams, Howard Hughes Medical Institute, Herman B. Wells Center for Pediatric Research, Indiana Univ. School of Med.
"Molecular characterization of stromal-derived growth factors IL-11 and Steel factor" |
| Neal Young, NIH
"Molecular and cellular basis for B19 erythroid tropism" |
