Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Developmental Biology of Erythropoiesis |
| Discussion Leader: James Palis (University of Rochester, USA) |
7:40 pm - 8:05 pm | James Palis (University of Rochester, USA) "Embryonic Erythropoiesis - Emergence and Self-Renewal Potential" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Momoko Yoshimoto (Indiana University, USA) "Evidence that Some Blood Cells Formed Prior to HSC Emergence During Development Possess Self-Renewal Properties" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Florent Ginhoux (Singapore Immunology Network, Singapore) "Ontogeny of Tissue-Resident Macrophages: Embryonic Versus Adult Contribution" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Virginie Esain (Harvard Medical School / Beth Israel Deaconess Medical Center, USA) "Inflammatory Regulation of Hematopoietic Stem Cell Formation and Function" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Epigenetics and Chromatin Modification |
| Discussion Leader: Patrick Gallagher (Yale University School of Medicine, USA) |
9:00 am - 9:25 am | Patrick Gallagher (Yale University School of Medicine, USA) "Genetics and Epigenetics of Erythrocyte Volume Homeostasis" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Andrew DeVilbiss (University of Wisconsin, Madison, USA) "Epigenetic Mechanisms Governing Erythroid Cell Development and Function" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:15 am | Mira Kassouf (Weatherall Institute of Molecular Medicine, United Kingdom) "Inversion of the Alpha Globin Regulatory Elements Disrupts the Natural Landscape and Affects Gene Expression" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Laurie Steiner (University of Rochester, USA) "The Role of the Histone Methyltransferase Setd8 in Eythropoiesis" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Jennifer Trowbridge (The Jackson Laboratory, USA) "Epigenetic Control of Hematopoietic Progenitor Cell Fate" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Stuart Orkin (Harvard University, USA) "Control of HbF by BCL11A" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Daniel Bauer (Harvard Medical School, USA) "Functional BCL11A Enhancer Dissection by In Situ Cas9 Saturation Editing" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Transcriptional Control of Erythropoiesis |
| Discussion Leader: Andrew Perkins (University of Queensland, Australia) |
7:30 pm - 7:55 pm | Andrew Perkins (University of Queensland, Australia) "Erythroid Gene Regulation by KLF1 in Health and Disease" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | James Bieker (Mount Sinai School of Medicine, USA) "Erythroid Transcriptional Control by KLF1/EKLF" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Gerd Blobel (University of Pennsylvania, USA) "Maintaining Transcriptional Patterns Through Mitosis" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Ross Hardison (Pennsylvania State University, USA) "Insights into Hematopoiesis via Comparative Functional Genomics" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Satish Nandakumar (Boston Children's Hospital, USA) "Systematic Genetic Dissection of Common Human Variation in Red Blood Cell Traits" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Erythropoiesis and Red Cell Production |
| Discussion Leader: Mohandas Narla (New York Blood Center, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader: Erythropoiesis: New Insights and Challenges |
9:05 am - 9:25 am | Xuili An (New York Blood Center, USA) "TET in Human Erythropoiesis" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sandrina Kinet (Institute de Genetique Moleculaire de Montpellier, France) "Metabolic Control of Erythroid Differentiation" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:15 am | Sherry Lee (Whitehead Institute for Biomedical Research, USA) "Self-Renewal of Human BFU-E Erythroid Progenitor Cells: From the Clinic to the Laboratory and Back to the Clinic" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | John Crispino (Northwestern University, USA) "Stage Specific Requirements for GATA1 in Erythropoiesis" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Lionel Blanc (The Feinstein Institute for Medical Research, USA) "Regulation of Human Erythropoiesis by Pomalidomide" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Olivier Hermine (Paris-Sorbonne University Imagine Institute, France) "New Insights in Thalassemia Ineffective Erythropoiesis" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Don Wojchowski (Maine Medical Center Research Institute, USA) "Novel Mediators of EPO-Dependent Erythropoiesis (As Discovered via Phosphoproteomics)" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Erythropoiesis: Terminal Erythroid
Maturation |
| Discussion Leader: Theodosia Kalfa (Cincinnati Children's Hospital Medical Center, USA) |
7:30 pm - 7:55 pm | Theodosia Kalfa (Cincinnati Children's Hospital Medical Center, USA) "Rho GTPases in Erythroblastic Islands" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Saghi Ghaffari (Icahn School of Medicine at Mount Sinai, USA) "FOXO3 Regulation of Terminal Erythroid Maturation" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:45 pm | Merav Socolovsky (University of Massachusetts Medical School, USA) "Reprogramming of S Phase During an Erythroid Cell Fate Decision" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | John Conboy (Lawrence Berkeley National Laboratory, USA) "A Stage-Specific Intron Retention Program Regulates Expression of Important Genes During Terminal Erythropoiesis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Yung Hwang (University of Massachusetts Medical School, USA) "Reprograming of S Phase at the Switch from Self-Renewal to Differentiation in Erythroid CFUe Progenitors Is Regulated by the Cyclin-Dependent-Kinase Inhibitor (CDKI) p57KIP2" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Iron, Heme and the Red Cell |
| Discussion Leader: Nancy Andrews (Duke University, USA) |
9:00 am - 9:20 am | Nancy Andrews (Duke University, USA) "Ironing Out Roles of the Transferrin Receptor In Vivo" |
9:20 am - 9:25 am | Discussion |
9:25 am - 9:45 am | Janis Abkowitz (University of Washington, USA) "The Coordination of Heme with Globin During Eythropoiesis" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Jodie Babitt (Massachusetts General Hospital / Harvard Medical School, USA) "Hepcidin Regulation in the Anemia of Inflammation" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Caroline Philpott (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) "PCBPs and NCOA4 Control the Flux of Iron Through Ferritin in Developing Erythroid Cells" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Caroline Enns (Oregon Health and Science University, USA) "A Role for Transferrin Receptor 2 in Erythropoiesis" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Huihui Li (New York Blood Center, USA) "Regulatory Role of Iron Transport in Ineffective Erythropoiesis" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Yvette Yien (Brigham and Women's Hospital / Harvard Medical School, USA) "Fam210b Regulates Cellular Iron Uptake and Heme Synthesis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jacky Chung (Brigham and Women's Hospital / Harvard Medical School, USA) "Heme Biosynthesis in Red Cells Is Regulated by Phosphorylation of Ferrochelatase in Its Catalytic Domain" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Membrane Protein Structure and Function |
| Discussion Leader: Velia Fowler (The Scripps Research Institute, USA) |
7:30 pm - 7:40 pm | Elizabeth Macari (Boston Children's Hospital, USA) "Calmodulin Inhibition Rescues the Effects of Ribosomal Protein Deficiency in Diamond Blackfan Anemia Models" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 8:05 pm | Velia Fowler (The Scripps Research Institute, USA) "Novel Actomyosin Mechanisms Regulating Red Blood Cell Shape and Physiology" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Philip Low (Purdue University, USA) "Regulation of Ankyrin-Band 3 Interactions in Healthy and Diseased Red Cells" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Jon Morow (Yale University, USA) "Spectrin-Dependent Protein Sorting During Hematopoiesis" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Samuel Lux (Boston Children's Hospital, USA) "Dissecting the Membrane Skeleton: Lots of Anatomy Left to Discover" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Red Cell Disorders |
| Discussion Leader: David Bodine (National Human Genome Research Institute, NIH, USA) |
9:00 am - 9:25 am | David Bodine (National Human Genome Research Institute, NIH, USA) "Analysis of Erythroid Cells Cultured from Diamond Blackfan Anemia Patients" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Jeffrey Lipton (Cohen Children's Medical Center of New York, USA) "The Diamond Blackfan Anemia Registry (DBAR): Providing the Substrate for 'Translational' Medicine" |
9:50 am - 9:55 am | Discussion |
9:55 am - 10:15 am | Vijay Sankaran (Boston Children's Hospital, USA) "Limiting Ribosome Availability Impairs Human Erythropoiesis" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Michaela Fontenay (INSERM, France) "Ribosome Biogenesis in Normal and Pathological Erythropoiesis" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Len Zon (Boston Children's Hospital, USA) "Finding New Therapies for Diamond Blackfan Anemia" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Stefano Rivella (Weill Cornell Medical College, USA) "Forced Chromatin Looping Increases Fetal Globin Expression to Curative Levels in Sickle Cell Anemia" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:25 pm | Yuichi Takakuwa (Tokyo Women's Medical University, Japan) "Maintenance, Regulation and Disorder of Asymmetric Distribution of Phospholipids in the Bilayer of Human Erythrocyte Membranes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Red Cell Disorders: Infections |
| Discussion Leader: Cheryl Lobo (Lindsley Kimball Research Institute, USA) |
7:30 pm - 7:40 pm | Novalia Pishesha (Whitehead Institute for Biomedical Research / Massachusetts Institute of Technology, USA) "Antigen-Decorated Engineered Red Blood Cells as a Novel Immune Tolerance-Inducing Agent" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 8:05 pm | Cheryl Lobo (Lindsley Kimball Research Institute, USA) "Babesia and Its Interaction with the RBC" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Chetan Chitnis (Pasteur Institute, France) "Entry and Exit from Red Cells by Malaria Parasites" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Niraj Tolia (Washington University in St. Louis School of Medicine, USA) "Red Cell Membrane Proteins as Access Points for Malaria Invasion" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Morgan Goheen (University of North Carolina at Chapel Hill, USA) "RBCs, Host Iron Status and Malaria Pathogenesis" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |