Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Developmental Hematopoiesis and Stem Cells
Discussion Leaders: Irene Roberts (University of Oxford, United Kingdom) and James Palis (University of Rochester Medical Center, United States)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Leonard Zon (Boston Children's Hospital, United States)
"Keynote - Developmental Hematopoiesis"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Kyunghee Choi (Washington University School of Medicine, United States)
"ETV2 and Chromatin Remodeling in Hemangiogenic Fate Specification"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Leal Oburoglu (Lund Stem Cell Center, Lund University, Sweden)
"The Role of the Pentose Phosphate Pathway in Erythroid Cell Emergence"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Elisa Laurenti (University of Cambridge, United Kingdom)
"Human Haematopoietic Stem Cell Commitment to the Erythroid Lineage in Early Life"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Erythrocyte Cell Biology and Regulation of Homeostasis
Discussion Leaders: Olivier Hermine (Laboratory of Excellence GR-Ex / Paris-Sorbonne University / Imagine Institute, France) and Tracey Rouault (National Institute of Child Health and Human Development, NIH, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Patrick Gallagher (Yale University School of Medicine, United States)
"Examining Mechanisms of Reticulocyte Remodeling"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Arit Ghosh (University of Delaware, Newark, United States)
"Comprehensive Analysis of Actin-Binding Proteins in Terminal Erythroid Differentiation Reveals Tensin1 as a Novel Actin Regulator of Erythroblast Enucleation"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Elzbieta Pluskota (Cleveland Clinic , Lerner Research Institute, United States)
"Kindlin-3 Deficiency Results in Defective Erythropoiesis and Abnormal Erythrocyte Cytoskeleton."
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Yvette Yien (University of Pittsburgh, United States)
"Regulation of Erythroid Heme Synthesis by Mitochondrial Proteins"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Robin Van Bruggen (Sanquin, dept. of Molecular Hematology, The Netherlands)
"Hemolysis in the Spleen Drives Erythrocyte Turnover"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
Shang Ma (UT Southwestern, Dallas, United States)
"The Role of Overactive PIEZO1 in Hereditary Xerocytosis"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Hitoshi Takizawa (Kumamoto University, Japan)
"Mitochondrial Translation Drives Erythroid Differentiation via Iron Homeostasis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Isabel Dorn (Medical University Graz, Austria)
"Characterization of Emerging iPSC-Derived Hematopoiesis and Erythropoiesis Inside Three-Dimensional Cellular Complexes (Hemanoids)"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Maria Rosa Lidonnici (ST-Tiget, Ospedale San Raffaele , Italy)
"Erythroid-Biased Hematopoietic Stem Cell Fate is Shaped by the Disease in Beta-Thalassemia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Rebecca Clements (University of Pennsylvania, United States)
"Erythroid Progenitors: Unexpected Orchestrators of Fetal Immunity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Sandrina Kinet (Institute of Molecular Genetics of Montpellier (IGMM), France) and Velia Fowler (University of Delaware, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Single Cell Analysis in Erythropoiesis and Hematopoiesis
Discussion Leaders: Merav Socolovsky (University of Massachusetts Chan Medical School, United States) and Vince Schulz (Yale University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Janis Abkowitz (University of Washington, United States)
"Effective and Ineffective Human Erythropoiesis at Single Cell Resolution"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Leila Perié (institut curie, France)
"Family Matters: the Role of Single Cell Families in Hematopoiesis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Mitchell Weiss (St. Jude Children's Research Hospital, United States)
"MicroRNA Regulation of Alpha Globin Quality Control in Beta Thalassemia"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Hojun Li (Massachusetts Institute of Technology, United States)
"Dissecting Erythroid Lineage Commitment Over the Human Lifetime"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Allon Klein (Harvard Medical School, United States)
"Single Cell RNA-Seq Reconstruction of Erythropoietic Dynamics: Baseline, Stress, and Cytokine Responses"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Iron, Inflammation and Infection
Discussion Leaders: Hal Drakesmith (University of Oxford, United Kingdom) and Elizabeth Egan (Stanford University School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Philip Low (Purdue University, United States)
"Sickle Cell Disease and Malaria Share a Common Mechanism and Potential Therapy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Catherine Lavazec (Institut Cochin, CNRS, France)
"Plasmodium Falciparum Infection of Erythroid Cells"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Manoj Duraisingh (Harvard T.H. Chan School of Public Health, United States)
"Essential Red Blood Cell Determinants of Malaria Infection"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Lionel Blanc (The Feinstein Institutes for Medical Research, United States)
"Novel Regulators of Erythromyeloblastic Islands During Inflammation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Elizabeta Nemeth (UCLA, United States)
"Iron Deficiency Worsens Inflammatory Tissue Injury"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Stefano Rivella (Children's Hospital of Philadelphia, United States)
"Modulation of Normal and Ineffective Erythropoiesis by Monoferric Transferrins and TFR2"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Tomas Ganz (David Geffen School of Medicine at UCLA, United States)
"Hypoferremia of Inflammation and its Role in Antibacterial Host Defense"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Physiology of Normal and Perturbed Erythropoiesis
Discussion Leaders: Esther Obeng (St. Jude Children's Research Hospital, United States) and Marjorie Brand (Ottawa Hospital Research Institute, Canada)
7:30 pm - 7:50 pm
Jian Xu (University of Texas Southwestern Medical Center, United States)
"When Transcription Meets Metabolism in Red Cells"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Merlin Nithya Gnanapragasam (Cleveland State University, United States)
"Functional Characterization of KLF1 and its Targets During Terminal Erythroid Differentiation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Saghi Ghaffari (Icahn School of Medicine at Mount Sinai, United States)
"Mitochondria in Terminal Erythropoiesis"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Pedro Gonzalez-Menendez (Universidad de Oviedo, Spain)
"The Impact of Polyamine Biosynthesis in Normal and Ineffective Erythropoiesis"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Kaustav Mukherjee (Icahn School of Medicine at Mount Sinai, United States)
"Modeling CDA IV Associated Dyserythropoiesis Using Patient-Derived Stem and Progenitor Cells"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Christian Babbs (Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom)
"Genetic and Functional Insights into the Prevalence and Pathogenesis of Congenital Dyserythropoietic Anaemia Type I (CDA-I)"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Treatments and Therapeutics to Treat Erythroid Disorders
Discussion Leaders: Russell Ware (Cincinnati Children's Hospital Medical Center, United States) and Courtney Fitzhugh (NIH, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Merav Socolovsky (University of Massachusetts Chan Medical School, United States)
"Second Key Note: ‘The Shifting Shape of the Cell Cycle and It Impact on Lineage Differentiation’"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Charles Quinn (CCHMC, United States)
"Mechanisms of Current Therapies for Sickle Cell Disease"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Sara El Hoss (Red Cell Haematology Laboratory, School of Cancer & Pharmaceutical Sciences, King's College London, United Kingdom)
"Sickle Cell Disease: Ineffective Erythropoiesis, GATA1 and Hydroxyurea"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Adetola Kassim (Vanderbilt University Medical Center, United States)
"Curative Therapy for Sickle Cell Disease: Challenges and Pitfalls"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
Rachael Grace (Boston Children's Hospital, United States)
"PK Activators for Treatment of Pyruvate Kinase Deficiency and Other Hereditary Hemolytic Anemias"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Eszter Varga (Sanquin Reserach Amsterdam, The Netherlands)
"Transfusion-Ready Red Blood Cell Generation from Human Induced Pluripotent Stem Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Matthew Porteus (Stanford University, United States)
"Genome Editing of Hematopoietic Stem Cells to Engineer Red Blood Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Swee Lay Thein (National Heart, Lung and Blood Institute, NIH, United States)
"PKLR and Sickle Cell Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Congenital and Acquired Diseases of Erythrocytes
Discussion Leaders: Peng Ji (Northwestern University, United States) and Theodosia Kalfa (Cincinnati Children's Hospital Medical Center, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:50 pm
Katie Seu (Cincinnati Children's Hospital Medical Center, United States)
"Essential Functions of VPS4 and the ESCRT-III Machinery in Terminal Erythropoiesis"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
Slim Azouzi (CNRGS (EFS Île-de-France)/Inserm UMR S1134, France)
"Contribution of Null Blood Groups to the Identification of New Molecular Pathways for the Regulation of Erythropoiesis and New Treatments for Anemia"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Xiuli An (New York Blood Center, United States)
"JAK2 V617F Mutation in EpoR+ Macrophages Contributes to the Pathogenesis of Polycythemia Vera"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Gonzalo Hernandez (Universitat Internacional de Catalunya, Spain)
"RACGAP1, the Gene Responsible for Congenital Dyserythropoietic Anemia Type IIIB"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Auria Godard (Etablissement Français du Sang, France)
"Impact of Ineffective Erythropoiesis on the Erythroblastic Island in Sickle Cell Disease"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Lily Huang (University of Texas Southwestern Medical Center, United States)
"Mechanisms of Stress Erythropoiesis and Pathological Erythrocytosis in Myeloproliferative Neoplasm"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Novel Insights into Erythroid Genome Organization
Discussion Leaders: Marieke Oudelaar (Max Planck Institute for Multidisciplinary Sciences, Germany) and Ann Dean (NIH, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Vijay Sankaran (Boston Children's Hospital / Harvard Medical School, United States)
"Mapping Genetic Variation Impacting Fetal Hemoglobin and Human Erythropoiesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Vera Adema (MD Anderson Cancer Center, United States)
"Targeting the EIF2AK1 Signaling Pathway to Overcome Anemia in SF3B1 -mutant Myelodysplastic Syndromes with Ringed Sideroblasts"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Honghao Bi (Northwestern University, United States)
"DDX41 maintains the homeostasis of G-quadruplexes during erythropoiesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Yong Cheng (st. Jude Children's research hospital, United States)
"GATA1 Enhancers Balance the Distribution of Transcriptional Machinery Within the Same Chromatin Domain"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Marit Vermunt (Goethe University Frankfurt, Germany)
"Gene Silencing Dynamics During Erythroid Differentiation are Modulated by Transiently Active Regulatory Elements"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Rajesh Gunage (Boston Children's Hospital, United States)
"m6A Epitranscriptome Mediated RNA Stress Granule Assembly Governs Blood Development and Regeneration"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Areum Han (Boston Children's Hospital/Harvard Medical School, United States)
"The Role of the Zcchc6/Dis3L2 RNA Editor-Exonuclease Axis in Terminal Erythroid Differentiation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Alexandra Preston (University of Oxford, United Kingdom)
"A Conserved Transcriptional Hub Provides both Developmentally Regulated Gene Expression and Metabolic Control during Erythropoiesis"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Sherry Lee (Peking University, China)
"Deciphering Multidimensional Chromatin Reorganization Reveals Mechanistic Insights Driving Erythroid Development"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gene Regulation in Erythroid Development and Differentiation
Discussion Leaders: Gerd Blobel (Children's Hospital of Philadelphia, United States) and Kyle Hewitt (University of Nebraska Medical Center, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Stuart Orkin (Harvard Medical School, United States)
"Regulation of HbF Repression by BCL11A"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Scott Peslak (University of Pennsylvania, United States)
"Cellular Signaling Pathways in the Regulation of Fetal Hemoglobin for Treatment of Sickle Cell Disease"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Marlies Rossmann (University of Rochester Medical Center, United States)
"TIF1? Counteracts Ferroptosis to Drive Erythroid Progenitor Differentiation"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Mira Kassouf (University of Oxford, United Kingdom)
"New Insights into the Transcriptional Regulation of the Alpha Globin Gene in Erythropoiesis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Dagmar Zigackova (Yale University, United States)
"All-or-None pre-mRNA Processing of Globin Transcripts"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Andrew Perkins (Monash University, Australia)
"New Regulators of Human EPOR Signaling"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure