Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: The Red Cell Journey: From Erythroblastic Islands to Circulation
Discussion Leaders: Martina Moras (Institut National de la Transfusion Sanguine (INTS), France) and Jens Lichtenberg (National Institutes of Health, USA)
3:45 pm - 4:05 pm
Naomi Taylor (Pediatric Oncology Branch, National Cancer Institute, NIH, USA)
"The Red Cell Formation: Erythropoiesis and Beyond"
4:05 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Patrick Gallagher (Yale University School of Medicine, USA)
"The Circulating Red Cell: In Health and Disease"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcriptional and Epigenetic Regulation of Erythropoiesis
Discussion Leaders: Robert Beagrie (University of Oxford, United Kingdom) and Mahmoud Mikdar (Institut National de la Transfusion Sanguine (INTS), France)
7:30 pm - 7:40 pm
Ryan Ashley (Feinstein Institute for Medical Research, Northwell Health, USA)
"Dexamethasone Maintains an Immature Erythroid Progenitor Population and Enhances Proliferation Through Cell Cycle Regulation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Fragka Pegka (Medical University of Innsbruck, Austria)
"Role of the Cyclin-Dependent Kinase Inhibitor p27Kip1 in Erythroid Cell Proliferation and Differentiation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Pedro Gonzalez-Menendez (Institute of Molecular Genetics of Montpellier (IGMM), France)
"Stage-Specific Changes in the Krebs Cycle Network Regulate Human Erythroid Differentiation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Elena Brindley (Feinstein Institute for Medical Research, Zucker School of Medicine at Hofstra/Northwell, USA)
"RASA3 Regulates Specific Patterns of Ras Signaling During Erythropoiesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Elisabeth Heuston (National Human Genome Research Institute, NIH, USA)
"Mouse Erythroid Commitment Occurs in Common Myeloid Progenitors"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Marlies Rossmann (Harvard University, USA)
"Tif1 Transcriptionally Regulates Mitochondrial Metabolic Pathways to Drive Erythropoiesis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Richard King (University of Michigan, USA)
"SEC23A Can Compensate for Loss of SEC23B in Murine and Human Erythroid Cells, Suggesting a Novel Treatment Paradigm for Congenital Dyserythropoietic Anemia Type II"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Julia Tischer (Cancer Research UK Cambridge Institute, University of Cambridge, United Kingdom)
"Function of Cdk5rap2 During Enucleation of Mammalian Erythroblasts"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Red Cell Diseases, Treatment and Novel Technologies for Research and Diagnostics
Discussion Leaders: Camille Roussel (Institut National de la Transfusion Sanguine (INTS), France) and Keyla Tumas (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:10 am
Pedro Moura (University of Bristol, United Kingdom)
"Investigating the Impact of Deformation and Shear Stress on Erythroid Cells"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Rajesh Gunage (Boston Children's Hospital, USA)
"Red Blood Cell Fate Is Governed by Globin m-RNA Transcriptional Stability and Translational Regulation via N6-Methyladenosine Modification"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Sophie Ramadier (Imagine Institute, France)
"Combination of Lentiviral and Genome Editing Technologies for the Treatment of Sickle Cell Disease"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Ralfs Buks (INSERM, France)
"ABCG2 Is an Importer of Ruxolitinib with Increased Expression on Red Blood Cells of MPN Patients Treated with Hydroxyurea"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sitong Zhou (Rochester Institute of Technology, USA)
"Oxygen Tension-Mediated Erythrocyte Membrane Interactions Regulate Cerebral Capillary Hyperemia"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Katie Seu (Cincinnati Children's Hospital Medical Center, USA)
"VPS4A: A Novel Candidate Gene for Congenital Dyserythropoietic Anemia"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Majed Almashjary (National Institute of Allergy and Infectious Diseases, NIH, USA)
"The Impact of Dietary Iron Restriction on Intracellular Hemoglobin Concentration and Sickling Kinetics"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Scott Peslak (University of Pennsylvania, USA)
"HRI Loss and Pharmacologic Treatments Cooperate to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development
Discussion Leader: Patrick Gallagher (Yale University School of Medicine, USA)
1:30 pm - 2:30 pm
Panel Discussion
PhD Careers, Options in Academia and Beyond
Brian Bai (National Heart, Lung, and Blood Institute, NIH, USA)
David Bodine (National Human Genome Research Institute, NIH, USA)
Corinne Duguet (Addmedica, France)
Wassim El Nemer (INSERM, France)
James Engel (University of Michigan Medical School, USA)
Jean-Antoine Ribeil (Bluebird Bio, USA)
Cindy Roy (National Institutes of Health, USA)
Naomi Taylor (Pediatric Oncology Branch, National Cancer Institute, NIH, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
