SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Developmental Biology of Erythropoiesis |
| Discussion Leader: Kyungchee Choi (Washington Univ) |
7:40 pm - 7:58 pm | Kyungchee Choi (Washington Univ)
"ER71 Function in Flk-1+ Hemangioblast and Hematopoietic Development" |
7:58 pm - 8:02 pm | Discussion |
8:02 pm - 8:20 pm | Nancy Speck (Univ Penn)
"Blood Cell Formation from Hemogenic Endothelium" |
8:20 pm - 8:24 pm | Discussion |
8:24 pm - 8:42 pm | Margaret Baron (Mt. Sinai)
"Development and Differentiation of Embryonic Erythoid Progenitors" |
8:42 pm - 8:46 pm | Discussion |
8:46 pm - 9:04 pm | Hannah Mikkola (UCLA)
"Mechanisms Regulating Hematopoietic Stem/Progenitor Cell Development and Differentiation During Embryogenesis" |
9:04 pm - 9:08 pm | Discussion |
9:08 pm - 9:26 pm | Len Zon (Harvard)
"Signaling Pathways that Regulate Transcriptional Control of Hematopoiesis" |
9:26 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Erythroid Epigenetics |
| Discussion Leader: Emery Bresnick (Univ Wisconsin) |
9:00 am - 9:20 am | Emery Bresnick (Univ Wisconsin)
"From Chromatin Occupancy to Function: Bridging the Deep Divide" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Marjorie Brand (Ottawa Hospital Res Inst)
"The Role of Histone Methylation in Regulating Gene Expression During Erythropoiesis" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Stuart Orkin (Harvard Univ)
"Hemoglobin Switching" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Group Photo / Coffee Break |
10:45 am - 11:05 am | Frank Grosveld (Erasmus Univ)
"Factors, Looping and Transcriptional Control" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Ross Hardison (Penn State)
"Dynamics of the Epigenetic Landscape Regulating Gene Expression During Erythroid Differentiation" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Andrew Perkins (Univ Queensland)
"KLF1 Networks in Erythropoiesis" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Mitch Weiss (Univ Penn)
"Insights into Down Syndrome Hematopoiesis and GATA1 Function Through Analysis of Patient-Derived Induced Pluripotent Stem Cells" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Erythropoiesis, Signaling and Red Cell Production |
| Discussion Leader: Don Wojchowski (Maine Medical Center) |
7:30 pm - 7:50 pm | Don Wojchowski (Maine Medical Center)
"Novel Mediators of EPO/EPOR Action" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Saghi Ghaffari (Mt Sinai)
"Dissecting Erythroid Cell Development with Forkhead Transcription Factors" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Wenqian Hu (MIT)
"An Erythroid-Specific Long Non-coding RNA that Prevents Apoptosis of Erythroid Progenitors and Promotes Terminal Proliferation" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Robert Paulson (Penn State)
"Regulation of Stress Erythropoiesis by Interactions Between Progenitor Cells and the Microenvironment" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Scott Peslak (University of Rochester) "EPO-Mediated Expansion of Late-Stage Erythroid Progenitors in the Marrow is Essential for Recovery of the Erythron Following Clastogenic Injury" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Erythrocyte Terminal Maturation |
| Discussion Leader: Joel Chasis (Lawrence Berkeley Nat Lab) |
9:00 am - 9:05 am | Joel Chasis (Lawrence Berkeley Nat Lab) "Introduction" |
9:05 am - 9:25 am | Merav Socolovsky (Univ Mass)
"An S Phase-Dependent Epigenetic Switch in Erythropoiesis" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Takahiro Maeda (Beckman Res Inst, City of Hope)
"Regulation of Transferrin Receptor Internalization by the Clathrin Assembly Protein PICALM" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:15 am | Ashley Toye (Univ Bristol)
"Studying Red Cell Membrane Biogenesis using Cultured Human Erythroblasts" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Shilpa Hattangadi (MIT and Harvard University) "The Role of Exportin 7 (RanBP16) in Erythroid Chromatin Condensation and Enucleation" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Maki Murata-Hori (National Univ Singapore)
"Regulation of Cell Polarity During Mammalian Erythroblast Enucleation" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Theodosia Kalfa (Cincinnati Children's Hospital Medical Center)
"Requirement and Distribution of Signaling Molecules for Erythroblast Enucleation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | John Crispino (Northwestern Univ)
"Vesicle Trafficking in Enucleation" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transcriptional Control of Gene Expression |
| Discussion Leader: Mitch Weiss (Univ Penn) |
7:30 pm - 7:50 pm | Gerd Blobel (Univ Penn)
"Lineage-specific mitotic bookmarking by transcription factor GATA-1" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Monika Kowalczyk (Univ Oxford) "An Unexpected Source of Erythroid Specific Transcription" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Jim Bieker (Mt Sinai) "Transcriptional Fine-Tuning by EKLF/KLF1" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Ann Dean (NIH) "Function of Ldb1 in Long Range Chromatin Interactions" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Peter Fraser (Babraham Res Inst)
"How do transcription factors control erythroid transcription; EKLF vs GATA1" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Membrane Protein Structures, Associations and Functions |
| Discussion Leader: Luanne Peters (NY Blood Center) |
9:00 am - 9:20 am | Luanne Peters (NY Blood Center)
"RASA3 Plays a Critical Role in Vertebrate Erythropoiesis" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Athar Chishti (Tufts Univ)
"A Novel Tripartite Complex in the Erythrocyte Membrane" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Dennis Discher (Univ Penn)
"Mass Spec Probing of Normal & Mutant RBCs and HSCs: From Probes of Folding & Assembly to Label-Free Quantitation" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | David Speicher (Wistar Inst)
"Effects of HE Mutations on Red Cell Spectrin Structure and Dynamics" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Teruhisa Hirai (RIKEN Harima Inst)
"Three-Dimensional Structure of AE1 Membrane Domain Revealed by Electron Crystallography" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Taina Franco (Purdue Univ) "Mapping of the Adducin and Ankyrin Binding Sites on the Cytoplasmic Domain of Band 3" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:15 pm | Franco Turrini (Univ Turin) "Role of Band 3 Post-translational Modifications in Red Cell Membrane Adaptive Response to Oxidant Stress" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Iron, Heme and the Red Cell |
| Discussion Leader: Barry Paw (Harvard) |
7:30 pm - 7:50 pm | Barry Paw (Harvard)
"Mitoferrin1 and AtpIF1: Regulators of Mitochondrial Heme Metabolism and Erythropoiesis" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Yelena Ginzburg (NY Blood Center)
"Transferrin and Iron Availability for Erythropoiesis" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Adam Goldfarb (Univ Virginia)
"Configuration of Inflammatory Signal Transduction in Erythroblasts by Iron Availability" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Ella Nemeth (UCLA)
"Regulation of Iron Availability for Erythropoiesis" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Dennis Stuehr (Cleveland Clinic)
"New Mechanisms Regulating Hemeprotein Maturation in Mammals" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Red Cell Disorders |
| Discussion Leader: Stefano Rivella (Weill Cornell Med College) |
9:00 am - 9:20 am | Stefano Rivella (Weill Cornell Med College)
"Macrophages at the Crossroad Between Normal, Stress and Ineffective Erythropoiesis" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Akiko Shimamura (Fred Hutchinson)
"Ribosomes and Genomic Instability in Marrow Failure" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Benjamin Ebert (Harvard Univ)
"Erythropoietic Defects in Myelodysplastic Syndromes and Diamond Blackfan Anemia" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Anna-Rita Migliaccio (Mt. Sinai)
"The Glucocorticoid Receptor as a Host-Genetic Modifier in Polycythemia Vera" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Raffaele Renella (Harvard)
"The Role of Codanin-1 in Erythropoiesis: Lessons from CDA" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Yves Colin (INSERM/Univ Paris Diderot)
"Abnormal Red Cell Adhesion in Human Diseases" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Joanna Flatt (University of Bristol) "Stomatin-Deficient Cryohydrocytosis Results from Mutations in SLC2A1: A Novel Form of Glut1 Deficiency Syndrome" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Parasite Interactions with Red Cells |
| Discussion Leader: Kasturi Haldar (Notre Dame Univ) |
7:30 pm - 7:50 pm | Kasturi Haldar (Notre Dame Univ)
"AnemiaMalaria Invasion: Mechanisms and Links to Inflammatory Disease" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Mary Stevenson (McGill Univ)
"Understanding Suppressed Erythropoiesis in Malarial Anemia" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Sanjay Desai (NIH) "Malaria Parasite clag3 Genes Determine Channel-Mediated Nutrient Uptake by Infected Red Blood Cells" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Jose Stoute (Penn State)
"Antibody-Mediated Enhancement of Red Cell Invasion by Malaria" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Mohandas Narla (NY Blood Center) "Perspectives and Future Directions" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |