Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Hematopoietic Differentiation and Development
7:40 pm - 8:10 pm
"HbF Silencing by BCL11A"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Mechanisms of Hematopoietic Fate Specification in Megakaryocytic Erythroid Progenitors"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"Erythroid Specification Mechanisms at the Top of the Hematopoietic Hierarchy"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Regulation of Primitive and Definitive Erythropoiesis"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Intrinsic Factors: Signaling Pathways and Metabolism
9:00 am - 9:15 am
"Regulation of Red Blood Cell Differentiation through Metabolic and Epigenetic Network of S-Adenosylmethionine"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Metabolism and Signaling Pathways"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Mitochondrial Metabolic Checkpoint, Hematopoietic Stem Cell Aging and Rejuvenation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Lipoprotein Metabolism Mediates Hematopoietic Stem Cell Responses Under Acute Anemic Conditions"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Leveraging NMD to Target Gene Expression in Erythropoiesis"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Mitochondrial Supersulfides and Erythroid Development"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"The Inflammatory Cytokine IL17 Tunes and Amplifies the Erythropoietic Response to Erythropoietin In Vivo"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Extrinsic Factors: Microenvironment and Iron
7:30 pm - 7:45 pm
"Modulation of Ineffective Erythropoiesis by Monoferric Transferrins"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Erythroblastic Island Macrophages in Normal and Disordered Erythropoiesis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Spic Is a Unifying Marker for the Heterogeneous Groups of Erythromyeloblastic Island Macrophages that Support Baseline and Stress Erythropoiesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Mechanistic Role of Erythroferrone in the Crosstalk between Erythropoiesis, Iron Metabolism, and Bone Homeostasis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Heme Trafficking at the Birth and Death of Red Cells"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Mitochondria-Based Iron Monitoring System and its Role in Erythroid Survival"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Modeling Erythropoiesis and Clinical Translation
9:00 am - 9:15 am
"Luspatercept Modulates Expression Kinetics and Improves Aberrant mRNA Splicing in Sf3b1 -Mutant Erythroid Cells"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Erythropoiesis: Clinical Translation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Modeling Erythropoiesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Congenital Dyserythropoietic Anemia Type II: From Fundamental Biology to Novel Therapeutic Development"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"An Erythroid-Biased FOShi Hematopoietic Multipotent Progenitor Subpopulation Contributes to Adaptation to Chronic Hypoxia"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Hemolysis and the Immunobiology of Sickle Cell Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Red Cells from Excessive Erythropoiesis of Chronic Mountain Sickness Patients: Observations and Clinical Perspectives"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation, Infection, and Anemia
7:30 pm - 7:45 pm
"Role of Pro-Inflammatory Signals in Stress Erythropoiesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Elucidating Inflammation Mechanisms in Erythropoiesis Through Multiomics"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Mechanisms of Thrombo-Inflammation in Sickle Cell Disease"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Malaria and Erythropoiesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Science: Epigenetics and Transcription
9:00 am - 9:15 am
"LDB1 Enhancer Network Modulates Chromatin Structure in Pluripotency and Erythroid Lineage Choice"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"The Role of “Facilitators” at the Alpha-Globin Cluster and Beyond"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"LDB1 Establishes Multi-Enhancer Networks to Regulate Erythroid Gene Expression"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Reactivation of Developmentally Silenced Globin Genes through Genomic Deletions Reveals that Enhancer Distance Matters"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Regulation of Transcription"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Aberrant Properties of Anemia-Causing Variants of EKLF/KLF1"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Non-Canonical BAF Chromatin Remodeling Complex in Erythropoiesis and Globin Gene Regulation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Transcription Factor Networks Disproportionately Enrich for Heritability of Blood Cell Phenotypes"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DBA, Ribosomopathies, and Translational Regulation
7:30 pm - 7:45 pm
"A Cas9-Based Human Model System To Understand Hematopoietic Defects in Diamond-Blackfan Anemia"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Harnessing Single-Cell Technologies to Elucidate Disease Mechanisms in Diamond-Blackfan Anemia Syndrome"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Targeting Nemo-like Kinase for Treatment of Diamond Blackfan Anemia"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Translation and Erythroid Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"DBA and Ribosomopathies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cell Biology and Disorders of the Erythrocyte
9:00 am - 9:10 am
"Characterization of the Erythroid Iron Restriction Response"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Generation of Definitive Red Cells from Induced Pluripotent Stem Cells"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Production of Culture Red Blood Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"New Insights into Cellular Defects of Erythropoiesis and Hematopoiesis in Sickle Cell Disease"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:50 am
"Erythroid Islands in Mice and Humans and How They are Dysregulated in Red-Cell Diseases"
10:50 am - 10:55 am
Discussion
10:55 am - 11:05 am
"How Do Erythroblasts Enucleate?"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Regulation of Terminal Erythropoiesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Understanding the Vulnerability of Erythropoiesis during PARP Inhibitor Therapy"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Gene Therapy and DNA Damage"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genome, Proteome, and Multiome Technologies
7:30 pm - 7:45 pm
"Mass Spectrometry Based Approaches for the Study of Transcriptional Regulation During Erythropoiesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"A Novel Genome-Scale CRISPR-Cas12a Screen Identifies PTPA as a Fetal Hemoglobin Regulator via BCL11A"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Insights from Proteome Technologies"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Insights into Erythroid Biology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Understanding and Targeting Dysfunctional Metabolism in Erythropoiesis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Insights into Erythroid Biology"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure