Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Developmental Erythropoiesis
Discussion Leader: James Palis (University of Rochester Medical Center, USA)
7:40 pm - 8:00 pm
Marlies Rossmann (Harvard University, USA)
"TIF1γ Transcriptionally Regulates Mitochondrial Metabolic Pathways to Drive Erythropoiesis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Margaret Baron (Icahn School of Medicine at Mount Sinai, USA)
"Regulation of Definitive Erythroid Progenitor Development by the Vitamin D Receptor Transcription Factor"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
David Bodine (National Human Genome Research Institute, NIH, USA)
"Single Cell Approaches to Study Normal and Failed Hematopoiesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Leonard Zon (Howard Hughes Medical Institute / Boston Children's Hospital, USA)
"Transcriptional Signaling Centers During Human Erythropoiesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetics of Erythropoiesis
Discussion Leader: Ann Dean (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
9:00 am - 9:20 am
Gerd Blobel (Children's Hospital of Philadelphia, USA)
"Epigenetic Regulation of Erythroid Gene Expression"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Marieke Oudelaar (University of Oxford, United Kingdom)
"New Insights into Gene Regulation Based on Multi-Way Chromatin Interactions at Single Alleles"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Mitchell Weiss (St. Jude Children's Research Hospital, USA)
"Activated Erythroid Gene Expression by Ubiquitin-Mediated Proteolysis of a Transcriptional Repressor at Bivalent Chromatin"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Martin Larke (University of Oxford, United Kingdom)
"The Mechanisms by Which Enhancers Promote Transcription at the Globin Loci"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jian Xu (University of Texas Southwestern Medical Center, USA)
"Multiplexed CAPTURE of the Dynamic 3D Epigenome During Erythropoiesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
John Crispino (Northwestern University, USA)
"New Insights into the Regulation of Gene Expression by the GATA1s Isoform"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Laurie Steiner (University of Rochester School of Medicine, USA)
"Mass Spectrometry for Histone Posttranslational Modifications Reveals Novel Insights into Terminal Erythroid Maturation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Caroline Le Van Kim (INSERM, France) and Punam Malik (Cincinnati Children's Hospital Medical Center, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Infectious Diseases of the Erythrocyte
Discussion Leader: Manoj Duraisingh (Harvard T.H. Chan School of Public Health, USA)
7:30 pm - 7:50 pm
Choukri Ben Mamoun (Yale University School of Medicine, USA)
"Vesicle-Mediated Antigen Export in Babesia Microti-Infected Erythrocytes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Julian Rayner (Wellcome Sanger Institute, United Kingdom)
"Protection Against Severe Malaria: Red Blood Cell Tension, Plasmodium falciparum Invasion and Rare Glycophorin Variants"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Philip Low (Purdue University, USA)
"A New Therapy for Malaria: Mechanism and Early Clinical Results"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Elizabeth Egan (Stanford University School of Medicine, USA)
"Determinants of Plasmodium falciparum Infection"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Keyla Tumas (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Dissecting the Mechanisms of Malaria Induced Anemia in Rodent Malaria Models"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Erythrocyte Disorders: Inherited and Acquired
Discussion Leaders: Jeffrey Lipton (Feinstein Institute for Medical Research, USA) and Alyson MacInnes (Amsterdam University Medical Center, The Netherlands)
9:00 am - 9:20 am
Adrianna Vlachos (The Feinstein Institute for Medical Research, USA)
"Diamond Blackfan Anemia: Big Lessons from a Small Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Lydie Da Costa (Robert Debré Hospital, France)
"Regulation of Globin-Heme Balance in Diamond-Blackfan Anemia by HSP70/GATA1"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Esther Obeng (St. Jude Children's Research Hospital, USA)
"Piecing Together the Impact of Aberrant Splicing on Terminal Erythroid Maturation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Russell Ware (Cincinnati Children's Hospital Medical Center, USA)
"Hydroxyurea: How to Teach an Old Drug New Tricks"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
James Engel (University of Michigan Medical School, USA)
"Targeting Epigenetic Repressor Subunit Inactivation to Treat SCD"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Rami Khoriaty (University of Michigan, USA)
"The Congenital Dyserythropoietic Anemias: From Basic Biology to Novel Therapeutic Strategies"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Elia Colin (Institut Imagine, France)
"MMS22L: A Novel Key Actor in Erythropoiesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Iron and Heme Homeostasis
Discussion Leaders: Caroline Enns (Oregon Health and Science University, USA) and Karin Finberg (Yale School of Medicine, USA)
7:30 pm - 7:40 pm
Rini Pek (University of Maryland, USA)
"Hemozoin Produced by Mammals Confers Heme Tolerance"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Yvette Yien (University of Delaware, USA)
"Regulation of Erythroid Heme Synthesis by the Mitochondrial Protein Unfoldase, CLPX"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sarah Ducamp (Boston Children's Hospital, USA)
"Congenital Sideroblastic Anemia: Iron and Heme Lost in Mitochondrial Translation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Tracey Rouault (National Institute of Child Health and Human Development, NIH, USA)
"The Unexpectedly Important Role of Ferroportin Mediated Iron Export in Mature Red Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Hal Drakesmith (University of Oxford, United Kingdom)
"New Mechanisms Regulating Iron Homeostasis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Erythropoiesis: Normal and Perturbed
Discussion Leaders: Theodosia Kalfa (Cincinnati Children's Hospital Medical Center, USA) and Lionel Blanc (The Feinstein Institute for Medical Research, USA)
9:00 am - 9:20 am
Vijay Sankaran (Boston Children's Hospital / Harvard Medical School, USA)
"A Congenital Hemolytic Anemia Dissociates the Pleiotropic Functions of a Master Transcription Factor"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Paul Frenette (Albert Einstein College of Medicine / Montefiore Medical Center, USA)
"Novel Function of MAEA (Erythroblast-Macrophage Protein) in Hematopoiesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Xiuli An (New York Blood Center, USA)
"Erythroblastic Island Macrophages: Identification and Functional Insights"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Katie Seu (Cincinnati Children's Hospital Medical Center, USA)
"A Systems Approach to Identification of Cells in Erythro(myelo)blastic Islands"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Hongxia Yan (New York Blood Center, USA)
"New Insights into Human Erythroid Progenitors"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Elena Brindley (Feinstein Institute for Medical Research, Zucker School of Medicine at Hofstra/Northwell, USA)
"RASA3 Regulates Specific Patterns of Ras Signaling During Erythropoiesis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Richard Flavell (Yale University / Howard Hughes Medical Institute, USA)
"From Red Cells to White Cells and Back Again"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Disorders of the Erythrocyte and Emerging Therapeutics
Discussion Leaders: Mitchell Weiss (St. Jude Children's Research Hospital, USA) and Anupama Narla (Stanford University School of Medicine, USA)
7:30 pm - 7:50 pm
Stuart Orkin (Harvard University, USA)
"Hemoglobin Switching via BCL11A"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
David Williams (Boston Children's Hospital, USA)
"BCL11A as Target in Gene Therapy for Sickle Cell Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Punam Malik (Cincinnati Children's Hospital Medical Center, USA)
"A Modified Gamma-Globin Gene and Reduced Intensity Conditioning Ameliorates Sickle Cell Disease"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Charles Kung (Agios Pharmaceuticals, USA)
"Mechanism of Action of Mitapivat (AG-348) in Hematological Disease"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Camille Roussel (Institut National de la Transfusion Sanguine (INTS), France)
"Splenic Filtration of Storage-Induced Micro-Erythrocytes and Improvement of Transfusion Safety and Efficacy"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gene Regulation in Erythroid Development and Differentiation
Discussion Leaders: James Bieker (Icahn School of Medicine at Mount Sinai, USA) and Eric Soler (Institute of Molecular Genetics of Montpellier (IGMM), France)
9:00 am - 9:20 am
Daniel Bauer (Boston Children's Hospital, USA)
"Comprehensive Integrated Genomic Perturbation to Investigate Molecular Mechanisms of RBC Trait Associations"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Emery Bresnick (University of Wisconsin School of Medicine and Public Health, USA)
"Elucidating Mechanisms Governing Progenitor Cell Fate and Erythrocyte Generation Through Multiomics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Merav Socolovsky (University of Massachusetts Medical School, USA)
"Cell Cycle Specializations that Drive Early Erythroid Cell Fate Decisions: A Single-Cell Approach"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Siyang Hao (The Pennsylvania State University, USA)
"Regulation of Stress Erythropoiesis by Gdf15"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Merlin Nithya Gnanapragasam (Icahn School of Medicine at Mount Sinai, USA)
"Delineating the Functions of EKLF During Terminal Erythroid Cell Divisions"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Emile Van Den Akker (Sanquin Research, The Netherlands)
"Epigenomic Analysis of KLF1 Haploinsufficiency in Primary Human Erythroblasts"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Andrew Perkins (Monash University, Australia)
"KLF1 Pioneers for GATA1 and Associated Complexes at Key Erythroid Enhancers to Drive Red Blood Cell Differentiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Erythrocyte Membrane and Metabolism
Discussion Leaders: Velia Fowler (University of Delaware, USA) and Sandrina Kinet (Institute of Molecular Genetics of Montpellier (IGMM), France)
7:30 pm - 7:40 pm
Pedro Gonzalez-Menendez (Institute of Molecular Genetics of Montpellier (IGMM), France)
"Metabolism and Erythroid Differentiation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
Yang Xia (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Metabolic Reprogramming Promotes Erythroid vs Myeloid Commitment Under Stress"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Peng Ji (Northwestern University, USA)
"mDia2 Modulates Cytoskeleton and Cytoplasmic Clearance During the Genesis of Reticulocyte"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Jiandi Wan (University of California, Davis, USA)
"The Emerging Roles of Erythrocytes in the Regulation of Blood Flow in Microvessels"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Pedro Moura (University of Bristol, United Kingdom)
"Investigating the Impact of Deformation and Shear Stress on Erythroid Cells"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure