Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Developmental Erythropoiesis
7:40 pm - 8:00 pm
"TIF1γ Transcriptionally Regulates Mitochondrial Metabolic Pathways to Drive Erythropoiesis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Regulation of Definitive Erythroid Progenitor Development by the Vitamin D Receptor Transcription Factor"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Single Cell Approaches to Study Normal and Failed Hematopoiesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Transcriptional Signaling Centers During Human Erythropoiesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics of Erythropoiesis
9:00 am - 9:20 am
"Epigenetic Regulation of Erythroid Gene Expression"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"New Insights into Gene Regulation Based on Multi-Way Chromatin Interactions at Single Alleles"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Activated Erythroid Gene Expression by Ubiquitin-Mediated Proteolysis of a Transcriptional Repressor at Bivalent Chromatin"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Mechanisms by Which Enhancers Promote Transcription at the Globin Loci"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Multiplexed CAPTURE of the Dynamic 3D Epigenome During Erythropoiesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New Insights into the Regulation of Gene Expression by the GATA1s Isoform"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mass Spectrometry for Histone Posttranslational Modifications Reveals Novel Insights into Terminal Erythroid Maturation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Infectious Diseases of the Erythrocyte
7:30 pm - 7:50 pm
"Vesicle-Mediated Antigen Export in Babesia Microti-Infected Erythrocytes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Protection Against Severe Malaria: Red Blood Cell Tension, Plasmodium falciparum Invasion and Rare Glycophorin Variants"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"A New Therapy for Malaria: Mechanism and Early Clinical Results"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Determinants of Plasmodium falciparum Infection"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Dissecting the Mechanisms of Malaria Induced Anemia in Rodent Malaria Models"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Erythrocyte Disorders: Inherited and Acquired
9:00 am - 9:20 am
"Diamond Blackfan Anemia: Big Lessons from a Small Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Regulation of Globin-Heme Balance in Diamond-Blackfan Anemia by HSP70/GATA1"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Piecing Together the Impact of Aberrant Splicing on Terminal Erythroid Maturation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Hydroxyurea: How to Teach an Old Drug New Tricks"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Targeting Epigenetic Repressor Subunit Inactivation to Treat SCD"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"The Congenital Dyserythropoietic Anemias: From Basic Biology to Novel Therapeutic Strategies"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"MMS22L: A Novel Key Actor in Erythropoiesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Iron and Heme Homeostasis
7:30 pm - 7:40 pm
"Hemozoin Produced by Mammals Confers Heme Tolerance"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Regulation of Erythroid Heme Synthesis by the Mitochondrial Protein Unfoldase, CLPX"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Congenital Sideroblastic Anemia: Iron and Heme Lost in Mitochondrial Translation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Unexpectedly Important Role of Ferroportin Mediated Iron Export in Mature Red Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"New Mechanisms Regulating Iron Homeostasis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Erythropoiesis: Normal and Perturbed
9:00 am - 9:20 am
"A Congenital Hemolytic Anemia Dissociates the Pleiotropic Functions of a Master Transcription Factor"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Novel Function of MAEA (Erythroblast-Macrophage Protein) in Hematopoiesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Erythroblastic Island Macrophages: Identification and Functional Insights"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"A Systems Approach to Identification of Cells in Erythro(myelo)blastic Islands"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"New Insights into Human Erythroid Progenitors"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"RASA3 Regulates Specific Patterns of Ras Signaling During Erythropoiesis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"From Red Cells to White Cells and Back Again"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Disorders of the Erythrocyte and Emerging Therapeutics
7:30 pm - 7:50 pm
"Hemoglobin Switching via BCL11A"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"BCL11A as Target in Gene Therapy for Sickle Cell Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"A Modified Gamma-Globin Gene and Reduced Intensity Conditioning Ameliorates Sickle Cell Disease"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Mechanism of Action of Mitapivat (AG-348) in Hematological Disease"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Splenic Filtration of Storage-Induced Micro-Erythrocytes and Improvement of Transfusion Safety and Efficacy"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gene Regulation in Erythroid Development and Differentiation
9:00 am - 9:20 am
"Comprehensive Integrated Genomic Perturbation to Investigate Molecular Mechanisms of RBC Trait Associations"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Elucidating Mechanisms Governing Progenitor Cell Fate and Erythrocyte Generation Through Multiomics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Cell Cycle Specializations that Drive Early Erythroid Cell Fate Decisions: A Single-Cell Approach"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Regulation of Stress Erythropoiesis by Gdf15"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Delineating the Functions of EKLF During Terminal Erythroid Cell Divisions"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Epigenomic Analysis of KLF1 Haploinsufficiency in Primary Human Erythroblasts"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"KLF1 Pioneers for GATA1 and Associated Complexes at Key Erythroid Enhancers to Drive Red Blood Cell Differentiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Erythrocyte Membrane and Metabolism
7:30 pm - 7:40 pm
"Metabolism and Erythroid Differentiation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
"Metabolic Reprogramming Promotes Erythroid vs Myeloid Commitment Under Stress"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"mDia2 Modulates Cytoskeleton and Cytoplasmic Clearance During the Genesis of Reticulocyte"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"The Emerging Roles of Erythrocytes in the Regulation of Blood Flow in Microvessels"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Investigating the Impact of Deformation and Shear Stress on Erythroid Cells"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure