Saturday |
2:00 pm - 5:00 pm | Arrival and Check-in |
3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:45 pm - 4:30 pm | Keynote Session: From Stem Cells to Red Cells |
| Discussion Leader: Vikram Paralkar (University of Pennsylvania, USA) |
3:45 pm - 4:25 pm | Janis Abkowitz (University of Washington, USA) "The Paths from Erythroid Progenitor to Red Cell and Fellow to Professor" |
4:25 pm - 4:30 pm | Discussion |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetics, Epigenetics and Erythropoiesis |
| Discussion Leaders: Shuming Sun (New York Blood Center, USA) and Elizabeth Traxler (University of Pennsylvania, USA) |
7:30 pm - 7:45 pm | Ivan Krivega (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) "Inhibition of G9a Methyltransferase Stimulates Fetal Hemoglobin Production by Facilitating LCR/Globin Looping" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Xin Liu (University of Texas Southwestern Medical Center, USA) "Combinatorial Regulation of Enhancer Repertoires Controls Erythroid Lineage and Developmental Stage-Specific Transcription" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Maria Suciu (Weatherall Institute for Molecular Medicine, University of Oxford, United Kingdom) "Analysis at High Resolution of Transcription Factor Binding Sites at Cis Regulatory Elements During Development and Differentiation" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Yung Hwang (University of Massachusetts Medical School, USA) "Reprograming of S Phase at the Switch from Self-Renewal to Differentiation in Erythroid CFUe Progenitors Is Regulated by the Cyclin-Dependent-Kinase Inhibitor (CDKI) p57KIP2" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Raymond Liang (Icahn School of Medicine at Mount Sinai, USA) "Essential FOXO3 Functions in Polarity, Enucleation and Terminal Maturation of Red Blood Cells" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Satish Nandakumar (Boston Children's Hospital, USA) "Systematic Genetic Dissection of Common Human Variation in Red Blood Cell Traits" |
9:25 pm - 9:30 pm | Discussion |
Sunday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | Membranes and Red Cell Disorders |
| Discussion Leaders: Aishwarya Swaminathan (University of Massachusetts Medical School, USA) and Elina Ovchynnikova (Sanquin Research, The Netherlands) |
9:00 am - 9:15 am | Yang Mei (Northwestern University, USA) "Mice with Hematopoietic Specific mDia2 Deficiency Develop Ineffective Erythropoiesis Closely Mimicking Congenital Dyserythropoietic Anemia" |
9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Elizabeth Macari (Boston Children's Hospital, USA) "Calmodulin Inhibition Rescues the Effects of Ribosomal Protein Deficiency in Diamond Blackfan Anemia Models" |
9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Brian Dulmovits (Feinstein Institute for Medical Research, Hofstra North Shore-LIJ School of Medicine, USA) "Loss of RASA3 Results in Defective Terminal Erythroid Differentiation" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Satheesh Chonat (Cincinnati Children's Hospital Medical Center, USA) "The Spectrum of Alpha-Spectrin Associated Hereditary Spherocytosis" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:35 am | Novalia Pishesha (Whitehead Institute for Biomedical Research / Massachusetts Institute of Technology, USA) "Antigen-Decorated Engineered Red Blood Cells as a Novel Immune Tolerance-Inducing Agent" |
10:35 am - 10:40 am | Discussion |
10:40 am - 10:55 am | Nai-Jia Huang (Whitehead Institute, USA) "Engineering Red Cells for Anti-Botulinum Toxin" |
10:55 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Mentorship Component: Career Development |
| Discussion Leader: Bryony Graham (Weatherall Institute of Molecular Medicine, United Kingdom) |
1:30 pm - 2:05 pm | Gerd Blobel (University of Pennsylvania, USA) "Developing a Career as a Scientist" |
2:05 pm - 2:10 pm | Discussion |
2:10 pm - 2:25 pm | Terry Bishop (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) "How to Get an NIH Grant" |
2:25 pm - 2:30 pm | Discussion |
2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
3:00 pm | Seminar Concludes |