Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: About Stem Cells and Red Cells: Two Perspectives
3:45 pm - 4:05 pm
"A Developmental Journey"
4:05 pm - 4:15 pm
Discussion
4:15 pm - 4:30 pm
General Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: About Stem Cells and Red Cells: Two Perspectives (continued ) / Understanding Red Cell Formation from Different Angles
7:30 pm - 7:50 pm
"Crossing Borders of Professional, Personal and Stem Cell Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Beta-Thalassemia Beyond the Erythropoietic Defect: Impaired Self-Renewal of Hematopoietic Stem Cell Within an Altered Bone Marrow Niche"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Bmi-1 Overexpression Increases Ex Vivo Self-Renewal of Human Erythroblasts"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Analyzing the Effect of Acute Deletion of Tet2 and Tet3 Dioxygenases on Erythropoiesis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Fetal Hemoglobin Expression in Adult Erythroid Cultures Is Repressed by Signaling Activated by CD14+ Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Genome-Wide Heme and eIF2aP Regulated Gene Expression in Basophilic Erythroblasts"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Investigation at High-Resolution of Red Blood Cells Plasma Membrane Lipid Microdomains"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Transcriptional and Epigenetic Regulation of Erythropoiesis / Mentorship Component: Career Panel
The career panel consists of a diverse group of panelists, covering the spectrum of academic science at different career stages, geographic locations and type of institutions as well as alternative careers in the life sciences. Each panelist will give a brief introduction about their career path followed by a Q&A session moderated by the GRS Conference Chairs.
9:00 am - 9:10 am
"Erythropoiesis Requires Epigenetic and Transcriptional Reprogramming to Divert Hematopoietic Stem and Progenitor Cells from Pre-Primed Megakaryocytic Fate"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Signaling Centers Define Stages of Human Erythropoiesis and Harbor Common Variants of Red Blood Cell Traits"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Murine Tr4 Haploinsufficiency Results in Defective Erythropoiesis"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Career Development
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Red Cell Disorders and Therapies
1:30 pm - 1:40 pm
"Selenoproteins Play a Key Role in Stress Erythropoiesis by Regulating both the Stress Erythroid Progenitors and the Spleen Microenvironment"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
"HMGB1 Acts as a Causative Factor of Erythropoietin-Refractory Anemia Associated with Inflammation"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
"A CRISPR/Cas9 gRNA Library Screen Identifies UHRF1 as a Potential Modulator of HbF Production"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
"Differential Phosphorylation of Human Erythrocyte Proteins According to Haemoglobin S and C Carriage upon Infection by Plasmodium falciparum "
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes