SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Membrane Skeleton Organization and Dynamics |
| Discussion Leader: Velia Fowler (Scripps) |
7:40 pm - 8:00 pm | Vann Bennett (Duke) "An ankyrin/spectrin based mechanism for biogenesis of the epithelial lateral membrane" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Luanne Peters (Jackson Labs) "Scatological Research" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Dennis Discher (UPenn) "Foreign vs Self interactions with human Macrophages - from Red Cells to Particles, Viruses, and Stem Cells" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Ron Dubreuil (Univ of Ill) "Genetic studies in Drosophila suggest a two-tier model for the spectrin cytoskeleton" |
9:15 pm - 9:20 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Transcriptional Control of Gene Expression |
| Discussion Leader: Gerd Blobel (UPenn) |
9:00 am - 9:20 am | Stuart Orkin (Harvard) "Control of human γ-globin gene silencing by BCL11A" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Masi Yamamoto (Tohoku Univ) "GATA factor switching during erythroid differentiation" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Mitch Weiss (UPenn) "Graded repression of Pu.1/Sfpi1 transcription by GATA factors regulates lineage choice" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Doug Engel (Univ of Michigan) "Targets and partners in the DRED repressor complex" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Emery Bresnick (Univ of Wisconsin) "Dissecting GATA Factor Mechanisms Genome-Wide" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Len Zon (Harvard) "The Role of Transcriptional intermediary factor TIF1γ during hematopoiesis" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Gerd Blobel (UPenn) "Mechanisms of GATA factor dependent transcriptional regulation" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Erythroid Epigenetics |
| Discussion Leader: Emery Bresnick (Univ of Wisconsin) |
7:30 pm - 7:50 pm | Frank Grosveld (Erasmus Univ) "Transcription factor networks and long-range interactions" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Gordon Ginder (Virginia Commonwealth Univ) "Methylated Cytosine Binding Proteins and Developmental Globin Gene Regulation" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Ann Dean (NIH) "Function of Ldb1/NLI in erythroid differentiation" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Dave Bodine (NIH) "Epigenetic changes during erythropoiesis and hematopoiesis" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Doug Higgs (Oxford) "Role of the chromatin-associated ATRX protein in regulation of alpha-globin gene expression" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Membrane Biogenesis, Maturation, and Enucleation |
| Discussion Leader: Pat Gallagher (Yale) |
9:00 am - 9:20 am | Jon Morrow (Yale) "Spectrin-Dependent Erythrocyte Membrane Biogenesis" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Michel Vidal (Univ of Montpellier) "Erythrocyte membrane remodeling: contribution of the exosome pathway" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | John Crispino (Northwestern Univ) "Novel insights into the mechanisms of erythroblast enucleation" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Melissa Rhodes (Ohio State Univ) "Macrophages mediate extrinsic loss of transferrin receptors from circulating reticulocytes" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Peng Ji (MIT) "Nucleus condensation and plasma membrane rearrangement in the final stages of erythropoiesis" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Theodosia Kalfa (Univ of Cincinnati) "Rac GTPases in erythropoiesis and erythrocyte membrane biology" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Mohan Narla (NY Blood Center) "New Insights into Dynamics of Red Cell Membrane Structural Organization" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Infected Red Cells |
| Discussion Leader: Mohan Narla (NY Blood Center) |
7:30 pm - 7:50 pm | Thomas Wellems (NIH) "Erythrocyte and parasite determinants of virulence in malaria" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Athar Chishti (Univ of Illinois) "Merozoite invasion in red cells" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Elisabeth Winzeler (Scripps) "Systems biology of malaria parasites" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Kasturi Haldar (Univ of Notre Dame) "Secretomes in red cell remodeling: from algorithms to essential functions" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Jen-Tsan Chi (Duke) "Genomic analysis of erythrocyte microRNAs" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Developmental Controls in Erythropoiesis |
| Discussion Leader: Doug Engel (Univ of Michigan) |
9:00 am - 9:20 am | Kyunghee Choi (Wash Univ Sch of Med) "Cooperative regulation of primitive erythropoiesis by Runx1 and TGF-beta signaling" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Don Wojchowski (Maine Med Center) "Novel EPO receptor response circuits, and proerythroblast stage-specific utilization" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Lily Huang (UT Southwestern) "Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Bob Paulson (Penn State Univ) "Regulation of stress erythropoiesis by BMP4 and Hedgehog" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Kay Macleod (Univ of Chicago) "Unique functions of E2F-2 in erythroid differentiation" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Andrew Perkins (Univ of Queensland) "A forward genetic screen for mutants of definitive erythropoiesis" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | John Conboy (Berkeley) "Stage-Specific Switches in Alternative Pre-mRNA Splicing during Late Erythropoiesis" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Erythroblast Maturation |
| Discussion Leader: Jim Palis (Univ of Rochester Sch of Med) |
7:30 pm - 7:50 pm | Jim Palis (Univ of Rochester Sch of Med) "Emergence of definitive erythropoiesis in the mammalian embryo" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Joel Chasis (Berkeley) "Erythroblastic Islands: Niches for Erythropoiesis" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Margaret Baron (Mt. Sinai Sch of Med) "Development and maturation of primitive erythroid cells" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Jan Abkowitz (Univ of Washington) "Heme trafficking, erythropoiesis, and iron homeostasis" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Paul Ney (St. Jude’s) "Mechanisms of mitochondrial clearance in reticulocytes" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 9:30 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:30 am - 12:30 pm | Membrane Proteins: Structures and Associations |
| Discussion Leader: Jon Morrow (Yale) |
9:30 am - 9:50 am | Phil Low (Purdue Univ) "Characterization of RBCM structure by analysis of band 3 diffusion using single molecule videomicroscopy" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:15 am | Lesley Bruce (Bristol Institute) "Membrane alterations in cation leaky red cells" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Pat Gallagher (Yale) "Identifying Determinants of Erythrocyte Hydration" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:35 am | Miljan Simonovic (Univ of Illinois) "Structure of the ankyrin-binding region of the erythroid b spectrin and its interactions with ankyrin" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Alfonso Mondragon (Northwestern Univ) "Structural basis for spectrin recognition by ankyrin" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Xiuli An (NY Blood Center) "Modulation of red cell membrane organization by phosphorylation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Red Cell Disorders |
| Discussion Leader: Len Zon (Harvard) |
7:30 pm - 7:50 pm | Alan D’Andrea (Harvard) "Fanconi Anemia: Molecular Defect and Stem Cell Dysfunction" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Jeff Miller (NIH) "Understanding erythroblast expression of GDF15 in health and disease" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Stefano Rivella (Cornell Univ) "Ineffective erythropoiesis and iron metabolism in beta-thalassemia: the role of Jak2 and Hepcidin" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Alex Sheftel (Institut für Zytobiologie, Marburg) "Red bloodedness would not be possible without the exquisite relationship between iron and heme" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Deliang Zhang (NIH, NICHD) "FPN1B, a novel ferroportin transcript lacking an iron responsive element, enables duodenal and erythroid precursor cells to evade translational repression" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |