| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ERYTHROID GENE EXPRESSION: MEMBRANE PROTEINS |
| Discussion Leader: David M. Bodine (National Institutes of Health, Bethesda, MD) |
| 7:30 pm - 8:00 pm | John G. Conboy (Lawrence Berkeley National Laboratory, Berkeley, CA)
"Regulation of Alternative Splicing of 4.1R Pre-mRNA" |
| 8:00 pm - 8:30 pm | Anthony Baines, University of Kent, UK
"Isoform-Specific Activities and Regulation of Beta-II Spectrin Splice Variants" |
| 8:30 pm - 9:00 pm | David M. Bodine (National Institutes of Health, Bethesda, MD)
"Insulators in Erythroid Specific Gene Expression" |
| 9:00 pm - 9:30 pm | Patrick G. Gallagher (Yale University, New Haven, CT)
"Regulation of Ankyrin 1 Gene Expression" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ERYTHROID GENE EXPRESSION: GLOBIN / LCR |
| Discussion Leader: Douglas R. Higgs (University of Oxford, Oxford, United Kingdom) |
| 9:00 am - 9:25 am | Douglas R. Higgs (University of Oxford, Oxford, United Kingdom)
"Regulation of Alpha Globin Expression" |
| 9:25 am - 9:50 am | Frank Grosveld (Erasmus University, Rotterdam, The Netherlands)
"Control of Globin Gene Expression" |
| 9:50 am - 10:15 am | Gerd Blobel (Children's Hospital of Philadelphia, Philadelphia, PA)
"Mechanisms of Gene Activation by GATA-1" |
| 10:15 am - 11:15 am | Coffee Break and Group Photo |
| 11:15 am - 11:40 am | Peter Fraser (The Babraham Institute, Cambridge, United Kingdom)
"Long-Range LCR-Gene Interactions" |
| 11:40 am - 12:05 pm | Mitchell J. Weiss (Children's Hospital of Philadelphia, Philadelphia, PA)
"Genetic Interactions between Beta Thalassemia and AHSP, an Erythroid Alpha Globin Stabilizing Protein" |
| 12:05 pm - 12:25 pm | Che-Kun James Shen (IMB, Academia Sinica, Taipei, Taiwan)
"Regulation of Factors Regulating the Globin Gene Transcription" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | MEMBRANE STRUCTURE, TRANSPORT AND ADHESION |
| Discussion Leader: Peter C. Agre (Johns Hopkins University, Baltimore, MD)
|
| 5:30 pm - 6:00 pm | Peter C. Agre (Johns Hopkins University, Baltimore, MD)
"Aquaporins-Discovered in Red Cells but Important Everywhere Else" |
| 6:00 pm - 6:30 pm | Michael J.A. Tanner (University of Bristol, Bristol, United Kingdom)
"A Macrocomplex of Red Cell Band 3 and Rh Proteins - Potential Role
as a Gas Exchange Metabolon" |
| 6:30 pm - 7:00 pm | Philip S. Low (Purdue University, West Lafayette, IN)
"Regulation and Assembly of an Enzyme Complex on the Cytoplasmic Domain of Band 3" |
| 7:00 pm - 7:30 pm | David J. Anstee (Bristol Institute for Transfusion Sciences,
Bristol, United Kingdom)
"Structure and Function of ICAM-4" |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MEMBRANE STRUCTURE AND MECHANICS |
| Discussion Leader: Narla Mohandas (New York Blood Center, New York, NY) |
| 9:00 am - 9:25 am | Mohandas Narla (New York Blood Center, New York, NY)
"Dynamic Regulation of Red Cell Membrane Skeletal Protein Interactions In Situ" |
| 9:25 am - 9:50 am | Kenneth P. Ritchie (Nagoya University, Nagoya, Japan)
"Probing Membrane Skeleton Structure Using Optical Force Microscopy" |
| 9:50 am - 10:15 am | Yves Colin (INSERM U76, Paris, France)
"Rh Protein/ Ankyrin-R/ Protein 4.2 Complex : A New Major Interaction Site between the Membrane Bilayer and the Red Cell Skeleton" |
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Jon S. Morrow (Yale University, New Haven, CT)
"Selective Membrane Biogenesis Controlled by the Spectrin-Ankyrin Tethering System" |
| 11:10 am - 11:35 am | Erich Sackmann (Technische Universitat Munchen, Garching, Germany)
"Micro-Viscoelasticity of Composite Cell Membranes" |
| 11:35 am - 12:00 pm | Athar H. Chishti (St. Elizabeth's Medical Center Tufts University, Boston, MA)
"Cytoskeletal Signaling via mu-Calpain" |
| 12:00 pm - 12:25 pm | Evan Evans (University of British Columbia, Vancouver, Canada and
Boston University, Boston, MA)
"Mechanical Strengths of Single Adhesion Bonds to Integrins and Selectins on Blood Cell Membranes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | TRANSCRIPTION |
| Discussion Leader: James J. Bieker (Mount Sinai School of Medicine, New York, NY) |
| 5:30 pm - 6:40 pm | Keynote Speaker: Rudolf Grosschedl (Gene Center and Institute of Biochemistry, University of Munich, Munich, Germany)
"PML Nuclear Bodies: Effects of Chromatin" |
| 6:40 pm - 7:05 pm | James J. Bieker (Mount Sinai School of Medicine, New York, NY)
"EKLF: A Globin Switching Factor" |
| 7:05 pm - 7:30 pm | Beverly Emerson (The Salk Institute, San Diego, CA)
"A Cell Specific Chromatin Associated Complex Involved in Globin Production" |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RED CELL DISORDERS |
| Discussion Leader: Nancy C. Andrews (Boston Children's Hospital, Boston, MA) |
| 9:00 am - 9:25 am | Thomas E. Wellems (National Institutes of Health, Bethesda, MD)
"Chloroquine-Resistant Malaria" |
| 9:25 am - 9:50 am | Kirk W. Deitsch (Cornell University, New York, NY)
"Life Inside the Red Cell: Variation by Malaria Parasites" |
| 9:50 am - 10:15 am | Kasturi Haldar (Northwestern University, Chicago, IL)
Anthony A. Holder (National Institute for Medical Research, London, United Kingdom)
"Rafts in the Infection of Erythrocytes by Malaria Parasites"
|
| 10:15 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Gilbert Jean Tchernia (Hopital Bicetre, Paris, France)
"Diamond Blackfan Anemia: From Erythroblast to Prolactin" |
| 11:10 am - 11:35 am | Nancy C. Andrews (Boston Children's Hospital, Boston, MA)
"Perturbations of Iron Balance-Not Just Hemochromatosis" |
| 11:35 am - 12:00 pm | Carole Beaumont (INSERM, Faculte Xavier Bichat, Paris, France)
"Hepcidin as Regulator of Iron Absorption and Iron Storage" |
| 12:00 pm - 12:25 pm | G. Vann Bennett (Duke University, Durhan, NC)
"Ankyrin-B Mutation Causes Sudden Cardiac Death in Mice and Men" |
| 12:30 pm | Lunch |
| 1:30 pm - 5:30 pm | Free Time |
| 5:30 pm - 7:30 pm | STEM CELLS |
| Discussion Leader: Stuart H. Orkin (HHMI/Children's Hospital, Boston, MA) |
| 5:30 pm - 5:55 pm | Stuart H. Orkin (HHMI/Children's Hospital, Boston, MA)
"Hematopoietic Stem Cell Genes: Formation and Function" |
| 5:55 pm - 6:20 pm | Masayuki Yamamoto (University of Tsukuba, Tsukuba, Japan)
"GATA-2 Function in HSC and Progenitor" |
| 6:20 pm - 6:45 pm | Tariq Enver (Institute of Cancer Research, London, United Kingdom)
"A Network of Factors Determines Stem Cell Differentiation" |
| 6:45 pm - 7:05 pm | Anna Rita Migliaccio (Istituto Superiore di Sanita, Rome, Italy)
"Erythropoietin Signaling" |
| 7:05 pm - 7:25 pm | Margaret H. Baron (Mount Sinai School of Medicine, New York, NY)
"Dynamic In Vivo Imaging of Embryonic Hematopoietic and Vascular Development" |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HEMATOPOIESIS |
| Discussion Leader: Roger K. Patient (University of Nottingham Institute of Genetics, Nottingham, United Kingdom) |
| 9:00 am - 9:25 am | Roger K. Patient (University of Nottingham Institute of Genetics, Nottingham, United Kingdom)
"Fate Mapping of Definitive Hematopoiesis" |
| 9:25 am - 9:50 am | Leonard I. Zon (HHMI/Children's Hospital, Boston, MA)
"Dissecting Hematopoiesis using Zebrafish" |
| 9:50 am - 10:10 am | Kyunghee Choi (Washington University, St. Louis, MO)
"SCL is Required for Hemangioblast Differentiation" |
| 10:10 am - 10:30 am | Toru Nakano (Osaka University, Osaka, Japan)
"Context Dependent Function of Hematopoietic Transcription Factors" |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | Nancy A. Speck (Dartmouth Medical School, Hanover, NH)
"Runx1 is Required for Stem Cell Production" |
| 11:25 am - 11:50 am | Elaine Dzierzak (Erasmus University, Rotterdam, The Netherlands)
"The AGM Source of Stem Cells" |
| 11:50 am - 12:10 pm | Todd R. Evans (Albert Einstein College of Medicine, Bronx, NY)
"Regulation of erythropoiesis by the BMP signaling pathway" |
| 12:10 pm - 12:30 pm | Bruno Peault (Children's Hospital in Pittsburgh, PA)
"Very Emergence of Hematopoietic Stem Cells in the Human Embryo" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | SELECTED TALKS FROM POSTER PRESENTATIONS |
| Discussion Leader: Vincent T. Marchesi (Yale University School of Medicine, New Haven, CT) |
| 5:30 pm - 5:50 pm | Robert A. Schulz (MD Anderson Cancer Center, Houston, TX)
"Genetic Analysis of Hematopoiesis in Drosophila" |
| 5:50 pm - 6:10 pm | Rainer Prohaska (University of Vienna, Vienna, Austria)
"Overexpressed Stomatin is Targeted to Lipid Droplets" |
| 6:10 pm - 6:30 pm | Ann Dean (National Institutes of Health, Bethesda, MD)
"A Globin Enhancer Causes Both Discrete and Widespread Alterations in Chromatin Structure" |
| 6:30 pm - 6:50 pm | Yuichi Takakuwa (Tokyo Women's Medical University, Tokyo, Japan)
"Modulation of Erythrocyte Membrane Stability by PKC Phosphorylation of Protein 4.1" |
| 6:50 pm - 7:10 pm | Paresh Vyas (University of Oxford, Oxford, United Kingdom)
"Transcriptional Regulation of GATA-1" |
| 7:10 pm - 7:30 pm | James Palis (University of Rochester, Rochester, NY)
"Primitive Red Cells Enucleate in the Mouse Embryo" |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
