Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: The Red Cell Journey: From Erythroblastic Islands to Circulation
3:45 pm - 4:05 pm
"The Red Cell Formation: Erythropoiesis and Beyond"
4:05 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
"The Circulating Red Cell: In Health and Disease"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcriptional and Epigenetic Regulation of Erythropoiesis
7:30 pm - 7:40 pm
"Dexamethasone Maintains an Immature Erythroid Progenitor Population and Enhances Proliferation Through Cell Cycle Regulation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Role of the Cyclin-Dependent Kinase Inhibitor p27Kip1 in Erythroid Cell Proliferation and Differentiation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Stage-Specific Changes in the Krebs Cycle Network Regulate Human Erythroid Differentiation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"RASA3 Regulates Specific Patterns of Ras Signaling During Erythropoiesis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Mouse Erythroid Commitment Occurs in Common Myeloid Progenitors"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Tif1 Transcriptionally Regulates Mitochondrial Metabolic Pathways to Drive Erythropoiesis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"SEC23A Can Compensate for Loss of SEC23B in Murine and Human Erythroid Cells, Suggesting a Novel Treatment Paradigm for Congenital Dyserythropoietic Anemia Type II"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Function of Cdk5rap2 During Enucleation of Mammalian Erythroblasts"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Red Cell Diseases, Treatment and Novel Technologies for Research and Diagnostics
9:00 am - 9:10 am
"Investigating the Impact of Deformation and Shear Stress on Erythroid Cells"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Red Blood Cell Fate Is Governed by Globin m-RNA Transcriptional Stability and Translational Regulation via N6-Methyladenosine Modification"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Combination of Lentiviral and Genome Editing Technologies for the Treatment of Sickle Cell Disease"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"ABCG2 Is an Importer of Ruxolitinib with Increased Expression on Red Blood Cells of MPN Patients Treated with Hydroxyurea"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Oxygen Tension-Mediated Erythrocyte Membrane Interactions Regulate Cerebral Capillary Hyperemia"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"VPS4A: A Novel Candidate Gene for Congenital Dyserythropoietic Anemia"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"The Impact of Dietary Iron Restriction on Intracellular Hemoglobin Concentration and Sickling Kinetics"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"HRI Loss and Pharmacologic Treatments Cooperate to Strongly Elevate Fetal Hemoglobin and Reduce Sickle Cell Formation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development
1:30 pm - 2:30 pm
Panel Discussion
PhD Careers, Options in Academia and Beyond
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes