| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 5:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:00 pm | BIOINFORMATICS AND STRUCTURAL BIOLOGY |
| Discussion Leader: Todd Lowe (University of California - Santa Cruz) |
| 7:30 pm - 7:55 pm | Todd Lowe (University of California - Santa Cruz)
"A computational screen for pseudouridine-guide snoRNAs in eukaryotes and archaea" |
| 7:55 pm - 8:20 pm | Gary Stormo (Washington University - St. Louis)
"Computational methods for RNA structure and function studies" |
| 8:20 pm - 8:45 pm | Adrian Ferré-D'Amaré (Fred Hutchinson Cancer Research Center)
"Co-crystal structure of a pseudouridine synthase suggests a role as an RNA chaperone" |
| 8:45 pm - 9:00 pm | Joseph Wedekind (University of Rochester)
"Developing a model editase: using structure to predict the molecular function of APOBEC-1-related proteins (ARPs)" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:00 pm | EDITING BY NUCLEOTIDE INSERTION AND DELETION |
| Discussion Leader: Jonatha Gott (Case Western Reserve University) |
| 9:00 am - 9:25 am | Jonatha Gott (Case Western Reserve University)
"Physarum editing site determinants" |
| 9:25 am - 9:50 am | Steve Hajduk (University of Alabama - Birmingham)
"Pathway of RNA editing complex assembly in trypanosomes" |
| 9:50 am - 10:20 am | Coffee Break and Group Photo |
| 10:20 am - 10:45 am | Larry Simpson (University of California - Los Angeles)
"Isolation of a core editing complex from Leishmania tarentolae
mitochondria" |
| 10:45 am - 11:10 am | Barbara Sollner-Webb (Johns Hopkins University - Baltimore)
"Progress in understanding trypanosome RNA editing" |
| 11:10 am - 11:35 am | Ken Stuart (Seattle Biomedical Research Institute)
"Structure-function analysis of the RNA editing complex of T. brucei" |
| 11:35 am - 12:00 pm | Laurie Read (State University of New York - Buffalo)
"RBP16 and p22 as accessory factors in trypanosome RNA editing" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:10 pm | RNA MODIFICATION: GUIDED OR NOT? |
| Discussion Leader: Skip Fournier (University of Massachusetts) |
| 7:30 pm - 7:55 pm | Henri Grosjean (LEBS, CNRS, Gif-sur-Yvette, France)
"RNA modification for scientists who study RNA editing" |
| 7:55 pm - 8:20 pm | Eric Phizicky (University of Rochester)
"tRNA modification in yeast" |
| 8:20 pm - 8:45 pm | Yi-Tao Yu (University of Rochester)
"Pseudouridylation of U2 snRNA in Saccharomyces cerevisiae is catalyzed by an RNA-independent mechanism" |
| 8:45 pm - 9:10 pm | Skip Fournier (University of Massachusetts)
"Fine-tuning the eukaryotic ribosome: effects of snoRNP-mediated nucleotide modification" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:00 pm | MECHANISM, CATALYSIS AND REGULATION OF ADARS |
| Discussion Leader: Peter Beal (University of Utah) |
| 9:00 am - 9:25 am | Peter Beal (University of Utah)
"The chemical mechanism of RNA editing by adenosine deamination" |
| 9:25 am - 9:50 am | David Lazinski (Tufts University)
"ADARs and viral replication" |
| 9:50 am - 10:15 am | Andrew Macmillan (University of Alberta)
"Mechanistic investigations of A-to-I editing by ADAR2" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:10 am | Rob Reenan (University of Connecticut Health Center)
"Regulation of RNA editing in Drosophila" |
| 11:10 am - 11:35 am | Chuck Samuel (University of California - Santa Barbara)
"ADAR1: expression and function in response to pathogen infections" |
| 11:35 pm - 12:00 pm | Gordon Carmichael (University of Connecticut Health Center)
"Characterization of inosine-binding proteins" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:10 pm | C-to-U EDITING IN ANIMALS |
| Discussion Leader: Nick Davidson (Washington University - St. Louis) |
| 7:30 pm - 7:55 pm | Nick Davidson (Washington University - St. Louis)
"Apobec-1 and the regulation of post-transcriptional RNA processing:
new insights and novel functions" |
| 7:55 pm - 8:20 pm | Harold Smith (University of Rochester)
"RNA-binding proteins abound for apoB mRNA editing" |
| 8:20 pm - 8:45 pm | Reuben Harris (MRC Laboratory of Molecular Biology)
"AID: a likely DNA editing enzyme" |
| 8:45 pm - 9:10 pm | Naveenan Navaratnam (Medical Research Council - London)
"Multi-functional apolipoprotein B mRNA editing complex" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:00 pm | C-to-U EDITING IN PLANTS |
| Discussion Leader: Maureen Hanson (Cornell University) |
| 9:00 am - 9:25 am | Maureen Hanson (Cornell University)
"Cis and trans factors involved in chloroplast RNA editing" |
| 9:25 am - 9:50 am | Junichi Obokata (Nagoya University)
"Biochemical analysis of the factors required for RNA editing in
chloroplasts" |
| 9:50 am - 10:15 pm | Rainer Maier (Botanisches Institut der LMU, München)
"On the origin and evolution of RNA editing in plastids" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:10 am | Jean-Claude Farré (University of California - San Diego)
"cis-Recognition elements in plant mitochondrion RNA editing" |
| 11:10 am - 11:35 am | Axel Brennicke (Universität Ulm)
"RNA editing in plant mitochondria: cis and trans requirements" |
| 11:35 am - 12:00 pm | Jobst Greeve (University of Bern)
"Reconstitution of mRNA editing in yeast using a Gal4-Gal80 fusion
transcript" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:10 pm | GUIDED RNA MODIFICATIONS |
| Discussion Leader: Patrick Dennis (National Science Foundation) |
| 7:30 pm - 7:55 pm | Susan Baserga (Yale School of Medicine)
"New insights into eukaryotic ribosome biogenesis" |
| 7:55 pm - 8:20 pm | Patrick Dennis (National Science Foundation)
"In vitro reconstitution and activity of a C/D box methylation-guide
ribonucleoprotein complex" |
| 8:20 pm - 8:45 pm | Patrice Vitali (Universität Münster)
"Potential role of brain-specific snoRNAs in the regulation of gene expression" |
| 8:45 pm - 9:10 pm | Shulamit Michaeli (Bar-Ilan University - Israel)
"Novel properties and targets of nucleolar RNAs that guide modification in trypanosomes" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:35 am | BIOLOGICAL ROLES OF ADARS |
| Discussion Leader: Peter Seeburg (Max-Planck Institute for Medical
Research) |
| 9:00 am - 9:25 am | Peter Seeburg (Max-Planck Institute for Medical Research)
"Catastrophic events in mammalian development by ADAR deficiency" |
| 9:25 am - 9:50 am | Ron Emeson (Vanderbilt University)
"Nucleolar localization of ADAR2" |
| 9:50 am - 10:15 am | Michael Jantsch (University of Vienna)
"Role of double-stranded RNA-binding domains in nuclear entry and chromosomal targeting of ADAR1" |
| 10:15 am | Coffee Break |
| 10:45 am - 11:10 am | Liam Keegan (Medical Research Council - Edinburgh)
"Editing a fly to death" |
| 11:10 am - 11:35 am | Kazuko Nishikura (The Wistar Institute)
"Analysis of ADAR1 null mutation phenotypes" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 8:55 pm | HOT TOPICS |
| Discussion Leader: Alan Herbert (Boston University) |
| 7:30 pm - 7:55 pm | Alan Herbert (Boston University)
"ADAR1 and translation in the nucleus" |
| 7:55 pm - 8:10 pm | Joshua Rosenthal (University of California - Los Angeles)
"Squid K+ channels as a model for understanding the biological significance of adenosine deamination" |
| 8:10 pm - 8:25 pm | Daniel Kolakofsky (University of Geneva)
"Nucleocapsid protein phase and paramyxovirus RNA polymerase pseudo-templated transcription" |
| 8:25 pm - 8:40 pm | John L. Casey (Georgetown University)
"Regulation of hepatitis delta virus editing by RNA structure dynamics and hepatitis delta antigen" |
| 8:40 pm - 8:55 pm | Carla Hegeman-Crim (Cornell University)
"In vitro analysis of chloroplast editing in tobacco, pea, and Arabidopsis" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
