| SATURDAY |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:40 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:40 pm - 4:30 pm | Keynote Session |
| Discussion Leaders: Luanne Peters (The Jackson Laboratory) and Mitch Weiss (CHOP) |
| 3:40 pm - 4:20 pm | Keynote Lecture: Len Zon (Harvard)
"Blood Stem Cell Self-Renewal and Differentiation - Lessons From a Fellow to a Professor"
|
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Red Cells and Erythropoiesis I |
| Discussion Leaders: Deborah Hay (Weatherall Institute of Molecular Medicine) and Jian Xu (Boston Children's Hospital) |
| 7:30 pm - 7:45 pm | Leal Oburoglu (IGMM/CNRS)
"Metabolic control of erythroid differentiation"
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| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Novalia Pishesha (Whitehead Institute for Biomedical Research)
"Transcriptional divergence and conservation of human and mouse erythropoiesis"
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| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Jie Li (New York Blood Center)
"Dynamic changes of DNA methylation and a functional role for TET2 DNA dioxygenase during human terminal erythroid differentiation"
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| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Vikram Paralkar (University of Pennsylvania)
"Long noncoding RNAs in erythropoiesis and megakaryopoiesis"
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| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Deepti Jain (The Pennsylvania State University)
"Genome wide GATA1 binding kinetics distinguish erythroid gene induction versus repression of megakaryocytic genes during differentiation"
|
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Megha Desai (Virginia Commonwealth University)
"The role of the MBD2/NuRD co-repressor complex in the developmental regulation of the fetal gamma glob in gene"
|
| 9:25 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Red Cells and Erythropoiesis II |
| Discussion Leaders: Dhvanit Shah (Brigham & Women's Hospital) and Guillaume Giraud (Erasmus) |
| 9:00 am - 9:15 am | Nan Ma (Dana-Farber Cancer Institute)
"Function of protein 4.1R in regulating Numb distribution during erythroid differentiation"
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| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Yu-Shan Huang (University of Rochester)
"Circulating primitive erythroblasts assemble a cytoskeletal network at late stages of maturation"
|
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Zhenhua Sui (SCRIPPS Research Institute)
"Tropomodulin3-null mice are embryonic lethal with anemia due to defects in definitive erythropoiesis in the fetal liver"
|
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Bart Crielaard (Weill Cornell Medical College)
"Regulation of stress erythropoiesis by macrophages is associated with the integrin beta-1/focal adhesion kinase-1 pathway"
|
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Jiahai Shi (Whitehead Institute for Biomedical Research)
"JAK2-V617F enhances red cell production by triggering CFU-E self-renewal"
|
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Huiyong Chen (New York Blood Center)
"Inhibition of Erythropoiesis by iron overload is mediated through TGFβ signaling"
|
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:45 pm | Career Development Session: Establishing a Career in Red Cell Biology |
| Discussion Leaders: Jim Palis (University of Rochester) and Len Zon (Harvard) |
| 1:30 pm - 2:10 pm | Career Development Lecture: Mitch Weiss (Children's Hospital of Philadelphia)
"Proliferation, survival and differentiation as a red cell biologist"
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| 2:10 pm - 2:20 pm | Discussion |
| 2:20 pm - 2:35 pm | Career Development Funding Opportunities: Terry Bishop (NIDDK)
"Funding opportunities from NIDDK"
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| 2:35 pm - 2:45 pm | Discussion |
| 2:45 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
