SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Developmental Biology of Erythropoiesis |
| Discussion Leader: Len Zon (Harvard) |
7:40 pm - 8:00 pm | Kyunghee Choi (Wash Univ)
"Transcriptional regulation of hemangioblast development"
|
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Nancy Speck (Univ Penn)
"Core binding factors in hematopoietic stem cells"
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8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Len Zon (Harvard)
"Pathways regulating hematopoietic stem cell induction and self-renewal in zebrafish"
|
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Yolanda Sanchez (Dartmouth)
"Rapid fire: uncovering a unique Chk1-sensitive stage in fetal erythropoiesis"
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9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Epigenetics of Erythroid Cells |
| Discussion Leader: Emery Bresnick (Univ Wisconsin) |
9:00 am - 9:20 am | Ross Hardison (Penn State)
"Epigenomics and gene regulation: What do all those reads tell you?"
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9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Emery Bresnick (Univ Wisconsin)
"Epigenetic mechanisms underlying red cell development and hemoglobin synthesis"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Peng Ji (Northwestern Univ)
"Chromatin dynamics and histone H2A variants in erythropoiesis"
|
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Gerd Blobel (Univ Penn)
"Exploring long-range genomic interactions in the nucleus"
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11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Debbie Hay (Oxford)
"The patient Is always right: revisiting the globin gene enhancers"
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11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Merav Socolovsky (Univ Mass)
"Global DNA demethylation in erythropoiesis: mechanism and function"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Laurie Steiner (Univ Rochester)
"Beta Yac ESREs: A novel model system for studying the role of LSD1 in globin switching and terminal erythroid maturation"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transcriptional Regulation of Erythroid Gene Expression |
| Discussion Leader: Gerd Blobel (Univ Penn) |
7:30 pm - 7:50 pm | Stuart Orkin (Harvard)
"Control of globin switching"
|
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Andrew Perkins (Univ Queensland)
"KLF1 in health and disease"
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8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Jim Bieker (Mt. Sinai)
"Control of red blood cell maturation by EKLF/KLF1"
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8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Guillaume Giraud (Erasmus)
"Transcriptional control of erythropoiesis"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from GRS: Deepti Jain (Penn State)
"Genome-wide GATA1 binding kinetics distinguish erythroid induction versus repression of megakaryocytic genes during differentiation"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Erythropoiesis and Red Cell Production |
| Discussion Leader: Lionel Blanc (Feinstein) |
9:00 am - 9:20 am | Harvey Lodish (MIT)
"Self-renewal of erythroid progenitor cells: molecular mechanisms and new therapeutics for anemias"
|
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Don Wojchowski (Maine Medical Center)
"Novel mediators of EPO-dependent murine vs human erythropoiesis"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Bob Paulson (Penn State)
"Regulation of stress erythropoiesis by interactions between stress erythroid progenitors and the microenvironment"
|
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Stefano Rivella (Cornell)
"Iron-independent stress erythropoiesis macrophage activity (SEMA)"
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11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Paul Frenette (Albert Einstein)
"Macrophage function in erythropoiesis"
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11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Mario Falchi (Instituto Superiore di Sanita)
"The making of erythroid islands in HEMA culture"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Luc Douay (Univ M. Curie)
"In vitro terminal maturation of erythroid pathway: perspectives for transfusion medicine" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Membrane Protein Structures and Functions |
| Discussion Leader: Velia Fowler (Scripps) |
7:30 pm - 7:50 pm | Phil Low (Purdue Univ)
"Regulation of erythrocyte function by oxygen and tyrosine kinases"
|
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Athar Chishti (Tufts Univ)
"Stability of the erythrocyte membrane"
|
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Lesley Bruce and Veronique Picard (Univ Bristol)
"The expression of homozygous South East Asian ovalocytic band 3 through erythropoiesis"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | David Speicher (Wistar Institute)
"Unexpected red cell membrane skeletal components and interactions"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from GRS: YuShan Huang (University of Rochester)
"Circulating primitive erythroblasts assemble a cytoskeletal network at late stages of maturation"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Erythropoiesis |
| Discussion Leader: Merav Socolovsky (Univ Mass) |
9:00 am - 9:20 am | Dennis Discher (Univ Penn)
"Nuclear lamin regulation of cell fates"
|
9:20 am - 9:25 am | Discussion |
9:25 am - 9:40 am | Leal Oburoglou (Montpellier)
"Metabolic control of erythroid differentiation"
|
9:40 am - 9:45 am | Discussion |
9:45 am - 10:05 am | Saghi Ghaffari (Mt. Sinai)
"Metabolic regulation of terminal erythroid cell maturation"
|
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | John Conboy (Berkeley Lab)
"A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis"
|
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Mitch Weiss (Children's Hospital of Philadelphia)
"Trim38 functions in late-stage erythropoiesis"
|
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Theodosia Kalfa (Cincinnati Childrens)
"RhoA GTPase in terminal erythroid maturation"
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11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Velia Fowler (Scripps)
"Cytoskeletal rearrangements in erythroblast enucleation"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Iron, Heme and the Red Cell |
| Discussion Leader: Barry Paw (Harvard) |
7:30 pm - 7:50 pm | Iqbal Hamza (Univ Maryland)
"Heme transport and trafficking: lessons from bloodless worms"
|
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Jan Abkowitz (Univ Washington)
"The coordinate regulation of heme and globin during early red cell maturation"
|
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Yvette Yien and Jacky Chung (Harvard)
"Tmem14c as a novel regulator of porphyrin trafficking / Lat3, a leucine transporter required for red cell development"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Tom Ganz (UCLA)
"Erythroferrone, an erythroid regulator of hepcidin and iron"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Selected from GRS: Vikram Paralkar (University of Penn)
"Long noncoding RNAs in erythropoiesis"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Red Cell Disorders I |
| Discussion Leader: Vijay Sankaran (Harvard) |
9:00 am - 9:20 am | David Bodine (NIH)
"Mutation detection in Diamond Blackfan Anemia"
|
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Vijay Sankaran (Harvard)
"New Insight into the pathogenesis of Diamond-Blackfan anemia"
|
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Adrianna Vlachos (Feinstein Institute)
"Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q- syndrome"
|
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Lily Huang (UT Southwestern)
"Three activating JAK2 mutants differentially drive proliferation and differentiation of myeloid and erythroid progenitors to cause distinct myeloproliferative neoplasms"
|
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Pat Gallagher (Yale)
"PIEZO1 in erythroid cells" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Yves Colin (Univ Paris)
"Cell adhesion in SCD and new tools for prognosis and management" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Yelena Ginzburg (NY Blood Center)
"Exploring the definition of ineffective erythropoiesis in beta-thalassemia"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Red Cell Disorders II - Infections |
| Discussion Leader: Cheryl Lobo (New York Blood Center) |
7:30 pm - 7:50 pm | Sourik Bhattacharjee (Notre Dame)
"Remodeling the host by malaria parasites"
|
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Ian Lewis (Princeton)
"High resolution peptidomics links drug resistance to impaired hemoglobin metabolism in Plasmodium falciparum"
|
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Akhil Vaidya (Drexel)
"Plasma membrane reorganization in response to newly discovered antimalarials"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Cheryl Lobo (New York Blood Center)
"Babesia and the red cell"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Selected from GRS: Jiahai Shi (MIT)
"Jak2-V617F enhances red cell production by triggering CFU-E self-renewal"
|
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |