Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Developmental Biology of Erythropoiesis
Discussion Leader: Gordon Keller (McEwen Centre for Regenerative Medicine, Canada)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:00 pm
James Palis (University of Rochester Medical Center, USA)
"Emergence of Definitive Hematopoiesis from Erythro-Myeloid Progenitors in the Mammalian Yolk Sac"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
Andrea Ditadi (San Raffaele Telethon Institute for Gene Therapy, Italy)
"A View of Human Hematopoietic Development and Disease from the Petri Dish"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Stella Chou (Children's Hospital of Philadelphia, USA)
"iPS Cells for the Blood Bank"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:25 pm
Richard Myers (HudsonAlpha Institute for Biotechnology, USA)
"Globins and Global Gene Regulation: A Journey from Basic Research to Biomedical Applications"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Developmental Biology of Erythropoiesis / Erythroid Transcription: Lineage Specific Transcription Factors
Discussion Leader: Gerd Blobel (Children's Hospital of Philadelphia, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Leonard Zon (Howard Hughes Medical Institute / Boston Children's Hospital, USA)
"Induction of Hematopoiesis During Zebrafish Development"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Bryan Venters (Vanderbilt University, USA)
"Transcriptional Control by Epo in Terminal Erythroid Differentiation"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Laurie Steiner (University of Rochester School of Medicine, USA)
"Insights into the Function of Setd8 and H4K20 Monomethylation in Terminal Erythroid Maturation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Ross Hardison (Pennsylvania State University, USA)
"Validated Systematic Integration: A VISION for Epigenomics in Hematopoietic Gene
Regulation"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Bertie Gottgens (University of Cambridge, United Kingdom)
"Regulatory Network Control of Blood Cell Development"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Andrew Perkins (Monash University, Australia)
"Interactions Between EPO Signals, GATA1 and KLF1 in the Erythroid Cell Nucleus"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Jason Buenrostro (Broad Institute, USA)
"From Ensembles to Single-Cells: A Window into Cis- and Trans- Epigenomic Variation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Saghi Ghaffari (Icahn School of Medicine at Mount Sinai, USA)
"FOXO3, Mitochondria and Regulation of Terminal Erythropoiesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Vivien Sheehan (Baylor College of Medicine, USA)
"Regulation of Fetal Hemoglobin Production by FOXO3"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Erythroid Transcription: Chromatin
Discussion Leader: Ross Hardison (Pennsylvania State University, USA)
7:30 pm - 7:45 pm
Stuart Orkin (Harvard University, USA)
"HbF: Silencing and Approaches to Reactivate Expression in the Adult"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Emery Bresnick (University of Wisconsin School of Medicine and Public Health, USA)
"Deciphering the Hematopoietic Stem/Progenitor Cell Cistrome"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Jian Xu (University of Texas Southwestern Medical Center, USA)
"CAPTURE the Erythroid Epigenome"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Gerd Blobel (Children's Hospital of Philadelphia, USA)
"Chromatin Architecture in Erythroid Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Jim Hughes (University of Oxford, United Kingdom)
"Gene Regulation and Mutation in the 3-Dimensional Nucleus"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Mira Kassouf (Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom)
"Enhancer Orientation and Transcriptional Regulation"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms of Erythropoiesis: Lineage
Commitment and Expansion
Discussion Leader: Naomi Taylor (Laboratory of Excellence GR-Ex / Institute of Molecular Genetics of Montpellier, France)
9:00 am - 9:15 am
Vijay Sankaran (Boston Children's Hospital / Harvard Medical School, USA)
"Genetic Insights into Human Erythropoiesis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Merav Socolovsky (University of Massachusetts Medical School, USA)
"Early Erythropoiesis Through the Lens of Single-Cell Transcriptomics"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Mohandas Narla (New York Blood Center, USA)
"New Insights into Erythroid Progenitors"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jim Bieker (Icahn School of Medicine at Mount Sinai, USA)
"Altered Function of Mutant KLF1/EKLF in Erythropoietic Onset"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Luanne Peters (The Jackson Laboratory, USA)
"Requirement for RASA3 in Blood Formation: Studies in scat and Rasa3 cKO Models"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Lily Huang (University of Texas Southwestern Medical Center, USA)
"Coupling Differences to Epo and G-CSF Receptors Dictates Outcomes of Activating JAK2 Mutants in Myeloproliferative Neoplasm"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
Allon Klein (Harvard Medical School, USA)
"Emergence of the Erythroid Fate from the Early Hematopoietic Hierarchy: A Single Cell RNA-Seq Approach"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Marjorie Brand (Ottawa Hospital Research Institute, Canada)
"Quantitative Mass Spectrometry and Single-Cell Mass Cytometry to Model Erythropoiesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Annamaria Aprile (San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Italy)
"Beta-Thalassemia Beyond the Erythropoietic Defect: Impaired Self-Renewal of Hematopoietic Stem Cell Within an Altered Bone Marrow Niche"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Erythropoiesis: Terminal Maturation
Discussion Leader: Merav Socolovsky (University of Massachusetts Medical School, USA)
7:30 pm - 7:45 pm
Daniel Finley (Harvard Medical School, USA)
"Remodeling of the Proteome in Reticulocytes"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Naomi Taylor (Laboratory of Excellence GR-Ex / Institute of Molecular Genetics of Montpellier, France)
"Nutrient Regulation of HSC Differentiation, Red Cell Style"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Peng Ji (Northwestern University, USA)
"Nuclear Opening and Histone Release During Chromatin Condensation in Terminal Erythropoiesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Harvey Lodish (Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, USA)
"Regulating Self-Renewal of BFU-E Progenitors - Repurposed Drugs for Epo-Resistant Anemias"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Theodosia Kalfa (Cincinnati Children's Hospital Medical Center, USA)
"Exploring Intercellular Interactions Within Erythroblastic Islands"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Kyle Hewitt (University of Wisconsin-Madison, USA)
"GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heme and Iron
Discussion Leader: Elizabeta Nemeth (University of California, Los Angeles, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Tomas Ganz (University of California, Los Angeles, USA)
"Hepcidin Contributes to Host Defense Against Gram-Negative Infections by Controlling Non-Transferrin-Bound Iron"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Caroline Philpott (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Iron Flux Through Ferritin During Erythrocyte Development"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Barry Paw (Brigham and Women's Hospital / Harvard Medical School, USA)
"A Dominant Mutation in Mitochondrial Unfoldase CLPX Contributes to Erythropoietic Protoporphyria"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Tracey Rouault (National Institute of Child Health and Human Development, NIH, USA)
"Unexpected Role of Ferroportin in Survival of Mature Red Cells and Protection from Malarial Infection"
10:20 am - 10:25 am
Discussion
10:25 am - 10:40 am
Jane-Jane Chen (Massachusetts Institute of Technology, USA)
"Integrated Stress Response of Heme-Regulated eIF2alpha Kinase in Erythropoiesis"
10:40 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:30 am
Jodie Babitt (Massachusetts General Hospital / Harvard Medical School, USA)
"Liver Endothelial Cells in Iron Sensing and Hepcidin Regulation"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Janis Abkowitz (University of Washington, USA)
"Heme Signaling and Diamond Blackfan Anemia"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
David Bodine (National Human Genome Research Institute, NIH, USA)
"Diamond Blackfan Anemia: Many Ways for Erythropoiesis to Fail"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Avik Choudhuri (Harvard University, USA)
"Signaling Centers Define Stages of Human Erythropoiesis and Harbor Common Variants of Red Blood Cell Traits"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Structure and Function
Discussion Leader: Philip Low (Purdue University, USA)
7:30 pm - 7:45 pm
Reinhart Reithmeier (University of Toronto, Canada)
"Band 3 Function and Dysfunction in a Structural Context"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Vann Bennett (Duke University School of Medicine, USA)
"Ankyrin-B Metabolic Syndrome: A New Cell-Autonomous Mechanism for Obesity with Public Health Implications"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Haiyan Chu (Endocyte Inc, USA)
"Mechanism of O2 Regulation of Red Cell Properties"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Velia Fowler (The Scripps Research Institute, USA)
"Erythroblast Enucleation Depends upon F-Actin Regulation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Emilie-Fleur Gautier (Laboratory of Excellence GR-Ex / 3P5 Proteomic Facility, Paris Descartes University, France)
"Proteomic Study of Erythroid Differentiation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Dennis Discher (University of Pennsylvania, USA)
"Marker of Self CD47 Structure-Function in Relation Blockade "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Red Cell Disorders: Genetics, Mechanisms and Innovative
Treatments
Discussion Leaders: Vijay Sankaran (Boston Children's Hospital / Harvard Medical School, USA) and Caroline Le Van Kim (Laboratory of Excellence GR-Ex / Institut National de la Transfusion Sanguine (INTS), INSERM U665, France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
Lydie Da Costa (Laboratory of Excellence GR-Ex / INSERM U1134, France)
"HSP70, One of the Major Key Factors in Diamond-Blackfan Anemia Pathophysiology"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
Mark Dewitt (Innovative Genomics Institute, University of California, Berkeley, USA)
"Gene Editing to Ameliorate Globinopathies"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Robert Paulson (Pennsylvania State University, USA)
"Induction of Stress Erythropoiesis by Inflammation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
Lionel Blanc (The Feinstein Institute for Medical Research, USA)
"Pomalidomide and Dexamethasone and Their Effects on Erythropoiesis"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
Peter Glazer (Yale University, USA)
"In Vivo Gene Editing for Hemoglobin Disorders via PNA Nanoparticles"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
Olivier Hermine (Laboratory of Excellence GR-Ex / Paris-Sorbonne University / Imagine Institute, France)
"New Molecular Insights that Determine the Control of Apoptosis Versus Differentiation in Normal and Pathological Erythropoiesis: Potential Therapeutic Implications"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
Jane Little (Case Western Reserve University, USA)
"The SCD Biochip: Measuring Abnormal RBC Adhesion During Day-to-Day Clinical Care"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Jiandi Wan (Rochester Institute of Technology, USA)
"PO2 Regulated Red Blood Cell (RBC) Deformation in Capillary Flow"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Natasha Archer (Boston Children's Hospital, USA)
"Sickle Hemoglobin Polymerization During Hypoxic Sequestration Hinders Plasmodium falciparum Growth"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Red Cell Disorders: Infections
Discussion Leader: Kasturi Haldar (University of Notre Dame, USA)
7:30 pm - 7:45 pm
Catherine Lavazec (Laboratory of Excellence GR-Ex / Institut Cochin, INSERM, France)
"Targeting Erythrocyte Deformability to Block Malaria Parasite Transmission"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Manoj Duraisingh (Harvard T.H. Chan School of Public Health, USA)
"Targeting Red Blood Cell Determinants of Malaria Infection"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Bruce Russell (University of Otago, New Zealand)
"New Insights on How Malaria Parasites Target Reticulocytes and Modify Them Post Invasion"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Gavin Wright (Wellcome Trust Sanger Institute, United Kingdom)
"Systematic Extracellular Receptor Interaction Screens to Determine the Molecular Basis of Erythrocyte Invasion by Plasmodium Parasites"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Joshua Denny (University of Louisville, USA)
"Crosstalk Between the Gut Microbiota and Blood Stage Malaria"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Jianbing Zhang (University of Maryland, USA)
"Functional Characterization of Hrg1 in Zebrafish"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Merlin Nithya Gnanapragasam (Icahn School of Medicine at Mount Sinai, USA)
"Delineating the Functions of EKLF During Erythroid Terminal Differentiation"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure